Results 61 to 70 of about 1,608 (173)
COSMC mutations reduce T‐synthase activity in advanced Alzheimer's disease
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020 Introduction Mutations in brain tissues that cumulate with age may contribute to Alzheimer's disease (AD). Abnormal glycoprotein and Tn antigen expression have been demonstrated in AD. We identified C1GALT1C1/COSMC mutations in AD and age‐matched normals
Seema Gollamudi +3 more
doaj +1 more source
International Journal of Oral Science, 2021 Ossifying fibroma (OF) and fibrous dysplasia (FD) are two fibro-osseous lesions with overlapping clinicopathological features, making diagnosis challenging.
Ming Ma +9 more
doaj +1 more source
Intestinal Barrier Glycosylation for Gut Physiology and Pathology
Barrier Immunity, Volume 1, Issue 1, Page 20-26, December 2025.ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley +1 more source
Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression [PDF]
Novel therapeutic strategies are urgently required for osteosarcoma, given the early age at onset and persistently high mortality rate. Modern transcriptomics techniques can identify differentially expressed genes (DEGs) that may serve as biomarkers and ...
梅田, 雄嗣 +23 more
core +2 more sources
A CRISPR Screen Using Subtilase Cytotoxin Identifies SLC39A9 as a Glycan-Regulating Factor
iScience, 2019 Summary: Subtilase cytotoxin (SubAB) is a virulence factor produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli strains.
Toshiyuki Yamaji +8 more
doaj +1 more source
Nitrate Prevents Sjögren's Disease by Modulating T Helper Cells via NF‐κB Pathway Suppression
Oral Diseases, Volume 31, Issue 12, Page 3323-3335, December 2025.ABSTRACT Objective Sjögren's disease (SjD) is a chronic autoimmune disease characterized by abnormal T helper (Th) cell distribution in the salivary glands (SGs). Although nitrate can regulate immune responses and preserve SGs function, its preventive effects on SjD remain unexplored.
Conglin Du +8 more
wiley +1 more source
, 2017 Core 1 beta 1,3-galactosyltransferase (C1GALT1) transfers galactose (Gal) to N-acetylgalactosamine (GalNAc) to form Gal beta 1,3GalNAc (T antigen). Aberrant O-glycans, such as T antigen, are commonly found in colorectal cancer.
黃敏銓;洪基翔;賴鴻緒;李伯皇;梁金銅;黃約翰 +1 more
core +1 more source
Blood group O expression in normal tissues and tumors
The FEBS Journal, Volume 292, Issue 21, Page 5697-5722, November 2025.The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. However, reliable reagents for H antigen detection are lacking. We generated two novel monoclonal antibodies using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, that specifically detect the H antigen on glycan microarrays, glycoproteins, and ...
Ea Kristine Clarisse Tulin +11 more
wiley +1 more source
Knockdown of C1GalT1 inhibits radioresistance of human esophageal cancer cells through modifying β1-integrin glycosylation [PDF]
Journal of Cancer, 2018 Radiotherapy has played a limited role for the treatment of human esophageal cancer owing to the risk of tumor radioresistance. Core 1 β1, 3-galactosyltransferase (C1GalT1), which catalyzes the formation of core 1 O-glycan structures, is frequently overexpressed during tumorigenesis.
Zhang, Chuanyi +6 more
openaire +2 more sources
The FASEB Journal, Volume 39, Issue 20, 31 October 2025.Graphical summary of glycosylation impairments in various neurodegenerative disorders. Among the diverse forms of glycosylation, the most extensively studied include N‐glycosylation, O‐glycosylation, and O‐GlcNAcylation. Aberrant glycosylation has been implicated in multiple neurodegenerative conditions.
Haihan Yu +5 more
wiley +1 more source