Results 71 to 80 of about 1,608 (173)
Advanced Science, Volume 12, Issue 38, October 13, 2025.This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao +10 more
wiley +1 more source
Targeted disruption of C1galt1 enhances nanoparticle uptake in human corneal keratinocytes.
, 2013 (A) HCLE-nt, scramble shRNA, and C1galt1 shRNA keratinocytes were incubated from the apical side with 100 nm FluoSpheres® suspensions (1010 nanoparticles/ml) for 3 h at 37°C, and subsequently examined by confocal microscopy.
Ashley M. Woodward (323985) +3 more
core +1 more source
Immunoglobulin A Nephropathy: Molecular Pathogenesis and Targeted Therapy
MedComm, Volume 6, Issue 9, September 2025.The future of IgAN treatment likely involves combining several therapies to target multiple disease mechanisms simultaneously. Clinical trials are ongoing to evaluate the efficacy and safety of various combinations. As our understanding of IgAN pathogenesis evolves, more targeted and personalized treatment strategies are expected to emerge.
Xu‐Jie Zhou
wiley +1 more source
C1galt1 abrogation does not alter tight junction integrity or function.
, 2013 (A) Whole-cell protein lysates (15 µg) were resolved on SDS-PAGE and immunoblotted with antibodies against ZO-1, occludin and GAPDH, the latter serving as loading control.
Ashley M. Woodward (323985) +3 more
core +1 more source
Advanced Science, Volume 12, Issue 26, July 10, 2025.XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue +15 more
wiley +1 more source
Caracterización biofísica y estructural de C1GalT1 en la síntesis del core 1 de los O-glicanos de tipo mucina [PDF]
, 2023 La glicosilación es una de las modificaciones post-traduccionales más comunes en proteínas y es fundamental para muchas funciones biológicas, incluyendo la regulación de la estructura y correcto funcionamiento de las proteínas, así como la interacción ...
Hurtado Guerrero, Ramón +1 more
core
ImmunobiologyBackground: Hydroxychloroquine (HCQ), by virtue of its ability to reduce proteinuria, is an alternative therapy for Immunoglobulin A nephropathy (IgAN).
Lingling Bao +4 more
doaj +1 more source
Advanced Science, Volume 12, Issue 9, March 6, 2025.Identifying tumor‐specific counter receptors for Siglecs is challenging, but can provide valuable targets for immunotherapy. Here, proximity labeling combined with genetic screening to identify DSG2 as a dominant counter receptor of Siglec‐9 in melanoma. Blocking trans interaction between DSG2 and Siglec‐9 significantly enhances macrophage phagocytosis
Ying Wu +15 more
wiley +1 more source
C1GALT1 induces HCC cell adhesion, migration and invasion through integrin β1.
, 2014 (a) The effects of the integrin β1-blocking antibody, P4C10, on C1GALT1 overexpressing cells. HCC cells were pre-treated with the indicated concentration of P4C10 or control IgG for 10 min.
I-Rue Lai (608592) +7 more
core +1 more source
C1GALT1C1‐Associated Mosaic Disorder of Glycosylation in a Female
Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.ABSTRACT Cosmc, encoded by the X‐linked C1GALT1C1, is a molecular chaperone in the endoplasmic reticulum and a master regulator of O‐glycosylation of mammalian glycoproteins. Recently, we described a germline mutation in C1GALT1C1 in two male patients, giving rise to a congenital disorder of glycosylation—COSMC‐CDG.
Rajindra P. Aryal +9 more
wiley +1 more source