Results 91 to 100 of about 1,608 (173)

MOESM4 of C1GALT1 expression is associated with galactosylation of IgA1 in peripheral B lymphocyte in immunoglobulin a nephropathy

, 2020
Additional file 4: Figure S4. Comparison of the expression of C1GALT1C1 between IgAN and Non-IgAN (A) and Healthy Control(B). (PPTX 88 kb)
Xing, Yue, Li, Lina, Zhang, Yaru, Wang, Fanghao, He, Dandan, Liu, Youxia, Jia, Junya, Yan, Tiekun, Lin, Shan   +8 more
openaire   +1 more source

Targeting tumor O‐glycosylation modulates cancer–immune‐cell crosstalk and enhances anti‐PD‐1 immunotherapy in head and neck cancer

Molecular Oncology
Cells in the tumor microenvironment (TME) communicate via membrane‐bound and secreted proteins, which are mostly glycosylated. Altered glycomes of malignant tumors influence behaviors of stromal cells.
Mei‐Chun Lin, Ya‐Ting Chuang, Hsin‐Yi Wu, Chia‐Lang Hsu, Neng‐Yu Lin, Min‐Chuan Huang, Pei‐Jen Lou   +6 more
doaj   +1 more source

Identification and validation of a glycosyltransferase gene signature as a novel prognostic model for lung adenocarcinoma

Heliyon
Background: The role of glycosyltransferase (GT) genes in lung adenocarcinoma (LUAD) needs further elucidation. Thus, our study aims to identify the prognostic gene signature of LUAD and explore its molecular functions. Methods: We initially extracted GT
Jiejun Zhou, Kun Zhang, Tian Yang, Anqi Li, Meng Li, Xiaojing Peng, Mingwei Chen   +6 more
doaj   +1 more source

C1GALT1基因多态性与维吾尔族IgA肾病易感性的关联性分析

Linchuang shenzangbing zazhi, 2014
目的 探讨β1,3-半乳糖基转移酶(C1GALT1)基因单核苷酸位点(SNP)rs9639031、rs5882115多态性与新疆维吾尔族IgA肾病(IgA nephropathy,IgAN)遗传易感性的关系。方法 选取经肾活检明确诊断为IgAN的90例维吾尔族患者为实验组,以同期在同一医院体检的90例维吾尔族健康体检者作为对照组,2组的性别和年龄等相匹配。采集纳入研究对象的外周血,提取DNA,应用PCR法扩增C1GALT1基因上2个ShIP分别为rs9639031、rs5882115位点对应的基因片段 ...
陆晨
doaj  

The genetics and epidemiology of N- and O-immunoglobulin A glycomics

Genome Medicine
Background Immunoglobulin (Ig) glycosylation modulates the immune response and plays a critical role in ageing and diseases. Studies have mainly focused on IgG glycosylation, and little is known about the genetics and epidemiology of IgA glycosylation ...
Alessia Visconti, Niccolò Rossi, Albert Bondt, Agnes Hipgrave Ederveen, Gaurav Thareja, Carolien A. M. Koeleman, Nisha Stephan, Anna Halama, Hannah J. Lomax-Browne, Matthew C. Pickering, Xu-jie Zhou, Manfred Wuhrer, Karsten Suhre, Mario Falchi   +13 more
doaj   +1 more source

Causal associations and potential mechanisms between inflammatory skin diseases and IgA nephropathy: a bi-directional Mendelian randomization study

Frontiers in Genetics
BackgroundThere is growing evidence of an association between inflammatory skin diseases and chronic kidney disease, but the association between inflammatory skin diseases and IgA nephropathy has rarely been studied.
Wenlong Cao, Jing Xiong
doaj   +1 more source

Combined Genetic Association and Differed Expression Analysis of UBE2L3 Uncovers a Genetic Regulatory Role of (Immuno)proteasome in IgA Nephropathy

Kidney Diseases
Introduction: IgA nephropathy (IgAN) is a leading cause of end-stage renal disease. The exact pathogenesis of IgAN is not well defined, but some genetic studies have led to a novel discovery that the (immuno)proteasome probably plays an important role in
Lin-Lin Xu, Ting Gan, Yang Li, Pei Chen, Su-Fang Shi, Li-Jun Liu, Ji-Cheng Lv, Hong Zhang, Xu-Jie Zhou   +8 more
doaj   +1 more source

C1GALT1 Gene [PDF]

, 2020
openaire   +1 more source

C1GALT1 wt Allele [PDF]

, 2020
openaire   +1 more source

Clathrin-mediated endocytosis is a predominant pathway for nanoparticle internalization in C1galt1 shRNA cells.

, 2013
(A) For fluorometry assays, corneal keratinocytes were pre-incubated at 37°C in the presence of inhibitors of endocytosis. After 30 min, FluoSpheres® suspensions (1010 nanoparticles/ml) were added to the cells in the continuous presence of inhibitors and
Ashley M. Woodward (323985), Jesús Pintor (103260), Ana Guzman-Aranguez (323984), Pablo Argüeso (178891)   +3 more
core   +1 more source