Results 31 to 40 of about 1,085 (173)

Cosmc converter [PDF]

The Journal of Cell Biology, 2006
Ruth Williams
core   +2 more sources

Cosmc is required for T cell persistence in the periphery [PDF]

Glycobiology, 2019
AbstractT lymphocytes, a key arm of adaptive immunity, are known to dynamically regulate O-glycosylation during T cell maturation and when responding to stimuli; however, the direct role of O-glycans in T cell maturation remains largely unknown. Using a conditional knockout of the gene (C1GalT1C1 or Cosmc) encoding the specific chaperone Cosmc, we ...
Christopher E, Cutler, Mark B, Jones, Alicia A, Cutler, Amanda, Mener, Connie M, Arthur, Sean R, Stowell, Richard D, Cummings   +6 more
openaire   +2 more sources

Cosmc overexpression enhances malignancies in human colon cancer [PDF]

Journal of Cellular and Molecular Medicine, 2019
AbstractCosmc is known as a T‐synthase‐specific molecular chaperone that plays a crucial role in the process of O‐glycosylation. Cosmc dysfunction leads to inactive T‐synthase and results in aberrant O‐glycosylation, which is associated with various tumour malignancies.
Tianbo Gao, Tan Du, Xin Hu, Xichen Dong, Lina Li, Yakun Wang, Jian Liu, Lijie Liu, Tao Gu, Tao Wen   +9 more
openaire   +2 more sources

Cosmc is an essential chaperone for correct protein O-glycosylation [PDF]

Proceedings of the National Academy of Sciences, 2010
Cosmc is a molecular chaperone thought to be required for expression of active T-synthase, the only enzyme that galactosylates the Tn antigen (GalNAcα1-Ser/Thr-R) to form core 1 Galβ1–3GalNAcα1-Ser/Thr (T antigen) during mucin type O-glycan biosynthesis. Here we show that ablation of the X-linked Cosmc gene in mice causes embryonic
Yingchun, Wang, Tongzhong, Ju, Xiaokun, Ding, Baoyun, Xia, Wenyi, Wang, Lijun, Xia, Miao, He, Richard D, Cummings   +7 more
openaire   +2 more sources

The glycosylation defect in solute carrier SLC35A2/SLC35A3 double knockout cells is rescued by SLC35A2–SLC35A3 and SLC35A3–SLC35A2 hybrids

FEBS Letters, Volume 597, Issue 18, Page 2345-2357, September 2023., 2023
In this study, the solute carriers SLC35A2 and SLC35A2 were physically joined in the two indicated orientations with an HA tag inserted in between. The resulting hybrids localized to the Golgi apparatus of the HEK293T double knockout lacking SLC35A2 and SLC35A3 and restored glycosylation defects displayed by these cells.
Wojciech Wiertelak, Artem Pavlovskyi, Dorota Maszczak‐Seneczko, Bożena Szulc, Mariusz Olczak   +4 more
wiley   +1 more source

Differential Protein and Glycan Packaging into Extracellular Vesicles in Response to 3D Gastric Cancer Cellular Organization

Advanced Science, Volume 10, Issue 24, August 25, 2023., 2023
This study reveals differential packaging of glycans and proteins in extracellular vesicles (EVs) in response to changes in cellular architecture. Signatures identified in EVs from 3D tumor cell cultures allow to cluster subgroups of gastric cancer patients with distinct prognostic information.
Álvaro M. Martins, Tânia M. Lopes, Francisca Diniz, José Pires, Hugo Osório, Filipe Pinto, Daniela Freitas, Celso A. Reis   +7 more
wiley   +1 more source

ptARgenOM—A Flexible Vector For CRISPR/CAS9 Nonviral Delivery

Small Methods, Volume 7, Issue 7, July 20, 2023., 2023
Nonviral CRISPR‐Cas9 gene editing of intracellular proteins often relies on the amplification of single‐cell clones, which can be time‐consuming and laborious. ptARgenOM, is a flexible all‐in‐one delivery vector that allows transient selection and enrichment of knockout cells using either enhanced green fluorescent protein or puromycin.
Abdelmnim Radoua, Baptiste Pernon, Nicolas Pernet, Chloé Jean, Mohammed Elmallah, Abderrahmane Guerrache, Andrei Alexandru Constantinescu, Sofiane Hadj Hamou, Jérôme Devy, Olivier Micheau   +9 more
wiley   +1 more source

MicroRNA‑196b targets COSMC in pediatric IgA nephropathy

Molecular Medicine Reports, 2020
The aim of the present study was to investigate the effect of microRNAs (miRNAs) on the expression level of core1β3‑galactosyltransferase‑specific molecular chaperone (COSMC) in immunoglobulin A nephropathy (IgAN). miRNA expression levels were determined in pediatric patients with IgAN (IgAN group), in patients with other renal diseases (control group)
Qiang, Sun, Jingchao, Lan, Hong, Zhang, Nan, Zhou, Ying, Liang, Xiaorong, Liu   +5 more
openaire   +3 more sources

External suppression causes the low expression of the Cosmc gene in IgA nephropathy [PDF]

Nephrology Dialysis Transplantation, 2008
IgA(1) aberrant O-glycosylation is one of the main pathogeneses of IgA nephropathy (IgAN), and the core I beta3-Gal-T-specific molecular chaperone (Cosmc) mRNA expression of IgAN patients was significantly decreased. This study tried to clarify whether the down-regulation was a result of genetic disorders or external suppressions.Sixty-five IgAN ...
Wei, Qin, Xiang, Zhong, Jun Ming, Fan, Ying Juan, Zhang, Xian Rong, Liu, Xing Yi, Ma   +5 more
openaire   +2 more sources

State borders in ETRS89 coordinates – reality or fiction ?

Geoinformatics FCE CTU, 2015
Common unique ETRS89 coordinates of the state boundaries are crucial for cross-border data harmonization for international projects. In the frame of European Location Framework (ELF) project Czech Office for Surveying, Mapping and Cadastre (ČÚZK ...
Jiří Poláček
doaj   +1 more source