Results 51 to 60 of about 1,085 (173)

Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens [Retraction]

Cancer Management and Research, 2022
Xu F, Wang D, Cui J, Li J, Jiang H. Cancer Manag Res. 2020;12:1017–1027. At the authors request, the Editor and Publisher of Cancer Management and Research wish to retract the published article.
Xu F, Wang D, Cui J, Li J, Jiang H
doaj  

Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model

Journal for ImmunoTherapy of Cancer, 2023
Background Treatment of some blood cancers with T cells that express a chimeric antigen receptor (CAR) against CD19 have shown remarkable results. In contrast, CAR-T cell efficacy against solid tumors has been difficult to achieve.Methods To examine the ...
David M Kranz, Edward J Roy, Preeti Sharma, Diana Rose E Ranoa, Claire P Schane, Amber N Lewis, Edward Valdez, Venkata V V R Marada, Marlies V Hager, Will Montgomery, Steven P Wolf, Karin Schreiber, Hans Schreiber, Keith Bailey, Timothy M Fan, Paul J Hergenrother   +15 more
doaj   +1 more source

The mRNA expression levels of Cosmc.

, 2015
The mRNA expression levels of Cosmc by RT-PCR. Samples are B lymphocytes from peripheral blood of the 3 groups (IgAN patients, n = 26; other renal disease patients, n = 11; healthy children participants, n = 13). Error bars represent s.e.m. and * * * for
Qiang Sun (225630), Jianqian Zhang (688743), Nan Zhou (170721), Xiaorong Liu (239247), Ying Shen (48310)   +4 more
core   +1 more source

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

Barrier Immunity, Volume 1, Issue 1, Page 20-26, December 2025.
ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley   +1 more source

COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer [PDF]

Molecular Cancer, 2015
Human pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies in the world and despite great efforts in research types of treatment remain limited. A frequently detected alteration in PDACs is a truncated O-linked N-acetylgalactosamine (GalNAc) glycosylation with expression of the Tn antigen.
Hofmann, Bianca T., Schlüter, Laura, Lange, Philip, Mercanoglu, Baris, Ewald, Florian, Fölster, Aljonna, Picksak, Aeint-Steffen, Harder, Sönke, El Gammal, Alexander T., Grupp, Katharina, Güngör, Cenap, Drenckhan, Astrid, Schlüter, Hartmut, Wagener, Christoph, Izbicki, Jakob R., Jücker, Manfred, Bockhorn, Maximilian, Wolters-Eisfeld, Gerrit   +17 more
openaire   +2 more sources

Cosmc Disruption-Mediated Aberrant O-glycosylation Suppresses Breast Cancer Cell Growth via Impairment of CD44

Cancer Management and Research, 2020
Tan Du, 1,* Xingyuan Jia, 2,* Xichen Dong, 2 Xiaoli Ru, 3 Lina Li, 2 Yakun Wang, 2 Jian Liu, 2 Guosheng Feng, 1 Tao Wen 2 1Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China;
Du T, Jia X, Dong X, Ru X, Li L, Wang Y, Liu J, Feng G, Wen T   +8 more
doaj  

Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity

Cells, 2020
Endomucin (EMCN) is the type I transmembrane glycoprotein, mucin-like component of the endothelial cell glycocalyx. We have previously shown that EMCN is necessary for vascular endothelial growth factor (VEGF)-induced VEGF receptor 2 (VEGFR2 ...
Zhengping Hu, Issahy Cano, Kahira L. Saez-Torres, Michelle E. LeBlanc, Magali Saint-Geniez, Yin-Shan Ng, Pablo Argüeso, Patricia A. D’Amore   +7 more
doaj   +1 more source

Blood group O expression in normal tissues and tumors

The FEBS Journal, Volume 292, Issue 21, Page 5697-5722, November 2025.
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. However, reliable reagents for H antigen detection are lacking. We generated two novel monoclonal antibodies using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, that specifically detect the H antigen on glycan microarrays, glycoproteins, and ...
Ea Kristine Clarisse Tulin, Lukas Muerner, Tanya R. McKitrick, Catherine A. Tilton, Lauren E. Pepi, Tianwei Jia, Maxence Noel, Leon Y. Zheng, Sean R. Stowell, Stephan von Gunten, Jamie Heimburg‐Molinaro, Richard D. Cummings   +11 more
wiley   +1 more source

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
wiley   +1 more source

Untersuchung von cosmc-Mutationen bei Patienten mit IgA-Nephropathie [PDF]

, 2009
Altered IgA1 galactosylation is involved in the pathogenesis of IgA nephropathy (IgAN), the most common glomerulonephritis in the world. The galactosyltransferase core-1 beta3-galactosyltransferase-1 (C1GALT1) and its chaperone cosmc are specifically ...
Malycha, Friederike Carola
core