Results 61 to 70 of about 1,085 (173)

COSMC is overexpressed in proliferating hemangiomas.

, 2013
(A) Immunohistochemistry of human hemangioma tissues. Paraffin-embedded hemangiomas in proliferating (N = 13), involuting (N = 21), and involuted (N = 9) phases were immunostained with anti-COSMC antibody or biotin-conjugated peanut agglutinin (PNA ...
John Huang (281422), Chia-Hua Chen (234886), Min-Chuan Huang (281425), Jian-Jr Lee (281419), Ya-Hsin Chen (281420), Ming-Ting Chen (281424), Ji-Shiang Hung (281423), Miao-Juei Huang (281421)   +7 more
core   +1 more source

The N-terminal His-tagged soluble Cosmc were expressed in Hi-5 insect cells

, 2011
The human N-terminal HPC4 epitope-tagged soluble T-synthase was expressed by cotransfecting WT Cosmc in Hi-5 insect cells. Proteins were purified directly from the media and used in coprecipitation experiments to test physical association. Galectin-3 was
Caleb J. Stowell (52653), Tongzhong Ju (52651), Richard D. Cummings (52654), Rajindra P. Aryal (52652)   +3 more
core   +1 more source

Proximity Labeling and Genetic Screening Reveal that DSG2 is a Counter Receptor of Siglec‐9 and Suppresses Macrophage Phagocytosis

Advanced Science, Volume 12, Issue 9, March 6, 2025.
Identifying tumor‐specific counter receptors for Siglecs is challenging, but can provide valuable targets for immunotherapy. Here, proximity labeling combined with genetic screening to identify DSG2 as a dominant counter receptor of Siglec‐9 in melanoma. Blocking trans interaction between DSG2 and Siglec‐9 significantly enhances macrophage phagocytosis
Ying Wu, Yuyu You, Tingsong Jiang, Yuqi He, Qingchi Fan, Xinlei Zeng, Ting Li, Yuxing Lu, Liang Qi, Fengxia Zhou, Lingyu Sun, Danyang Wang, Yong Zou, Guigen Zhang, Yanqiu Yuan, Yang Mao   +15 more
wiley   +1 more source

A unique molecular chaperone Cosmc required for activity of the mammalian core 1 β3-galactosyltransferase [PDF]

Proceedings of the National Academy of Sciences, 2002
Human core 1 β3-galactosyltransferase (C1β3Gal-T) generates the core 1 O-glycan Galβ1-3GalNAcα1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in animal glycoproteins. We report here that C1β3Gal-T activity requires expression of a molecular chaperone designated Cosmc ( co
Tongzhong, Ju, Richard D, Cummings
openaire   +2 more sources

Altered O‐glycosylation of β1‐adrenergic receptor N‐terminal single‐nucleotide variants modulates receptor processing and functional activity

The FEBS Journal, Volume 292, Issue 5, Page 998-1018, March 2025.
The human β1‐adrenergic receptor (β1AR) carries common (S49G) and rare (R31Q, A29T) single‐nucleotide polymorphisms (SNPs) in its extracellular N‐terminal domain. These were found to alter receptor O‐glycosylation and/or proteolytic cleavage, resulting in SNP‐dependent differences in β1AR cell surface expression and function that also involved the ...
Hanna E. Tuhkanen, Ilona J. Haasiomäki, Jarkko J. Lackman, Christoffer K. Goth, S. Orvokki Mattila, Zilu Ye, Sergey Y. Vakhrushev, Johanna Magga, Risto Kerkelä, Henrik Clausen, Katrine T. Schjoldager, Ulla E. Petäjä‐Repo   +11 more
wiley   +1 more source

Interleukin-17 promotes the production of underglycosylated IgA1 in DAKIKI cells

Renal Failure, 2018
Background: Interleukin 17 (IL-17) plays an important role in the pathogenesis of autoimmune diseases and might be associated with IgA nephropathy (IgAN).
Jia-Ru Lin, Ji Wen, Hui Zhang, Li Wang, Fang-Fang Gou, Man Yang, Jun-Ming Fan   +6 more
doaj   +1 more source

Alcohol induces α2‐6sialo mucin O‐glycans that kill U937 macrophages mediated by sialic acid‐binding immunoglobulin‐like lectin 7 (Siglec 7)

FEBS Open Bio, Volume 15, Issue 1, Page 165-179, January 2025.
Alcohol acts through its metabolite acetaldehyde to inactivate giantin‐mediated Golgi targeting of glycosylation enzymes. This prevents core 2 enzyme from reaching the Golgi complexes and forces other enzymes to target GM130‐GRASP65 site normally used by core 1 enzyme, which leads to formation of α2‐6sialo mucin O‐glycans that kill U937 macrophages ...
Pi‐Wan Cheng, Vishwanath‐Reddy Hothpet, Ganapati Bhat, Kristina Bailey, Lei Li, Derrick R. Samuelson   +5 more
wiley   +1 more source

Cosmc-dependent mucin-typeO-linked glycosylation is essential for podocyte function

American Journal of Physiology-Renal Physiology, 2020
Mucin-type O-linked glycosylation, a posttranslational modification affecting the stability and biophysical characteristics of proteins, requires C1GalT1 (T synthase) and its obligate, X-linked chaperone Cosmc. Hypomorphic C1GalT1 mutations cause renal failure via not yet established mechanisms.
Brian R. Stotter, Brianna E. Talbot, Diane E. Capen, Nadine Artelt, Junwei Zeng, Yasuyuki Matsumoto, Nicole Endlich, Richard D. Cummings, Johannes S. Schlondorff   +8 more
openaire   +3 more sources

Regulation of protein O-glycosylation by the endoplasmic reticulum–localized molecular chaperone Cosmc-2

, 2011
Ld-type Cosmc. Cells for Cosmc-HA and media from cell coexpressing HPC4–sT-synthase and wild-type Cosmc were harvested. The cell extracts and media were loaded on ATP-Sepharose column for chromatography and eluted with 50 mM ATP, respectively. The washes
Caleb J. Stowell (52653), Tongzhong Ju (52651), Richard D. Cummings (52654), Rajindra P. Aryal (52652)   +3 more
core   +1 more source

The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn

Oncotarget, 2016
Tn antigen (GalNAc-α-O-Ser/Thr), a mucin-type O-linked glycan, is a well-established cell surface marker for tumors and its elevated levels have been correlated with cancer progression and prognosis. There are also reports that Tn is elevated in inflammatory tissues. However, the molecular mechanism for its elevated levels in cancer and inflammation is
Ho, Chia-Wen, Lin, Chi-Yu, Liaw, Yi-Wei, Chiang, Hsiao-Ling, Chin, Yu-Tang, Huang, Rui-Lan, Lai, Hung-Cheng, Hsu, Yaw-Wen, Kuo, Po-Jan, Chen, Chiao-En, Lin, Hung-Yun, Whang-Peng, Jacqueline, Nieh, Shin, Fu, Earl, Liu, Leroy F., Hwang, Jaulang   +15 more
openaire   +3 more sources