Results 71 to 80 of about 1,085 (173)
, 2017 Expression of T antigen (Galbeta1, 3GalNAc) is associated with enhanced metastatic potential and poor prognosis in colorectal cancer. Cosmc is a molecular chaperone required for the formation of an active T-synthase, which catalyzes the synthesis of T ...
林維洲;黃敏銓;洪基翔;李伯皇;梁金銅;黃約翰 +1 more
core +1 more source
Immunoglobulin A Antibodies: From Protection to Harmful Roles
Immunological Reviews, Volume 328, Issue 1, Page 171-191, November 2024.ABSTRACT Immunoglobulin A (IgA) is the most abundantly produced antibody in humans. IgA is a unique class of immunoglobulin due to its multiple molecular forms, and a defining difference between the two subclasses: IgA1 has a long hinge‐region that is heavily O‐glycosylated, whereas the IgA2 hinge‐region is shorter but resistant to bacterial proteases ...
Patrick J. Gleeson +4 more
wiley +1 more source
Roles of AKT and ERK signaling pathways in COSMC-enhanced cell proliferation.
, 2013 (A) COSMC overexpression enhances phosphorylation of AKT and ERK. Western blotting was performed to analyze protein expression. Representative images are presented. Relative intensity of signals was quantified by ImageQuant5.1 and shown.
John Huang (281422) +7 more
core +1 more source
Clinical glycoproteomics: methods and diseases
MedComm, Volume 5, Issue 10, October 2024.An overview of clinical glycoproteomics: methods and diseases. The primary types of glycosylations include N‐glycosylation and O‐glycosylation. Three main glycoproteomic strategies are employed, with the bottom‐up approach being the most commonly utilized.
Yujia Wang +3 more
wiley +1 more source
Down-regulation of core 1 1,3-galactosyltransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1 [PDF]
Nephrology Dialysis Transplantation, 2010 Patients with IgA nephropathy (IgAN) have an increased amount of abnormally O-glycosylated IgA1 in circulation, in glomerular deposits and produced by tissue cells in vitro. Although increased production of Th2 cytokines by peripheral blood lymphocytes and a functional abnormality of core 1 β1,3-galactosyltransferase (C1β3Gal-T) have been proposed as ...
Yamada, Koshi +7 more
openaire +2 more sources
ImmunobiologyBackground: Hydroxychloroquine (HCQ), by virtue of its ability to reduce proteinuria, is an alternative therapy for Immunoglobulin A nephropathy (IgAN).
Lingling Bao +4 more
doaj +1 more source
PLoS ONE, 2015 Aberrant glycosylation occurs in the majority of human cancers and changes in mucin-type O-glycosylation are key events that play a role in the induction of invasion and metastases.
Richard Beatson +10 more
doaj +1 more source
BMC Medical Genetics, 2009 Background The deficiency of β1,3 galactose in hinge region of IgA1 molecule played a pivotal role in pathogenesis of IgA nephropathy (IgAN). Cosmc, encoded by C1GALT1C1 gene, was indispensable to β1,3 galactosylation of IgA1.
LV Ji-Cheng +5 more
doaj +1 more source
INVESTIGATION OF COSMC GENE DNA METHYLATION PROFILE AND EXPRESSION LEVEL IN IGA
, 2021 Galactosyltransferase core-1 beta3-galactosyltransferase-1 (C1GALT1) and core 1 3-galactosyltransferase-specific molecular chaperone (COSMC) are required for the O-glycosylation of the IgA1 hinge region.
Akgul, Sebahat U. +7 more
core
Cadastral map supersession acording new instructions [PDF]
Acta Montanistica Slovaca, 2009 Digital form o cadastral map exists on 36 % of cadastral areas of the Czech republic. Contemporary rate of dogitalizationis 2-3 % of total number cadastral areas anually. In Jule 2007 was approved by goverment decree N.
Alena Berková
doaj