Results 81 to 90 of about 1,085 (173)

Monocyte-mediated shaving is not affected by COSMC KO.

, 2013
A) Histogram plots representing the fluorescent intensity of the EGF-R expression as determined by Erbitux® binding. Left panel shows Capan-1 WT and COSMC KO, right panel T47D WT and COSMC KO. Secondary Ab staining alone was used as a background control (
Caroline B. Madsen (117273), Malene B. Vester-Christensen (455477), Anders Elm Pedersen (455478), Kirstine Lavrsen (117279), Catharina Steentoft (455476), Henrik Clausen (117282), Hans H. Wandall (117287)   +6 more
core   +1 more source

Regulation of protein O-glycosylation by the endoplasmic reticulum–localized molecular chaperone Cosmc-0

, 2011
D with Cosmc-HA or with T-synthase–HPC4 and stained with rat anti-HA IgG1 (green) and rabbit anti-calnexin IgG (red; A–C; bars, 4 μm) or with mouse anti-HPC4 (green) and rabbit anti–α-ManII (red; D–F; bars, 8 μm).
Caleb J. Stowell (52653), Tongzhong Ju (52651), Richard D. Cummings (52654), Rajindra P. Aryal (52652)   +3 more
core   +1 more source

Immature O-glycans recognized by the macrophage glycoreceptor CLEC10A (MGL) are induced by 4-hydroxy-tamoxifen, oxidative stress and DNA-damage in breast cancer cells

Cell Communication and Signaling, 2019
Background Ligands of the C-type lectin CLEC10A such as Tn and sialyl-Tn representing early intermediates of O-glycosylation are hallmarks of many human malignancies.
Anna-Katharina Kurze, Sophia Buhs, Dennis Eggert, Leticia Oliveira-Ferrer, Volkmar Müller, Axel Niendorf, Christoph Wagener, Peter Nollau   +7 more
doaj   +1 more source

COSMC KO renders Capan-1 and T47D cells more susceptible to ADCC.

, 2013
A)–C) WT and COSMC KO target cells were labeled with chromium and co-cultured with PBMC effector cells in an E/T ratio of 50∶1 (black) and 25∶1 (white) either with or without Ab (Erbitux®). After 4 hrs the chromium release into the media was measured and
Caroline B. Madsen (117273), Malene B. Vester-Christensen (455477), Anders Elm Pedersen (455478), Kirstine Lavrsen (117279), Catharina Steentoft (455476), Henrik Clausen (117282), Hans H. Wandall (117287)   +6 more
core   +1 more source

Autoantibodies Specific for Galactose-Deficient IgA1 in IgA Vasculitis With Nephritis

Kidney International Reports, 2019
Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1–specific autoantibodies in pathogenic immune complexes. Renal biopsy histopathologic features of IgA vasculitis (
Hitoshi Suzuki, Zina Moldoveanu, Bruce A. Julian, Robert J. Wyatt, Jan Novak   +4 more
doaj   +1 more source

Additional file 5: of Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers

, 2018
Summary of the expression of Tn and STn antigens and T-synthase/Cosmc in human colorectal cancer samples. A Table containing the antigen expression and changes in expression in all of the anonymous case studies.
Xiaodong Sun (166163), Tongzhong Ju (52651), Richard Cummings (1822642)   +2 more
core   +1 more source

Altered O-linked glycosylation in benign and malignant meningiomas [PDF]

PeerJ
Background Changes in protein glycosylation have been reported in various diseases, including cancer; however, the consequences of altered glycosylation in meningiomas remains undefined.
Chutima Talabnin, Thanawat Trasaktaweesakul, Pitchanun Jaturutthaweechot, Pundit Asavaritikrai, Dusit Kongnawakun, Atit Silsirivanit, Norie Araki, Krajang Talabnin   +7 more
doaj   +2 more sources

Additional file 1: of Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers

, 2018
Genetic alterations of Cosmc in cancer cell lines and specimens. A Table containing the names of the cell line used and a summary of expression and genetic details including references.
Xiaodong Sun (166163), Tongzhong Ju (52651), Richard Cummings (1822642)   +2 more
core   +1 more source

Glaucumolides C-P, cembrane-type diterpenoids from the marine soft coral Sarcophyton glaucum with potential attenuating activities against IgAN nephropathy

European Journal of Medicinal Chemistry Reports
Cembranoids represent a class of diterpenes, featuring a cyclotetradecadiene backbone substituted by an isopropyl residue and three methyl groups with diverse subtypes and a panel of bioactivities.
Kang Zhou, Jian Huang, Hongli Jia, Pianpian Wang, Bin Wang, Wei Cheng, Wenhan Lin   +6 more
doaj   +1 more source

Global Loss of Core 1-Derived O-Glycans in Mice Leads to High Mortality Due to Acute Kidney Failure and Gastric Ulcers

, 2022
The core 1 structure is the major constituent of mucin-type O-glycans, which are added via glycosylation—a posttranslational modification present on membrane-bound and secretory proteins.
Takashi Sato, Takashi Kudo, Riku Suzuki, Rikako Koiwai, Sayaka Fuseya, Yuki Nakamura, Yuka Murakami, Kozue Hagiwara, Satoru Takahashi   +8 more
core   +1 more source