Results 101 to 110 of about 1,085 (173)
Schematic representation of the early stages of mucin-type O-linked glycosylation.
, 2015 After the addition of the first sugar (GalNAc) to serine or threonine the core 1 or T antigen is synthesized by the action of T synthase which requires the activity of COSMC for its action. Core1 can be further extended.
Ulla Mandel (736190) +10 more
core +1 more source
, 2018 Eine Vielzahl von Pankreaskarzinomen zeigen eine Expression von Tn-Antigen. Dies beruht auf einer Ausschaltung von Cosmc und einer folgenden Inaktivität der T-Synthase.
Wolpers, Thomas
core
WITHDRAWN: The Cosmc connection to the Tn antigen in cancer.
Disease markersAhead of Print article withdrawn by publisher. At request of the authors, this article will be published in the journal Cancer Biomarkers (ISSN 1574-0153).
Tongzhong, Ju +4 more
openaire +1 more source
, 2008 In IgA nephropathy pathogenic IgA1 is likely derived from bone marrow cells and exhibits reduced O-galactosylation. Defective O-galactosylation may arise from compromised expression or function of the enzyme β-galactosyltransferase and/or its molecular ...
Katharine S. Buck (7583804) +5 more
core +3 more sources
IGA nefropatisinde cosmc geni DNA metilasyon profili ve ekspresyon düzeyinin araştırılması
, 2020 IgA nefropati (IgAN), son dönem böbrek yetmezliğine (SDBY) yol açan en yaygın glomerüler hastalıklardan biridir. COSMC, C1GALT1 enzimi ile birlikte IgA1'in glikolizasyonunda rol oynayan moleküler bir şaperondur. IgAN hastalarında GdIgA1 seviyesi artarken, COSMC mRNA seviyesinin düştüğü gösterilmiştir, fakat bu mekanizma henüz açıklanmamıştır.
openaire +2 more sources
, 2010 Rationale : Major coronary vessels derive from the proepicardium, the cellular progenitor of the epicardium, coronary endothelium, and coronary smooth ...
Mariliza V. Rodrigues +9 more
core +1 more source
Zhongguo shiyan zhenduanxue目的 探索肿瘤相关糖类抗原Tn在子宫内膜癌病人中的表达及其生物学意义。方法 首先采用免疫组化染色(IHC)技术检测人子宫内膜癌组织、子宫内膜非典型增生组织和正常子宫内膜组织的Tn抗原表达状况；然后采用CRISPR/Cas9技术特异性敲除人子宫内膜癌细胞(Ishikawa、HEC-1B)的Cosmc基因以诱导Tn抗原表达；应用流式细胞技术检测Tn抗原的表达，并采用Transwell实验检测Tn抗原异常表达对子宫内膜癌细胞迁移和侵袭能力的影响；最后采用western ...
茹晓莉, 曹广明, 刘崇东
doaj
Hydroxychloroquine (HCQ) has emerged as a potential and secure antiproteinuric agent in IgA nephropathy (IgAN). This study endeavored to explore the impact of HCQ on the immune functionality and intestinal flora disorders in IgAN rats, as well as to ...
Shengfen Lin (17761909) +3 more
core +1 more source
C1GALT1-specific chaperone 1 promotes malignant phenotypes of colon cancer cells
, 2010 在合成O-glycan 結構的過程中，Galβ1,3GalNAc稱為T antigen 或Core 1 structure，是一個根部的醣類結構，此結構在正常的表皮組織中會被其他糖類轉換酵素延伸為更長的醣類結構；而在許多的癌症中卻表現著大量的T antigen結構，而此結構被證明可以增加癌細胞轉移到肝臟的機率。C1GalT1是core 1 synthase會將UDP-Gal接到GalNAc-Ser/Thr的結構上形成T antigen；而C1GALT1-specific chaperone 1 ...
林能裕, Lin, Neng-Yu
core