Results 41 to 50 of about 1,085 (173)

Si-Wu Water Extracts Protect against Colonic Mucus Barrier Damage by Regulating Muc2 Mucin Expression in Mice Fed a High-Fat Diet

Foods, 2022
A high-fat diet (HFD) could cause gut barrier damage. The herbs in si-wu (SW) include dang gui (Angelica sinensis (Oliv.) Diels), shu di huang (the processed root of Rehmannia glutinosa Libosch.), chuan xiong (rhizome of Ligusticum chuanxiong Hort.), and
Zheng Ruan, Yujuan Yu, Peiheng Han, Li Zhang, Zhongyi Hu   +4 more
doaj   +1 more source

siRNA knock-down of C1GALT1, COSMC and COSMC+C1GALT1 in IgA1-secreting cell lines increases Gd-IgA1 production.

, 2017
(a) knock-down in IgA1-secreting cell lines from healthy controls; mock-control (n = 5), non-targeting siRNA (n = 7), C1GALT1 siRNA (n = 5), COSMC siRNA (n = 7), and COSMC+C1GALT1 siRNA (n = 2); (b) knock-down in IgA1-secreting cell lines from IgAN ...
Ali G. Gharavi (156930), Jürgen Floege (13260), Nicolas Maillard (3740647), Hong Zhang (25820), Clara Fischman (3740644), Krzysztof Kiryluk (156863), Samantha Shapiro (3740638), Frank Eitner (156867), Jan Novak (156878), Zina Moldoveanu (488060), Francesco Scolari (13256), Drew Bradbury (3740635), Sindhuri Prakash (3740641), Nikol Mladkova (3740650), Yifu Li (156864), Iuliana Ionita-Laza (46441), Thomas Rauen (2671864), Bruce A. Julian (156876), Nan Chen (142925), Jingyuan Xie (156916), Francois Berthoux (156926), Robert A. LeDesma (3740632), Hitoshi Suzuki (16714), Robert J. Wyatt (156879), Ping Hou (17213), Colin Reily (3740629)   +25 more
core   +1 more source

Hypoxia induced the differentiation of Tbx18-positive epicardial cells to CoSMCs

Scientific Reports, 2016
AbstractUnderstanding the origin and differentiation mechanism of coronary vascular smooth muscle cells (CoSMCs) is very important to cardiovascular biology. The early cardiovascular system is formed in a hypoxic microenvironment and Tbx18-positive epicardial cells are a source of CoSMCs.
Xiaodong Jing, Yulin Gao, Songlin Xiao, Qin Qin, Xiaoming Wei, Yuling Yan, Ling Wu, Songbai Deng, Jianlin Du, Yajie Liu, Qiang She   +10 more
openaire   +2 more sources

Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice

Experimental and Molecular Medicine, 2018
Pancreatic disorders: when protein modification misfires Reduced levels of a protein called Cosmc in the pancreas may lead to pancreatic disorders and a rare form of diabetes.
Gerrit Wolters-Eisfeld, Baris Mercanoglu, Bianca T. Hofmann, Thomas Wolpers, Claudia Schnabel, Sönke Harder, Pascal Steffen, Kai Bachmann, Babett Steglich, Jörg Schrader, Nicola Gagliani, Hartmut Schlüter, Cenap Güngör, Jakob R. Izbicki, Christoph Wagener, Maximilian Bockhorn   +15 more
doaj   +1 more source

COSMC modulates protein degradation of VEGFR2.

, 2013
(A) COSMC overexpression delays degradation of VEGFR2. HUVECs were treated with cycloheximide (10 µg/ml) to block protein synthesis and 20 ng/ml of VEGF to trigger internalization and degradation of VEGFR2 for indicated time points.
John Huang (281422), Chia-Hua Chen (234886), Min-Chuan Huang (281425), Jian-Jr Lee (281419), Ya-Hsin Chen (281420), Ming-Ting Chen (281424), Ji-Shiang Hung (281423), Miao-Juei Huang (281421)   +7 more
core   +1 more source

Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens

Cancer Management and Research, 2020
Feng Xu,1,* Dong Wang,2,* JianXiu Cui,1 Jie Li,1 Hongchuan Jiang1 1Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China; 2Department of Oncology, Affiliated Hospital of ...
Xu F, Wang D, Cui J, Li J, Jiang H
doaj  

COSMC overexpression enhances cell growth in HUVECs.

, 2013
(A) Cell growth of HUVECs transfected with pcDNA3.1 control plasmid (open bars) or COSMC/pcDNA3.1 (closed bars) analyzed by trypan blue exclusion assays.
John Huang (281422), Chia-Hua Chen (234886), Min-Chuan Huang (281425), Jian-Jr Lee (281419), Ya-Hsin Chen (281420), Ming-Ting Chen (281424), Ji-Shiang Hung (281423), Miao-Juei Huang (281421)   +7 more
core   +1 more source

Regulation of protein O-glycosylation by the endoplasmic reticulum–localized molecular chaperone Cosmc [PDF]

The Journal of Cell Biology, 2008
Regulatory pathways for protein glycosylation are poorly understood, but expression of branchpoint enzymes is critical. A key branchpoint enzyme is the T-synthase, which directs synthesis of the common core 1 O-glycan structure (T-antigen), the precursor structure for most mucin-type O-glycans in a wide variety of glycoproteins.
Ju, Tongzhong, Aryal, Rajindra P., Stowell, Caleb J., Cummings, Richard D.   +3 more
openaire   +2 more sources

COSMC overexpression modulates O-glycans on VEGFR2.

, 2013
(A) Changes in O-glycans on VEGFR2 in COSMC overexpressing HUVECs. Cell lysates of HUVECs transfected with control or COSMC plasmids were treated with or without neuraminidase, pulled down with VVA or PNA lectins, then immunoblotted with anti-VEGFR2 ...
John Huang (281422), Chia-Hua Chen (234886), Min-Chuan Huang (281425), Jian-Jr Lee (281419), Ya-Hsin Chen (281420), Ming-Ting Chen (281424), Ji-Shiang Hung (281423), Miao-Juei Huang (281421)   +7 more
core   +1 more source

Non‐Natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity

Angewandte Chemie, Volume 136, Issue 49, December 2, 2024.
A chemically defined vaccine is prepared by combining the structural design of a non‐natural glycopeptide antigen with a site‐specific protein modification. The resulting vaccine, which contains a single copy of the antigen, is both prophylactically and therapeutically effective. Importantly, this approach refutes a prevailing dogma that glycoconjugate
Ana Guerreiro, Ismael Compañón, Foivos S. Lazaris, Carlos Labão‐Almeida, Paula Oroz, Mattia Ghirardello, Marta C. Marques, Francisco Corzana, Gonçalo J. L. Bernardes   +8 more
wiley   +2 more sources