Results 21 to 30 of about 1,085 (173)

Targeting Tn Antigen Suppresses Aberrant O-Glycosylation-Elicited Metastasis in Breast Cancer. [PDF]

J Cell Mol Med
ABSTRACT The Tn antigen, a truncated O‐glycan representing aberrant mucin‐type O‐glycosylation, is frequently observed in human breast cancer. However, the functional role of Tn antigen in breast cancer metastasis remains insufficiently investigated. This study aimed to elucidate the expression profile of Tn antigen in breast cancer and its potential ...
Du T, Dong X, Tan J, Chen X, Liu J, Wen T, Ru X.   +6 more
europepmc   +2 more sources

Substrate O-glycosylation actively regulates extracellular proteolysis. [PDF]

Protein Sci
Abstract Extracellular proteolysis critically regulates cellular and tissue responses and is often dysregulated in human diseases. The crosstalk between proteolytic processing and other major post‐translational modifications (PTMs) is emerging as an important regulatory mechanism to modulate protease activity and maintain cellular and tissue ...
Madzharova E, Sabino F, Kalogeropoulos K, Francavilla C, Auf dem Keller U.   +4 more
europepmc   +2 more sources

Overexpression of Tn antigen induces chronic pancreatitis in mice [PDF]

Scientific Reports
Altered O-glycosylation is a key contributor to various pathophysiological processes. Notably, the expression of the Tn antigen is primarily attributed to dysfunction of the chaperone Cosmc, while the overexpression of polypeptide N ...
Baris Mercanoglu, Nina Schraps, Anastasios D. Giannou, Elena Neuburg, Jan Kempski, Christoph Wagener, Nathaniel Melling, Maximilian Bockhorn, Thilo Hackert, Gerrit Wolters-Eisfeld   +9 more
doaj   +2 more sources

Germline C1GALT1C1 mutation causes a multisystem chaperonopathy. [PDF]

Proc Natl Acad Sci U S A, 2023
Mutations in genes encoding molecular chaperones can lead to chaperonopathies, but none have so far been identified causing congenital disorders of glycosylation. Here we identified two maternal half-brothers with a novel chaperonopathy, causing impaired
Elbracht, Miriam, Reusch, Björn, Büttner-Herold, Maike, Aryal, Rajindra P, Altmüller, Janine, Kohl, Stefan, Wenzel, Andrea, Rouvet, Isabelle, Tschernoster, Nikolai, Seibert, Felix S, Thiele, Holger, Weber, Lutz T, Mürner, Lukas Dominic, Cummings, Sandra F, Häusler, Martin G, Habbig, Sandra, Knopp, Cordula, Rappl, Gunter, Erger, Florian, Noel, Maxence, Schröder-Braunstein, Jutta, Cummings, Richard D, Beck, Bodo B, Meyer, Robert, Matsumoto, Yasuyuki, Zeng, Junwei   +25 more
core   +4 more sources

Deciphering the Underlying Mechanisms Linking Psoriasis and IgA Nephropathy. [PDF]

J Immunol Res
Psoriasis is a chronic, immune‐mediated inflammatory disease with systemic manifestations that include renal complications. Immunoglobulin A nephropathy (IgAN) represents the most common autoimmune glomerular disease worldwide. Growing epidemiological and genetic evidence supports a clinically relevant association between psoriasis and IgAN ...
Tang Z, Wu J, Dong M, Li C, Wang R.
europepmc   +2 more sources

Transcriptome, glycome, and mucinome analysis reveal zinc is essential for the composition of mucus in the human goblet cell model HT-29-MTX [PDF]

Scientific Reports
Zinc (Zn) deficiency affects approximately 1 billion people worldwide with severe consequences for their health, including increased intestinal infections, inflammation, and diarrhea. Accordingly, the intestinal defense barrier is compromised, leading to
Christoph Schüßler, Nara Chung, Renaud Léonard, Heike Sprenger, Tari Rödel, Keira E. Mahoney, Susanne Thomsen, Esther Ocket, Claudia Matthaeus, Jordan Denis, Franziska Ebert, Marvin Wolf, Willy Morelle, François Foulquier, Albert Braeuning, Catherine Robbe Masselot, Stacy A. Malaker, Maria Maares   +17 more
doaj   +2 more sources

Tumor-associated Tn and STn antigens: from molecular mechanism to precision diagnosis and treatment [PDF]

Frontiers in Immunology
BackgroundAbnormal protein glycosylation is a key feature of tumors. Among the modifications, Tn antigen (GalNAcα1-Ser/Thr) and its sialylated derivative, STn antigen (Neu5Acα2-6GalNAcα1-O-Ser/Thr), are prominent tumor-associated carbohydrate antigens ...
Shuailong Zhao, Cegang Fu, Boya Gong, Hongyan Wu, Ruitao Zhang, Huili Cai, Haidan Chen, Haidan Chen   +7 more
doaj   +2 more sources

Dioscin attenuates Gd-IgA1 overproduction by inhibiting the IL-6-JAK2/STAT3 signaling axis in IgA nephropathy [PDF]

BMC Nephrology
Background Inflammation is a key driver in IgA nephropathy (IgAN) pathogenesis. Recent studies have demonstrated a significant association between pro-inflammatory cytokine–triggered inflammatory cascades, particularly those involving interleukin-6 (IL-6)
Lan Lin, HuiMei Li, ShiQiang Zhou, LiHua Zheng, ShiPeng Sun, Shen Li   +5 more
doaj   +2 more sources

O-GlcNAcylation determines the function of the key O-GalNAc glycosyltransferase C1GalT1 in bladder cancer [PDF]

Acta Biochimica et Biophysica Sinica
Protein glycosylation is a type of protein post-translational modification. One specific example is the modification of proteins with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc).
Jiang Yazhuo, Wu Jinpeng, Guan Feng, Liang Liang, Wang Yili   +4 more
doaj   +2 more sources

Unraveling the role of C1GALT1 in abnormal glycosylation and colorectal cancer progression [PDF]

Frontiers in Oncology
C1GALT1 plays a pivotal role in colorectal cancer (CRC) development and progression through its involvement in various molecular mechanisms. This enzyme is central to the O-glycosylation process, producing tumor-associated carbohydrate antigens (TACA ...
Hong Tian, Jia-Li Yu, Xiaoli Chu, Qi Guan, Juan Liu, Ying Liu   +5 more
doaj   +2 more sources