Results 1 to 10 of about 181 (69)

Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice

Frontiers in Immunology, 2021
Food allergy is an emerging epidemic, and the underlying mechanisms are not well defined partly due to the lack of robust adjuvant free experimental models of dietary antigen sensitization.
Taeko K. Noah, Taeko K. Noah, Jee-Boong Lee, Christopher A. Brown, Amnah Yamani, Amnah Yamani, Sunil Tomar, Sunil Tomar, Varsha Ganesan, Varsha Ganesan, Rodney D. Newberry, Gary B. Huffnagle, Gary B. Huffnagle, Senad Divanovic, Senad Divanovic, Senad Divanovic, Simon P. Hogan, Simon P. Hogan   +17 more
doaj   +1 more source

Immunohistochemical analysis of Tn antigen expression in colorectal adenocarcinoma and precursor lesions

BMC Cancer, 2022
Background The Tn antigen (CD175) is an O-glycan expressed in various types of human adenocarcinomas, including colorectal cancer (CRC), though prior studies have relied heavily upon poorly characterized in-house generated antibodies and lectins. In this
Gabrielle E. Dombek, Ana Sofia Ore, Jane Cheng, Yasuyuki Matsumoto, Jonathan N. Glickman, Aaron Fleishman, Jamie Heimburg-Molinaro, Vitaliy Y. Poylin, Anne Fabrizio, Thomas Cataldo, Evangelos Messaris, Richard D. Cummings   +11 more
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Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment

Biomedicines, 2022
Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosylated MUC1, also
Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Martha Minjárez-Sáenz, Javier Macías-León, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel   +11 more
doaj   +1 more source

Primary breast cancer tumours contain high amounts of IgA1 immunoglobulin: an immunohistochemical analysis of a possible carrier of the tumour-associated Tn antigen. [PDF]

PLoS ONE, 2013
The Tn antigen (GalNAc alpha-O-Ser/Thr) as defined by the binding of the lectin, helix pomatia agglutinin (HPA) or anti-Tn monoclonal antibodies, is known to be exposed in a majority of cancers, and it has also been shown to correlate positively with the
Charlotte Welinder, Bo Baldetorp, Ola Blixt, Dorthe Grabau, Bo Jansson   +4 more
doaj   +1 more source

Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer

Frontiers in Oncology, 2020
Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been correlated to poor prognosis and metastasis in multiple cancer types. However, the exact mechanisms exerted by Tn antigen to support tumor growth are still lacking.
Lenneke A. M. Cornelissen, Athanasios Blanas, Anouk Zaal, Joost C. van der Horst, Laura J. W. Kruijssen, Tom O’Toole, Yvette van Kooyk, Sandra J. van Vliet   +7 more
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The (Sialyl) Tn antigen: Contributions to immunosuppression in gastrointestinal cancers

Frontiers in Oncology, 2023
Cellular signaling pathways are intricately regulated to maintain homeostasis. During cancer progression, these mechanisms are manipulated to become harmful. O-glycosylation, a crucial post-translational modification, is one such pathway that can lead to
Christabelle Rajesh, Prakash Radhakrishnan   +1 more
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Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine

European Journal of Histochemistry, 2009
Tn, sialosyl-Tn and T antigens are simple mucintype carbohydrate antigens that may be expressed in human neoplasies due to alteration of the glycoprotein biosynthetic pathway.
M Grosso, E Vitarelli, G Giuffrè, G Tuccari, G Barresi   +4 more
doaj   +3 more sources

Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn+ colorectal cancer cells from modifying their O-glycosylation status

Stem Cell Research & Therapy, 2023
Background Cosmc (C1GalT1C1) mutation could cause aberrant O-glycosylation and result in expression of Tn antigen on the surface of tumor cells (Tn+ cells), which is associated with the metastasis and prognosis of cancer progression.
Wen Hu, Ruisong Ding, Mengyang Wang, Panpan Huang, Xia Wei, Xingyou Hu, Tao Hu   +6 more
doaj   +1 more source

Challenges in Antibody Development against Tn and Sialyl-Tn Antigens

Biomolecules, 2015
The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive ...
Liliana R. Loureiro, Mylène A. Carrascal, Ana Barbas, José S. Ramalho, Carlos Novo, Philippe Delannoy, Paula A. Videira   +6 more
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An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8+ T cells

Frontiers in Immunology, 2023
Dendritic cell (DC)-maturation stimuli determine the potency of these antigen-presenting cells and, therefore, the quality of the T-cell response. Here we describe that the maturation of DCs via TriMix mRNA, encoding CD40 ligand, a constitutively active ...
Wout de Mey, Hanne Locy, Kirsten De Ridder, Phaedra De Schrijver, Dorien Autaers, Asma Lakdimi, Arthur Esprit, Lorenzo Franceschini, Kris Thielemans, Magali Verdonck, Karine Breckpot   +10 more
doaj   +1 more source