Results 31 to 40 of about 621,434 (269)

Using Synthetic Glycans to Investigate Anti-Glycan Antibodies and Explore Their Medical Potential. [PDF]

Angew Chem Int Ed Engl
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Weber F, Valenti A, Ledvinka J, Moscovitz O, Seeberger PH.   +4 more
europepmc   +2 more sources

Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens [Retraction]

Cancer Management and Research, 2022
Xu F, Wang D, Cui J, Li J, Jiang H. Cancer Manag Res. 2020;12:1017–1027. At the authors request, the Editor and Publisher of Cancer Management and Research wish to retract the published article.
Xu F, Wang D, Cui J, Li J, Jiang H
doaj  

Shigella flexneri targets human colonic goblet cells by O antigen binding to Sialyl-Tn and Tn antigens via glycan-glycan interactions

, 2020
Shigella flexneri targets colonic cells in humans to initiate invasive infection processes that lead to dysentery, and direct interactions between their lipopolysaccharide O antigens and blood group A related glycans are involved in the cell adherence ...
Tran, ENH, Poole, J., Tran, E.N.H., Tse, E., Jennings, M.P., Morona, R, Poole, J, Tse, E, Day, C.J., McCartney, E., Day, CJ, Jennings, MP, McCartney, E, Morona, R.   +13 more
core   +1 more source

Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model

Journal for ImmunoTherapy of Cancer, 2023
Background Treatment of some blood cancers with T cells that express a chimeric antigen receptor (CAR) against CD19 have shown remarkable results. In contrast, CAR-T cell efficacy against solid tumors has been difficult to achieve.Methods To examine the ...
David M Kranz, Edward J Roy, Preeti Sharma, Diana Rose E Ranoa, Claire P Schane, Amber N Lewis, Edward Valdez, Venkata V V R Marada, Marlies V Hager, Will Montgomery, Steven P Wolf, Karin Schreiber, Hans Schreiber, Keith Bailey, Timothy M Fan, Paul J Hergenrother   +15 more
doaj   +1 more source

Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions

Frontiers in Chemistry, 2022
The chemoenzymatic synthesis of a series of dual N- and C-terminal–functionalized cholera toxin B subunit (CTB) glycoconjugates is described. Mucin 1 peptides bearing different levels of Tn antigen glycosylation [MUC1(Tn)] were prepared via solid-phase ...
Jonathan P. Dolan, Darren C. Machin, Simone Dedola, Robert A. Field, Robert A. Field, Michael E. Webb, W. Bruce Turnbull   +6 more
doaj   +1 more source

Retinal S-antigen Th1 cell epitope mapping in patients with Behcet's disease [PDF]

, 2009
Background - Retinal S-antigen (S-Ag) is a most characterized autoantigen of autoimmune uveitis. The recognized immunodominant epitope of human S-Ag in patients with uveitis has not been identified. In this study, we selected certain patients with active
Yang, P.Z., Du, L.P., Zhao, C.L., Lin, X.M., He, H., Zhou, H.Y., Kijlstra, A.   +6 more
core   +1 more source

Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives [PDF]

Chemical Communications, 2011
An N-terminal and C-terminal truncated recombinant α2-6-sialyltransferase cloned from Photobacterium sp. JH-ISH-224, Psp2,6ST(15-501)-His(6), was shown to be an efficient catalyst for one-pot three-enzyme synthesis of sialyl Tn (STn) antigens and derivatives containing natural and non-natural sialic acid forms.
Li, Ding, Hai, Yu, Kam, Lau, Yanhong, Li, Saddam, Muthana, Junru, Wang, Xi, Chen   +6 more
openaire   +2 more sources

The GalNAc-T Activation Pathway (GALA) is not a general mechanism for regulating mucin-type O-glycosylation.

PLoS ONE, 2017
Mucin-type O-glycosylation is initiated by the UDP-GalNAc polypeptide:N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. Their activity results in the GalNAc α1-O-Thr/Ser structure, termed the Tn antigen, which is further decorated with ...
Gaetan G Herbomel, Raul E Rojas, Duy T Tran, Monica Ajinkya, Lauren Beck, Lawrence A Tabak   +5 more
doaj   +1 more source

The crystal structure of a plant lectin in complex with the Tn antigen [PDF]

FEBS Letters, 2003
The structure of the tetrameric Vicia villosa isolectin B4 (VVLB4) in complex with a cancer antigen, the Tn glycopeptide (GalNAc‐O‐Ser), was determined at 2.7 Å resolution. The N‐acetylgalactoside moiety of the ligand binds to the primary combining site of VVLB4 in a similar way as observed for other Gal/GalNAc‐specific plant lectins.
Babino, Alvaro, Tello, Diana, Rojas, Adriana, Bay, Sylvie, Osinaga, Eduardo, Alzari, Pedro Maria   +5 more
openaire   +2 more sources

The characterisation of the peanut agglutinin an evolved plant lectin, with improved specificity to the Thompson Freidenriech antigen [PDF]

, 2013
Includes abstract.Includes bibliographical references.Peanut agglutinin (PNA), a carbohydrate binding protein, is able to recognise and bind a number of distinct carbohydrate structures that have been implicated in a number of disease pathologies in ...
Lagardien, Zaida
core   +1 more source