Results 21 to 30 of about 621,434 (269)

Amplified Detection of Breast Cancer Autoantibodies Using MUC1-Based Tn Antigen Mimics [PDF]

, 2020
In many human carcinomas, mucin-1 (MUC1) is overexpressed and aberrantly glycosylated, resulting in the exposure of previously hidden antigens. This generates new patient antibody profiles that can be used in cancer diagnosis.
Hinou, Hiroshi [0000-0003-2223-7300], Sánchez-Fernández, Elena M. [0000-0002-8617-8234], Artigas, Gerard, Ortiz Mellet, Carmen [0000-0002-7676-7721], Nishimura, Shin-Ichiro, García Fernández, José Manuel, Guillen-Poza, Pablo A., Garcia-Martin, Fayna [0000-0001-9118-3874]   +7 more
core   +1 more source

Native Tn only becomes an antigen when its protein no longer matches the protein of natural innate anti-Tn-reactive IgM

, 2023
   In view of the simultaneous formation of Helix pomatia-specific, Tn/serologically A-like glycolipids with germline-encoded anti-Helix pomatia-, Tn/A cross- reactive  IgM in the ovary of a healthy and fertile mouse, it is suggested that the mammalian ...
Peter Arend (560469)
core   +1 more source

Sialyl-tn antigen expression in Crohn's colitis [PDF]

Inflammatory Bowel Diseases, 1997
: Expression of the mucin-associated sialyl-Tn (STn) antigen is correlated with malignant progression in the colon. In patients with longstanding ulcerative colitis (UC) who never exhibited colonic dysplasia, STn was expressed in fewer than 15% of nondysplastic surveillance colonoscopic biopsies, whereas matched patients who developed colon cancer ...
A, Ta, N, Harpaz, C, Bodian, A, Roston, L, Oberman, A, Chen, S, Itzkowitz   +6 more
openaire   +2 more sources

Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]

, 1994
The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G., Berger, Eric G, Mechtler, Karl, Rusconi, Sandro, Wagner, Ernst, Birnstiel, Max L., Cotten, Matt, Clausen, Erik, Dinter, André, Thurnher, Martin, Berger, Erik G., Clausen, Henrik, Birnstiel, Max L   +12 more
core   +1 more source

Oxygen by Carbon Replacement at the Glycosidic Linkage Modulates the Sugar Conformation in Tn Antigen Mimics [PDF]

, 2018
N-Acetylgalactosamine (GalNAc) α-O-linked to l-threonine (Thr) (Tn antigen) and several mimics of this Tn antigen have been synthesized to explore the impact of the underlying amino acid in the presentation mode of the carbohydrate moiety. The structural
Alberto Avenoza (1470724), Corzana, Francisco [0000-0001-5597-8127], Matías, Cristina, Iris A. Bermejo (4677730), Gonzalo Jiménez-Osés, Jesús M. Peregrina, Jesús H. Busto (1470733), Bermejo, Iris A. [0000-0001-8864-4852], Claudio D. Navo (1470727), Pablo Tovillas, Cristina Matías (6116069), Busto, Jesús H. [0000-0003-4403-4790], Francisco Corzana (1470730), Alberto Avenoza, Francisco Corzana, Pablo Tovillas (5099498), Navo, Claudio D. [0000-0003-0161-412X], Peregrina, Jesús M. [0000-0003-3778-7065], Cristina Matías, Claudio D. Navo, Companón, Ismael, Paula Oroz (5099504), Ismael Compañón, Gonzalo Jiménez-Osés (1340502), Avenoza, Alberto [0000-0002-5465-3555], Ismael Compañón (1858135), Paula Oroz, María M. Zurbano, Jiménez-Osés, Gonzalo [0000-0003-0105-4337], Oroz, Paula [0000-0003-0854-5059], Tovillas, Pablo, Zurbano, María M. [0000-0001-6370-3537], Jesús M. Peregrina (1470736), Jesús H. Busto, María M. Zurbano (1830772), Iris A. Bermejo   +35 more
core   +1 more source

Targeting Tn-Antigen-Positive Human Tumors with a Recombinant Human Macrophage Galactose CType Lectin

, 2021
Alterations in glycosylation cause the emergence of tumor-associated carbohydrate antigens (TACAs) during tumorigenesis. Truncation of O-glycans reveals the Thomsen nouveau (Tn) antigen, an N-acetylgalactosamine (GalNAc) frequently attached to serine or ...
Maxime Henry (4376956), Corinne Vivès (2384077), Christine Ebel (129858), Amandine Hurbin (749682), Aline Le Roy, Franck Fieschi, François Bulteau (11857258), Jean-Luc Coll, Olivier Renaudet (363908), Amandine Hurbin, Michel Thépaut (1788882), Laetitia Vanwonterghem (11857261), Christine Ebel, Jean-Luc Coll (32116), Michel Thépaut, Franck Fieschi (296308), François Bulteau, Olivier Renaudet, Aline Le Roy (10099505), Maxime Henry, Laetitia Vanwonterghem, Corinne Vivès   +21 more
core   +1 more source

Expression of tumor-associated antigens in breast cancer subtypes

Breast, 2020
Objectives: Tumor-associated antigens (TAAs) are frequently overexpressed in several cancer types. The aim of this study was to investigate the expression of TAAs in breast cancer.
Giuseppe Curigliano, Vincenzo Bagnardi, Mariacristina Ghioni, Jamila Louahed, Vincent Brichard, Frederic F. Lehmann, Antonio Marra, Dario Trapani, Carmen Criscitiello, Giuseppe Viale   +9 more
doaj   +1 more source

Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease

Biomolecules, 2022
The core-1 β1-3galactosyltransferase-specific chaperone 1 (Cosmc) is a unique molecular chaperone of core-1 β1-3galactosyltransferase(C1GALT1), which typically functions inside the endoplasmic reticulum (ER).
Ting Xiang, Muchuan Qiao, Jiangbo Xie, Zheng Li, Hailong Xie   +4 more
doaj   +1 more source

Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development

Acta Pharmaceutica Sinica B, 2022
We present a new strategy for self-adjuvanting vaccine development that has different types of covalently-linked immunostimulants as the carrier molecule.
Deying Yang, Xiang Luo, Qinghai Lian, Lingqiang Gao, Chengxin Wang, Xiaoxiao Qi, Rong Zhang, Zhongqiu Liu, Guochao Liao   +8 more
doaj   +1 more source

Targeting Tn-positive tumors with an afucosylated recombinant anti-Tn IgG

Scientific Reports, 2023
The aberrant expression of the Tn antigen (CD175) on surface glycoproteins of human carcinomas is associated with tumorigenesis, metastasis, and poor survival.
Yasuyuki Matsumoto, Nan Jia, Jamie Heimburg-Molinaro, Richard D. Cummings   +3 more
doaj   +1 more source