Results 11 to 20 of about 621,434 (269)
Overexpression of Tn antigen induces chronic pancreatitis in mice [PDF]
Scientific ReportsAltered O-glycosylation is a key contributor to various pathophysiological processes. Notably, the expression of the Tn antigen is primarily attributed to dysfunction of the chaperone Cosmc, while the overexpression of polypeptide N ...
Baris Mercanoglu +9 more
doaj +4 more sources
Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer [PDF]
Int J Mol Sci, 2020 Colorectal cancer (CRC) cells often express Tn antigen, a tumor-associated truncated immature O-glycan (GalNAcα-O-Ser/Thr) that can promote tumor progression.
Hiroshi Nakano +18 more
core +2 more sources
Rational design of a Tn antigen mimic [PDF]
Chemical Communications, 2011 3 páginas, 3 figuras, 1 tabla -- PAGS nros. 5319-5321A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural
Jesús Jiménez-Barbero +21 more
core +4 more sources
The Tn Antigen—Structural Simplicity and Biological Complexity [PDF]
Angewandte Chemie International Edition, 2011 AbstractGlycoproteins in animal cells contain a variety of glycan structures that are added co‐ and/or posttranslationally to proteins. Of over 20 different types of sugar–amino acid linkages known, the two major types are N‐glycans (Asn‐linked) and O‐glycans (Ser/Thr‐linked).
Ju, Tongzhong +2 more
openaire +4 more sources
The Cosmc connection to the Tn antigen in cancer [PDF]
Cancer Biomarkers, 2014 The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (
Tongzhong, Ju +4 more
openaire +3 more sources
Effect of anticancer therapy on Tn antigen exposure on the leucocyte membranes in patients with leukemia [PDF]
Regulatory Mechanisms in Biosystems, 2014 Tn-antigen (Thomsen-nouvelle antigen) is tumor-associated carbohydrate antigen with only one GalNAc residue attached to serine or threonine of polypeptide chain.
G. S. Maslak
doaj +2 more sources
Expression of the Tn antigen in myelodysplasia, lymphoma, and leukemia
Transfusion, 1992 Expression of the normally cryptic blood group antigen Tn has occasionally been reported in hematologic disease, but the true frequency of this change is not known.
MB Pfeiffer (15885215) +3 more
core +3 more sources
Specific Identification of Glycoproteins Bearing the Tn Antigen in Human Cells [PDF]
Angewandte Chemie International Edition, 2017 AbstractGlycoproteins contain a wealth of valuable information regarding the development and disease status of cells. In cancer cells, some glycans (such as the Tn antigen) are highly up‐regulated, but this remains largely unknown for glycoproteins with a particular glycan.
Jiangnan, Zheng +2 more
openaire +3 more sources
Tn antigen suppresses lipopolysaccharide-induced dermatitis via Clec10a
Biochemical and Biophysical Research CommunicationsC-type lectin domain family 10 member A (Clec10a), also called macrophage galactose-type lectin 1 (MGL1) or CD301a, is expressed on myeloid cells, including macrophages in the skin.
Kazuko Shibuya +13 more
core +3 more sources
Efficient and Reproducible Synthesis of an Fmoc-protected Tn Antigen [PDF]
, 2021 The total synthesis of the Thomsen-nouveau (Tn) antigen, a tumour-associated O-linked mucin glycopeptide, was achieved through a concise route. The key glycosylation step proved challenging to reproduce from the literature precedents and was most ...
John F., Trant +4 more
core +1 more source