Results 11 to 20 of about 551,022 (291)

Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer [PDF]

Frontiers in Oncology, 2020
Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been correlated to poor prognosis and metastasis in multiple cancer types. However, the exact mechanisms exerted by Tn antigen to support tumor growth are still lacking.
Lenneke A. M. Cornelissen, Athanasios Blanas, Anouk Zaal, Joost C. van der Horst, Laura J. W. Kruijssen, Tom O’Toole, Yvette van Kooyk, Sandra J. van Vliet   +7 more
doaj   +3 more sources

Immunohistochemical analysis of Tn antigen expression in colorectal adenocarcinoma and precursor lesions [PDF]

BMC Cancer, 2022
Background The Tn antigen (CD175) is an O-glycan expressed in various types of human adenocarcinomas, including colorectal cancer (CRC), though prior studies have relied heavily upon poorly characterized in-house generated antibodies and lectins. In this
Gabrielle E. Dombek, Ana Sofia Ore, Jane Cheng, Yasuyuki Matsumoto, Jonathan N. Glickman, Aaron Fleishman, Jamie Heimburg-Molinaro, Vitaliy Y. Poylin, Anne Fabrizio, Thomas Cataldo, Evangelos Messaris, Richard D. Cummings   +11 more
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The (Sialyl) Tn antigen: Contributions to immunosuppression in gastrointestinal cancers [PDF]

Frontiers in Oncology, 2023
Cellular signaling pathways are intricately regulated to maintain homeostasis. During cancer progression, these mechanisms are manipulated to become harmful. O-glycosylation, a crucial post-translational modification, is one such pathway that can lead to
Christabelle Rajesh, Prakash Radhakrishnan   +1 more
doaj   +2 more sources

Challenges in Antibody Development against Tn and Sialyl-Tn Antigens [PDF]

Biomolecules, 2015
The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive ...
Liliana R. Loureiro, Mylène A. Carrascal, Ana Barbas, José S. Ramalho, Carlos Novo, Philippe Delannoy, Paula A. Videira   +6 more
doaj   +5 more sources

Overexpression of Tn antigen induces chronic pancreatitis in mice [PDF]

Scientific Reports
Altered O-glycosylation is a key contributor to various pathophysiological processes. Notably, the expression of the Tn antigen is primarily attributed to dysfunction of the chaperone Cosmc, while the overexpression of polypeptide N ...
Baris Mercanoglu, Nina Schraps, Anastasios D. Giannou, Elena Neuburg, Jan Kempski, Christoph Wagener, Nathaniel Melling, Maximilian Bockhorn, Thilo Hackert, Gerrit Wolters-Eisfeld   +9 more
doaj   +2 more sources

The Cosmc connection to the Tn antigen in cancer. [PDF]

Cancer Biomark, 2014
The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (
Ju T, Aryal RP, Kudelka MR, Wang Y, Cummings RD.   +4 more
europepmc   +4 more sources

The Tn antigen-structural simplicity and biological complexity. [PDF]

Angew Chem Int Ed Engl, 2011
AbstractGlycoproteins in animal cells contain a variety of glycan structures that are added co‐ and/or posttranslationally to proteins. Of over 20 different types of sugar–amino acid linkages known, the two major types are N‐glycans (Asn‐linked) and O‐glycans (Ser/Thr‐linked).
Ju T, Otto VI, Cummings RD.
europepmc   +5 more sources

Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing. [PDF]

PLoS ONE, 2013
Membrane bound mucins are up-regulated and aberrantly glycosylated during malignant transformation in many cancer cells. This results in a negatively charged glycoprotein coat which may protect cancer cells from immune surveillance. However, only limited
Caroline B Madsen, Kirstine Lavrsen, Catharina Steentoft, Malene B Vester-Christensen, Henrik Clausen, Hans H Wandall, Anders Elm Pedersen   +6 more
doaj   +2 more sources

Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer. [PDF]

Int J Mol Sci, 2020
Colorectal cancer (CRC) cells often express Tn antigen, a tumor-associated truncated immature O-glycan (GalNAcα-O-Ser/Thr) that can promote tumor progression.
Matsumoto T, Okayama H, Nakajima S, Saito K, Nakano H, Endo E, Kase K, Ito M, Yamauchi N, Yamada L, Kanke Y, Onozawa H, Fujita S, Sakamoto W, Saito M, Saze Z, Momma T, Mimura K, Kono K.   +18 more
europepmc   +2 more sources

Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties. [PDF]

Int J Mol Sci, 2022
Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (GalNAc)
Costa VD, Mariño KV, Rodríguez-Zraquia SA, Festari MF, Lores P, Costa M, Landeira M, Rabinovich GA, van Vliet SJ, Freire T.   +9 more
europepmc   +2 more sources