Results 21 to 30 of about 551,022 (291)

Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice

Frontiers in Immunology, 2021
Food allergy is an emerging epidemic, and the underlying mechanisms are not well defined partly due to the lack of robust adjuvant free experimental models of dietary antigen sensitization.
Taeko K. Noah, Taeko K. Noah, Jee-Boong Lee, Christopher A. Brown, Amnah Yamani, Amnah Yamani, Sunil Tomar, Sunil Tomar, Varsha Ganesan, Varsha Ganesan, Rodney D. Newberry, Gary B. Huffnagle, Gary B. Huffnagle, Senad Divanovic, Senad Divanovic, Senad Divanovic, Simon P. Hogan, Simon P. Hogan   +17 more
doaj   +1 more source

Efficient and Reproducible Synthesis of an Fmoc-protected Tn Antigen [PDF]

, 2021
The total synthesis of the Thomsen-nouveau (Tn) antigen, a tumour-associated O-linked mucin glycopeptide, was achieved through a concise route. The key glycosylation step proved challenging to reproduce from the literature precedents and was most ...
John F., Trant, Sabrina, Piazza, Fabiola A., Chapa-Villarreal, Jonathan, Chiaramonte, Michael R., Reynolds   +4 more
core   +1 more source

Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment

Biomedicines, 2022
Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosylated MUC1, also
Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Martha Minjárez-Sáenz, Javier Macías-León, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel   +11 more
doaj   +1 more source

Amplified Detection of Breast Cancer Autoantibodies Using MUC1-Based Tn Antigen Mimics [PDF]

, 2020
In many human carcinomas, mucin-1 (MUC1) is overexpressed and aberrantly glycosylated, resulting in the exposure of previously hidden antigens. This generates new patient antibody profiles that can be used in cancer diagnosis.
Hinou, Hiroshi [0000-0003-2223-7300], Sánchez-Fernández, Elena M. [0000-0002-8617-8234], Artigas, Gerard, Ortiz Mellet, Carmen [0000-0002-7676-7721], Nishimura, Shin-Ichiro, García Fernández, José Manuel, Guillen-Poza, Pablo A., Garcia-Martin, Fayna [0000-0001-9118-3874]   +7 more
core   +1 more source

Native Tn only becomes an antigen when its protein no longer matches the protein of natural innate anti-Tn-reactive IgM

, 2023
   In view of the simultaneous formation of Helix pomatia-specific, Tn/serologically A-like glycolipids with germline-encoded anti-Helix pomatia-, Tn/A cross- reactive  IgM in the ovary of a healthy and fertile mouse, it is suggested that the mammalian ...
Peter Arend (560469)
core   +1 more source

Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]

, 1994
The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G., Berger, Eric G, Mechtler, Karl, Rusconi, Sandro, Wagner, Ernst, Birnstiel, Max L., Cotten, Matt, Clausen, Erik, Dinter, André, Thurnher, Martin, Berger, Erik G., Clausen, Henrik, Birnstiel, Max L   +12 more
core   +1 more source

Oxygen by Carbon Replacement at the Glycosidic Linkage Modulates the Sugar Conformation in Tn Antigen Mimics [PDF]

, 2018
N-Acetylgalactosamine (GalNAc) α-O-linked to l-threonine (Thr) (Tn antigen) and several mimics of this Tn antigen have been synthesized to explore the impact of the underlying amino acid in the presentation mode of the carbohydrate moiety. The structural
Alberto Avenoza (1470724), Corzana, Francisco [0000-0001-5597-8127], Matías, Cristina, Iris A. Bermejo (4677730), Gonzalo Jiménez-Osés, Jesús M. Peregrina, Jesús H. Busto (1470733), Bermejo, Iris A. [0000-0001-8864-4852], Claudio D. Navo (1470727), Pablo Tovillas, Cristina Matías (6116069), Busto, Jesús H. [0000-0003-4403-4790], Francisco Corzana (1470730), Alberto Avenoza, Francisco Corzana, Pablo Tovillas (5099498), Navo, Claudio D. [0000-0003-0161-412X], Peregrina, Jesús M. [0000-0003-3778-7065], Cristina Matías, Claudio D. Navo, Companón, Ismael, Paula Oroz (5099504), Ismael Compañón, Gonzalo Jiménez-Osés (1340502), Avenoza, Alberto [0000-0002-5465-3555], Ismael Compañón (1858135), Paula Oroz, María M. Zurbano, Jiménez-Osés, Gonzalo [0000-0003-0105-4337], Oroz, Paula [0000-0003-0854-5059], Tovillas, Pablo, Zurbano, María M. [0000-0001-6370-3537], Jesús M. Peregrina (1470736), Jesús H. Busto, María M. Zurbano (1830772), Iris A. Bermejo   +35 more
core   +1 more source

Targeting Tn-Antigen-Positive Human Tumors with a Recombinant Human Macrophage Galactose CType Lectin

, 2021
Alterations in glycosylation cause the emergence of tumor-associated carbohydrate antigens (TACAs) during tumorigenesis. Truncation of O-glycans reveals the Thomsen nouveau (Tn) antigen, an N-acetylgalactosamine (GalNAc) frequently attached to serine or ...
Maxime Henry (4376956), Corinne Vivès (2384077), Christine Ebel (129858), Amandine Hurbin (749682), Aline Le Roy, Franck Fieschi, François Bulteau (11857258), Jean-Luc Coll, Olivier Renaudet (363908), Amandine Hurbin, Michel Thépaut (1788882), Laetitia Vanwonterghem (11857261), Christine Ebel, Jean-Luc Coll (32116), Michel Thépaut, Franck Fieschi (296308), François Bulteau, Olivier Renaudet, Aline Le Roy (10099505), Maxime Henry, Laetitia Vanwonterghem, Corinne Vivès   +21 more
core   +1 more source

Shigella flexneri targets human colonic goblet cells by O antigen binding to Sialyl-Tn and Tn antigens via glycan-glycan interactions

, 2020
Shigella flexneri targets colonic cells in humans to initiate invasive infection processes that lead to dysentery, and direct interactions between their lipopolysaccharide O antigens and blood group A related glycans are involved in the cell adherence ...
Tran, ENH, Poole, J., Tran, E.N.H., Tse, E., Jennings, M.P., Morona, R, Poole, J, Tse, E, Day, C.J., McCartney, E., Day, CJ, Jennings, MP, McCartney, E, Morona, R.   +13 more
core   +1 more source

Targeting Tn-positive tumors with an afucosylated recombinant anti-Tn IgG

Scientific Reports, 2023
The aberrant expression of the Tn antigen (CD175) on surface glycoproteins of human carcinomas is associated with tumorigenesis, metastasis, and poor survival.
Yasuyuki Matsumoto, Nan Jia, Jamie Heimburg-Molinaro, Richard D. Cummings   +3 more
doaj   +1 more source