Results 81 to 90 of about 621,376 (215)
Mannosylated T/Tn with Freund’s adjuvant induces cellular immunity
International Journal of Immunopathology and Pharmacology, 2018 Inducing cancer-specific cellular immune responses has become an attractive strategy in cancer treatment. In this study, we investigated the role of several adjuvants in eliciting T/Tn-specific cellular immunity and protection against T/Tn expressing ...
Hye-Youn Son +2 more
doaj +1 more source
, 2022 Exposure of a human host to SARS-CoV-2 results in activation of the host trans-membrane protease serine subtype 2 (TMPRSS2) and the ontogenetic polypeptide GalNAc transferase, forming a cross-species, mucin-type molecular O-glycan bridge, the classical
Peter Arend (560469)
core +1 more source
SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer
Advanced Science, EarlyView.Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian +8 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang +15 more
wiley +1 more source
Scientific ReportsBreast cancer (BC) is the leading cause of death by cancer in women worldwide. Triple-negative (TN) BC constitutes aggressive and highly metastatic tumors associated with shorter overall survival of patients compared to other BC subtypes. The Tn antigen,
María Florencia Festari +4 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Systemic lupus erythematosus (SLE) is characterized by type I interferon (IFN) signaling and adaptive immune dysregulation. We previously identified hypomethylation of HLA‐DRB1 and STAT1 in SLE CD8+ T cells, enabling aberrant IFN‐driven HLA‐DRB1 expression and expansion of a distinct CD8+ T cell subset. This study characterized CD8+ HLA‐DRB1+
Huizhong Long +3 more
wiley +1 more source
Tn antigens and their significance in oncology.
Acta Biochimica Polonica, 1995 Tn and sialyl-Tn carbohydrate structures, first identified in glycophorins of persons with the rare Tn syndrome, were found to be present on the surface of most cancer cells. In this article, the studies on Tn and sialyl-Tn antigens as diagnostic and prognostic tumor markers and as immunogens in vaccines for cancer immunotherapy are shortly reviewed.
openaire +3 more sources
EXoO-Tn: Tag-n-Map the Tn Antigen in the Human Proteome [PDF]
, 2019 Abstract Tn antigen (Tn), a single N-acetylgalactosamine (GalNAc) monosaccharide attached to protein Ser/Thr residues, is found on most solid tumors yet rarely detected in adult tissues, featuring it one of the most distinctive signatures of cancers.
Yang, Weiming +4 more
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BMEMat, EarlyView.Leveraging bacterial hypoxia targeting, KBTO NPs accumulate at the tumor site. Under the ultrasound irradiation, KBTO NPs produce reactive oxygen species to kill tumor cells and eliminate bacteria, preventing overgrowth and inflammation. The lysed bacteria act as antigens to trigger antitumor immunity and further enhanced by the immune checkpoint ...
Chongyang Liu +12 more
wiley +1 more source
Production of Single-Chain Variable-Fragments against Carbohydrate Antigens
Antibodies, 2014 The production of human single-chain variable-fragments (scFvs) against carbohydrate antigens by phage display technology is seemingly a logical strategy towards the development of antibody therapeutics, since carbohydrates are self-antigens. Panning and
Yoko Fujita-Yamaguchi
doaj +1 more source