Results 261 to 270 of about 565,658 (299)

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

IKK/NF-κB Inactivation by Salidroside via Targeting TNF-α for the Treatment of LPS-Induced Colitis. [PDF]

Curr Issues Mol Biol
Ouyang Q, Zhou H, Yu Z, Jiang H, Ji C, Sun Y, Zhou F, Xiang S, Hu X.   +8 more
europepmc   +1 more source

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

Exploring the Potential Value of Lactylation and Macrophage Polarization-Related Genes as Biomarkers for TNF-α Inhibitor Response in Inflammatory Bowel Disease. [PDF]

J Inflamm Res
Han L, Lin G, Lv X, Li S, Huang Z, Li Y, Chen D, Chen X, Lin J, Chen L, Lv X.   +10 more
europepmc   +1 more source

Kadar Tumor Necrosis Factor Alpha (TNF-α) serum maternal yang tinggi pada ibu hamil sebagai faktor risiko terjadinya persalinan preterm

Adytia Theopani Bineredo Damanik, Anak Agung Gede Putra Wiradnyana, Anak Agung Ngurah Jaya Kusuma, I Nyoman Hariyasa Sanjaya, Anom Suardika, I Gde Sastra Winata   +5 more
openalex   +2 more sources

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Hemopexin Suppresses Hepatocellular Carcinoma via TNF-α-Mediated Mitochondrial Apoptosis. [PDF]

Cancers (Basel)
Ren L, Man Y, Zhang X, Guo Q, She S, Yang Y, Fei R, Cong X, Chen D, Wei W, Chen H.   +10 more
europepmc   +1 more source

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Advanced Science, EarlyView.
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit   +8 more
wiley   +1 more source

ARID3A Promotes Tumor Progression by Activating TNF-α/NF-κB Signaling in Dual-Phenotype Hepatocellular Carcinoma. [PDF]

J Hepatocell Carcinoma
Li M, Yang T, Huang J, Wu X, Chen J, Li J, Shi B, Zhang J, Xiang B.   +8 more
europepmc   +1 more source

Association of Oral Contraceptives Consumption with C-Reactive Protein (CRP), Tumor Necrosis Factor-α (TNF-α) and Interleukin (IL-6) in Female in vivo Model

International Journal of Biological Chemistry
Barizoge Cletus Lemii, Iyaeneomi Ransome Daka, Christine Umanu Gabriel-Brisibe, Sarah Kelechi Enebeli, Ucheawaji Felicia Edward, Iyingiala Austin-Asomeji, Efekemo Oghenetekevwe, Nodi Conquest Chivusalem, Tamuno-Boma Odinga-Israel   +8 more
openaire   +1 more source