Results 201 to 210 of about 10,050,273 (238)

Importance of TNF-related apoptosis-inducing ligand in pathogenesis of interstitial cystitis

International Urology and Nephrology, 2009
Although interstitial cystitis is an inflammatory disease, its etiopathogenesis is not clearly understood. The objective of the present study is to investigate the distribution of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in bladder biopsy samples of patients diagnosed with interstitial cystitis and the role of TRAIL in the ...
Omer, Kutlu, Erdem, Akkaya, Ismail Turker, Koksal, Ibrahim Cumhur, Bassorgun, Mehmet Akif, Ciftcioglu, Salih, Sanlioglu, Erdal, Kukul   +6 more
openaire   +2 more sources

The two directions of TNF-related apoptosis-inducing ligand in rheumatoid arthritis

Cytokine, 2013
The TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) superfamily that has been recognized for its specific pro-apoptotic effect on cancer cells and has been therefore proposed as a treatment in cancer. Studies on animal models have shown that TRAIL could also have a beneficial effect in rheumatoid arthritis ...
Rachel, Audo, Bernard, Combe, Michael, Hahne, Jacques, Morel   +3 more
openaire   +2 more sources

Expression of TNF-related apoptosis-inducing ligand in human hepatocellular carcinoma

International Journal of Oncology, 2005
TNF-related apoptosis-inducing ligand (TRAIL), as well as Fas ligand, plays a pivotal role in lymphocyte cytotoxicity and the maintenance of immunological homeostasis in various tissues, but its physiological role in immune evasion of cancer cells remains unknown.
Katsuya, Shiraki, Takenari, Yamanaka, Hidekazu, Inoue, Tomoyuki, Kawakita, Naoyuki, Enokimura, Hiroshi, Okano, Kazushi, Sugimoto, Kazumoto, Murata, Takeshi, Nakano   +8 more
openaire   +2 more sources

Expression of TNF-related apoptosis-inducing ligand (TRAIL) in megakaryocytes and platelets

Experimental Hematology, 2004
Platelets are known to play an important role in hemostasis, thrombosis, wound healing, and inflammation. Platelet-induced modulation of inflammation and adaptive immune responses are mediated in part through tumor necrosis factor (TNF) family member ligands, including CD154, Fas ligand, and TNFalpha, that are expressed upon platelet activation.
Scott A, Crist, Bennett D, Elzey, Aaron T, Ludwig, Thomas S, Griffith, Jeffrey B, Staack, Steven R, Lentz, Timothy L, Ratliff   +6 more
openaire   +2 more sources

The effect of exercise on osteoprotegerin and TNF‐related apoptosis‐inducing ligand in obese patients

European Journal of Clinical Investigation, 2012
Eur J Clin Invest 2012; 42 (11): 1173–1179AbstractBackground  Biomarkers of cardiovascular (CV) risk are tests that predict a patient’s risk of future CV events. Recently, two proteins involved in vascular calcification; serum levels of osteoprotegerin (OPG) and tumour necrosis factor–related apoptosis‐inducing ligand (TRAIL) have emerged as ...
Colin Davenport, Donal O'Gorman
exaly   +3 more sources

Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL)

Cellular Immunology, 2002
TNF-related apoptosis-inducing ligand (TRAIL), a type II membrane protein belonging to the TNF family, induces apoptotic cell death in various types of tumor cells. However, little is known about its pathological and physiological functions in the immune system.
Nobuhiko, Kayagaki, Noriko, Yamaguchi, Masaaki, Abe, Sachiko, Hirose, Toshikazu, Shirai, Ko, Okumura, Hideo, Yagita   +6 more
openaire   +2 more sources

Neutrophil-Derived TNF-Related Apoptosis-Inducing Ligand (TRAIL)

Cancer Research, 2004
AbstractTo detect the novel genes expressed uniquely in neutrophils and elucidate their function, the gene expression pattern was compared by using cDNA microarray containing 240 cytokine genes between the neutrophils and peripheral blood mononuclear cells (PBMCs) obtained from healthy human donors.
Yuhki Koga, Akinobu Matsuzaki, Aiko Suminoe, Hiroyoshi Hattori, Toshiro Hara   +4 more
openaire   +1 more source

TNF-related apoptosis-inducing ligand is involved in neutropenia of systemic lupus erythematosus

Blood, 2004
AbstractNeutropenia is a common laboratory finding in systemic lupus erythematosus (SLE). However, the molecular mechanism of SLE neutropenia has not been fully explained. In this study, we examined whether TNF-related apoptosis-inducing ligand (TRAIL) is involved in the pathogenesis of SLE neutropenia using samples from SLE patients.
Wataru, Matsuyama, Masuki, Yamamoto, Ikkou, Higashimoto, Ken-ichi, Oonakahara, Masaki, Watanabe, Kentarou, Machida, Teizo, Yoshimura, Nobutaka, Eiraku, Masaharu, Kawabata, Mitsuhiro, Osame, Kimiyoshi, Arimura   +10 more
openaire   +2 more sources

TNF-Related Apoptosis-Inducing Ligand (TRAIL)

2004
Tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is a protein of the tumor necrosis factor (TNF) family that has excited much recent interest as a potentially novel anticancer agent. TRAIL induces apoptosis in a wide variety of human and murine cancer cells, with no apparent apoptotic activity on normal nontransformed cells ...
openaire   +1 more source

Implication of TNF-Related Apoptosis-Inducing Ligand in Inflammatory Intestinal Epithelial Lesions

Gastroenterology, 2006
Few data exist on the molecular events causing intestinal epithelial destruction during inflammatory processes, such as inflammatory bowel disease (IBD). In this work, we analyzed the potential implication of tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) in these inflammatory lesions.TRAIL and TRAIL-receptor expression were ...
Bernadette, Begue, Harald, Wajant, Jean-Christophe, Bambou, Laurent, Dubuquoy, Daniela, Siegmund, Jean-François, Beaulieu, Danielle, Canioni, Dominique, Berrebi, Nicole, Brousse, Pierre, Desreumaux, Jacques, Schmitz, Michael J, Lentze, Oliver, Goulet, Nadine, Cerf-Bensussan, Frank M, Ruemmele   +14 more
openaire   +2 more sources