Results 251 to 260 of about 1,230,752 (303)
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Science China Life Sciences, 2020
Tumor necrosis factors (TNFs) are a group of cytokines that play critical roles in regulating a diverse range of physiological processes in vertebrates. TNFs function by activating a large number of structurally related receptors, leading to TNF mediated biological processes which are evolutionarily conserved.
Yaoguo, Li, Tiaoyi, Xiao, Jun, Zou
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Tumor necrosis factors (TNFs) are a group of cytokines that play critical roles in regulating a diverse range of physiological processes in vertebrates. TNFs function by activating a large number of structurally related receptors, leading to TNF mediated biological processes which are evolutionarily conserved.
Yaoguo, Li, Tiaoyi, Xiao, Jun, Zou
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2009
Tumor necrosis factor-α (TNF) is a pleiotropic cytokine whose biological functions regulate the cellular responses of injury and repair, inflammation and immunity, and proliferation. In the liver, TNF exerts autocrine and paracrine effects that mediate a variety of pathophysiological states that involve liver injury and cell death and/or ...
Jörn M. Schattenberg, Mark J. Czaja
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Tumor necrosis factor-α (TNF) is a pleiotropic cytokine whose biological functions regulate the cellular responses of injury and repair, inflammation and immunity, and proliferation. In the liver, TNF exerts autocrine and paracrine effects that mediate a variety of pathophysiological states that involve liver injury and cell death and/or ...
Jörn M. Schattenberg, Mark J. Czaja
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Best Practice & Research Clinical Rheumatology, 2011
There are now five anti-tumour necrosis factor (TNF) drugs licenced for use in rheumatoid arthritis. This chapter examines the similarities and differences between the drugs and looks for clues with regard to their rational prescribing. The major difference is between the monoclonal antibody-based drugs and the soluble receptor etanercept.
Thalayasingam N, Isaacs JD
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There are now five anti-tumour necrosis factor (TNF) drugs licenced for use in rheumatoid arthritis. This chapter examines the similarities and differences between the drugs and looks for clues with regard to their rational prescribing. The major difference is between the monoclonal antibody-based drugs and the soluble receptor etanercept.
Thalayasingam N, Isaacs JD
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Immunology Today, 1992
In the past few years, considerable progress has been made on the identification and characterization of tumor necrosis factor (TNF) receptors. The relative roles played by the two receptor types in signaling the diverse functions of TNF are less clear.
L A, Tartaglia, D V, Goeddel
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In the past few years, considerable progress has been made on the identification and characterization of tumor necrosis factor (TNF) receptors. The relative roles played by the two receptor types in signaling the diverse functions of TNF are less clear.
L A, Tartaglia, D V, Goeddel
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2014
?????????????? ?????????? ?????????????????? ?????????????????????????????? ?????????????? ???? ???????????? ?????????????????????????? ???????????????? TNF-?? ?? ???????????????????????????? ???????????????????? ?????????????????????????? ???????????? ???? ?????????????????? ???????????????????? ?? ?????????????????????? ?????????? ????????. ??????????
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?????????????? ?????????? ?????????????????? ?????????????????????????????? ?????????????? ???? ???????????? ?????????????????????????? ???????????????? TNF-?? ?? ???????????????????????????? ???????????????????? ?????????????????????????? ???????????? ???? ?????????????????? ???????????????????? ?? ?????????????????????? ?????????? ????????. ??????????
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Gan to kagaku ryoho. Cancer & chemotherapy, 1997
TNF exerts its biological activities through two distinct receptors of TNF-R55 and TNF-R75. Recent studies have identified TNF receptor-associated molecules, and intracellular signal transduction for apoptosis induced by TNF has been elucidated. Various TNF mutants with higher affinity to TNF-R55 and lower affinity to TNF-R75 are being clarified ...
N, Yamauchi, Y, Niitsu
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TNF exerts its biological activities through two distinct receptors of TNF-R55 and TNF-R75. Recent studies have identified TNF receptor-associated molecules, and intracellular signal transduction for apoptosis induced by TNF has been elucidated. Various TNF mutants with higher affinity to TNF-R55 and lower affinity to TNF-R75 are being clarified ...
N, Yamauchi, Y, Niitsu
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Chronic TNF-α exposure impairs TCR-signaling via TNF-RII but not TNF-RI
Cellular Immunology, 2005Chronic exposure to TNF-alpha has been shown to impair T cell-activation in mice and in humans. In the present study, we investigated a possible role of TNF-RII in this long-term effect of TNF-alpha. Chronic TNF-alpha exposure led to suppression of subsequent TCR stimulation (e.g., TCR/CD28-induced proliferation, cytokine production (IFN-gamma, TNF ...
Rosa M, Aspalter +2 more
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Introduction to TNF/pathophysiology of TNF
2006The complex organization of cellular functions in the human body requires a precise interplay of activity. Cell to cell communications must be sent and received in an efficient system. When the distance over which a signal must travel is greater then an intracellular space, soluble polypeptide factors called cytokines are employed as messenger proteins
Patricia Malerich, Dirk M. Elston
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2010
Bone is subject to permanent remodeling during development and through life. This activity is essential for (a) proper shaping and growth of each bone during development; (b) maintenance of bone mass as well as structural integrity of the micro architecture of bone through adult life, and (c) tissue repair needed for healing of fracture as well as of ...
Jean-Pierre, David, Georg, Schett
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Bone is subject to permanent remodeling during development and through life. This activity is essential for (a) proper shaping and growth of each bone during development; (b) maintenance of bone mass as well as structural integrity of the micro architecture of bone through adult life, and (c) tissue repair needed for healing of fracture as well as of ...
Jean-Pierre, David, Georg, Schett
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