Results 11 to 20 of about 12,194 (224)
Binding of TNP‐ATP and TNP‐ADP to the non‐catalytic sites of Escherichia coli F1‐ATPase [PDF]
FEBS Letters, 1997 Using site‐directed‐tryptophan fluorescence, parameters for equilibrium binding of (Mg)TNP‐ATP and (Mg)TNP‐ADP to non‐catalytic sites of Escherichia coli F1‐ATPase were determined. All three non‐catalytic sites showed the same affinity for MgTNP‐ATP (K d=0.2 μM) or MgTNP‐ADP (K d=6.5 μM) whereas even at concentrations of 100 μM no binding of ...
Weber, Joachim, Senior, Alan E
openaire +3 more sources
Swiss Medical Weekly, 2018 BACKGROUND AND OBJECTIVES TNP-2092 is a novel dual-action lead compound consisting of rifamycin SV and 4H-4-oxo-quinolizine pharmacophores, with a broad spectrum of antibacterial activities.
Ben Wang +10 more
doaj +2 more sources
A trinitrophenyl(TNP)-poly-L-lysine-horseradish peroxidase conjugate for the detection of anti-TNP antibodies in vivo. [PDF]
Journal of Histochemistry & Cytochemistry, 1985 A new conjugate for the detection of anti-trinitrophenyl(TNP) antibodies was developed to study the localization pattern of specific antibody containing cells and extracellular antibody in vivo. By means of a bridging molecule, poly-L-lysine, nine TNP groups and six horseradish peroxidase (HRP) groups were joined in one conjugate.
E, Claassen, N, Van Rooijen
openaire +3 more sources
TNP and its analogs: Modulation of IP6K and CYP3A4 inhibition [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Inositol hexakisphosphate kinase (IP6K) is an important mammalian enzyme involved in various biological processes such as insulin signalling and blood clotting. Recent analyses on drug metabolism and pharmacokinetic properties on TNP (N2-(m-trifluorobenzyl), N6-(p-nitrobenzyl)purine), a pan-IP6K inhibitor, have suggested that it may inhibit cytochrome ...
Seulgi Lee +14 more
openaire +4 more sources
A review of TNP-ATP in protein binding studies: benefits and pitfalls
Biophysical Reports, 2021 We review 50 years of use of 2′,3′-O-trinitrophenyl (TNP)-ATP, a fluorescently tagged ATP analog. It has been extensively used to detect binding interactions of ATP to proteins and to measure parameters of those interactions such as the dissociation ...
Dixon J. Woodbury +2 more
doaj +1 more source
Frontiers in Pharmacology, 2016 Thienorphine (TNP) is a novel partial opioid agonist that has completed phase II clinical evaluation as a promising drug candidate for the treatment of opioid dependence.
Ling-Lei Kong +9 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2012 Thienorphine (TNP) is a new partial opioid agonist currently developed as a promising drug candidate with the intended clinical indication for the treatment of opioid dependence.
Jingting Deng +4 more
doaj +1 more source
F1000Research, 2022 Background: Numerous smoke-free tobacco or nicotine-containing product (TNP) alternatives have been introduced to support individual- and population-level harm reduction relative to continued cigarette smoking.
Steve Roulet +8 more
doaj +1 more source
Chemical Engineering Journal Advances, 2021 Visual and selective detection of 2,4,6-trinitrophenol (TNP) for public and environmental protection is an extremely urgent issue and challenge. Herein, a novel fluorescence polyurethane (FPU) has been successfully synthesized and exploited for selective
GAO Shan +7 more
doaj +1 more source
Investigating the effect of Nigella sativa on the testicular function of first-generation offspring of mice treated with titanium oxide nanoparticles [PDF]
Avicenna Journal of Phytomedicine, 2023 Objective: Nanoparticles include primary particles with at least one of their dimensions being less than 100 nm. The goal of this research was to determine the possible protective role of Nigella sativa (NS) against toxic effects mediated by titanium ...
Morteza Abouzaripour +4 more
doaj +1 more source