Results 41 to 50 of about 3,533 (184)

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

A inserção brasileira no cenário nuclear: os caminhos e descaminhos ao TNP [PDF]

, 2013
TCC (Graduação) - Universidade Federal de Santa Catarina. Centro Socioeconômico. Curso de Graduação em Relações Internacionais.As descobertas atômicas trouxeram um novo olhar para as relações de poder entre os Estados.
Geraldo, Michelly Sandy
core  

Heritages in Museums and Museum Collections of National and Regional Parks and Protected Areas in Slovenia

Traditiones, 2015
V okviru raziskovalnega projekta Triglavski narodni park (TNP). Dediščine, akterji – strategije, vprašanja in rešitve je avtor opravil raziskavo o tem, kako se dediščina parka kaže, ustvarja in predstavlja različnim deležnikom TNP oziroma kako jo ti ...
Jože Hudales
doaj   +1 more source

Effect of extrusion on the crystallinity, viscosity, damage starch, and thermal properties of corn flour, masa, and tortilla

Applied Food Research, 2022
Nixtamalized products are very appreciated in México and the world; however, the traditional nixtamalization process (TNP) is highly polluting. Extrusion nixtamalization process (ENP) is an alternative method; however, much research reported high starch ...
Carlos M. Enríquez-Castro, Benjamín Ramírez-Wong, Brenda L. Contreras-Jiménez, Armando Quintero-Ramos, Juan de Dios Figueroa-Cárdenas, Francisco Vázquez-Lara   +5 more
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Introduction. Le TNP de Vilar : « Un mystère en pleine lumière » [PDF]

, 2015
« Un mystère en pleine lumière » : ainsi Jean Vilar qualifie-t-il le Théâtre National Populaire (désormais cité : TNP) qu’il a dirigé de 1951 à 1963. Le mystère, chose cachée, secrète, au caractère incompréhensible et obscur, contraste avec la visibilité
Fleury, Laurent
core   +1 more source

Reduced basal ganglia μ-opioid receptor availability in trigeminal neuropathic pain: A pilot study

Molecular Pain, 2012
Background Although neuroimaging techniques have provided insights into the function of brain regions involved in Trigeminal Neuropathic Pain (TNP) in humans, there is little understanding of the molecular mechanisms affected during the course of this ...
DosSantos Marcos, Martikainen Ilkka, Nascimento Thiago, Love Tiffany M, Deboer Misty, Maslowski Eric C, Monteiro André, Vincent Maurice, Zubieta Jon-Kar, DaSilva Alexandre F   +9 more
doaj   +1 more source

Membrane association of the Tnp and Inh proteins of IS50R [PDF]

Journal of Bacteriology, 1990
Using a radioimmunoassay for the IS50R proteins Tnp and Inh, we found that both proteins were present primarily in the cytoplasm, but 3 to 11% of Tnp and 3 to 5% of Inh were found in association with the inner membrane. The fractions of total Tnp and Inh that became membrane bound were unaffected by the amount of Tnp and Inh synthesized in whole cells,
A, DeLong, M, Syvanen
openaire   +2 more sources

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.

PLoS ONE, 2017
The pathological condition of multiple sclerosis (MS) relies on innate and adaptive immunity. New types of agents that beneficially modify the course of MS, stopping the progression and repairing the damage appear promising. Here, we studied TnP, a small
Evilin Naname Komegae, Tais Aparecida Matozo Souza, Lidiane Zito Grund, Carla Lima, Monica Lopes-Ferreira   +4 more
doaj   +1 more source