Results 41 to 50 of about 22,212 (273)

TNP-470 skews DC differentiation to Th1-stimulatory phenotypes and can serve as a novel adjuvant in a cancer vaccine

Blood Advances, 2018
: Fumagillin is an antiangiogenic and antineoplastic fungal natural product, and TNP-470 is one of its most potent analogs. Decades of studies revealed that TNP-470 has potent anticancer activities via destruction of neovasculature.
Derek Hoi-Hang Ho, Roger Hoi-Fung Wong
doaj   +1 more source

Binding of Trinitrophenol (TNP)-specific immunoglobulin free light chain (Ig-fLC) to TNP-conjugated ovalbumin (TNP-OVA) or TNP-conjugated bovine serum albumin (TNP-BSA) detected by immunoblotting.

, 2013
TNP-coated proteins, TNP-BSA (lane 3–5) or TNP-OVA (lane 8–10), or unconjugated controls (lane 2: BSA and 7:OVA) were subjected to SDS-PAGE and subsequently electroblotted to PVDF membrane. Membrane was incubated with TNP-kappa Ig-fLC (2 µg/ml) and bound
Bart R. Blokhuis (315023), Marco Thio (315020), Tom Groot Kormelink (315021), Frans P. Nijkamp (315024), Marcel J. Fischer (315022), Frank A. Redegeld (315025)   +5 more
core   +1 more source

TMA-TNP Design v1 [PDF]

, 2020
Human Tumor Atlas Tissue MicroArrary TNP (TMA-TNP) The Tissue MicroArray (TMA) TNP will extend the SARDANA-TNP characterization and analytics methodologies for evaluation and validation on a large array of breast tumor samples that provide a broad spectrum of disease state and subtype.
Heidi S Feiler, Koei Chin
openaire   +1 more source

Binding of TNP-specific fLC’s to immobilized TNP-OVA.

, 2013
TNP-OVA was coated to the surface of 96-well plates. Unbound TNP-OVA was washed away followed by blocking with PBS/1%BSA. TNP-specific Ig-fLC was added and binding of Ig-fLC was detected using anti-mouse kappa light chain Ab conjugated with HRP.
Bart R. Blokhuis (315023), Marco Thio (315020), Tom Groot Kormelink (315021), Frans P. Nijkamp (315024), Marcel J. Fischer (315022), Frank A. Redegeld (315025)   +5 more
core   +1 more source

No hypoperfusion is produced in the epicardium during application of myocardial topical negative pressure in a porcine model

Journal of Cardiothoracic Surgery, 2007
Background Topical negative pressure (TNP), commonly used in wound therapy, has been shown to increase blood flow and stimulate angiogenesis in skeletal muscle.
Malmsjö Malin, Lindstedt Sandra, Ingemansson Richard   +2 more
doaj   +1 more source

Real-time analysis of TNP-specific Ig-fLC binding to TNP-BSA coated SPR chips.

, 2013
Increasing concentrations of Ig-fLC (300 ng, 900 ng, 1.8 µg, 2.7 µg and 3.6 µg per CM5 sensor chip) resulted in increased binding curves (A). Administration of TNP-IgE (3.6 µg) resulted in significant binding to the TNP-coated surface and saturation ...
Bart R. Blokhuis (315023), Marco Thio (315020), Tom Groot Kormelink (315021), Frans P. Nijkamp (315024), Marcel J. Fischer (315022), Frank A. Redegeld (315025)   +5 more
core   +1 more source

Training registered nurses to conduct pre-implementation assessment to inform program scale-up: an example from the rural Transitions Nurse Program

Implementation Science Communications, 2021
Objectives Adapting evidence-based practices to local settings is critical for successful implementation and dissemination. A pre-implementation assessment evaluates local context to inform implementation, but there is little published guidance for ...
Chelsea Leonard, Heather Gilmartin, Marina McCreight, Lynette Kelley, Ashlea Mayberry, Robert E. Burke   +5 more
doaj   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Heritages in Museums and Museum Collections of National and Regional Parks and Protected Areas in Slovenia

Traditiones, 2015
V okviru raziskovalnega projekta Triglavski narodni park (TNP). Dediščine, akterji – strategije, vprašanja in rešitve je avtor opravil raziskavo o tem, kako se dediščina parka kaže, ustvarja in predstavlja različnim deležnikom TNP oziroma kako jo ti ...
Jože Hudales
doaj   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source