Results 41 to 50 of about 12,194 (224)

Binding of TNP-specific fLC’s to immobilized TNP-OVA.

, 2013
TNP-OVA was coated to the surface of 96-well plates. Unbound TNP-OVA was washed away followed by blocking with PBS/1%BSA. TNP-specific Ig-fLC was added and binding of Ig-fLC was detected using anti-mouse kappa light chain Ab conjugated with HRP.
Bart R. Blokhuis (315023), Marco Thio (315020), Tom Groot Kormelink (315021), Frans P. Nijkamp (315024), Marcel J. Fischer (315022), Frank A. Redegeld (315025)   +5 more
core   +1 more source

Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.

PLoS ONE, 2017
The pathological condition of multiple sclerosis (MS) relies on innate and adaptive immunity. New types of agents that beneficially modify the course of MS, stopping the progression and repairing the damage appear promising. Here, we studied TnP, a small
Evilin Naname Komegae, Tais Aparecida Matozo Souza, Lidiane Zito Grund, Carla Lima, Monica Lopes-Ferreira   +4 more
doaj   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Membrane association of the Tnp and Inh proteins of IS50R [PDF]

Journal of Bacteriology, 1990
Using a radioimmunoassay for the IS50R proteins Tnp and Inh, we found that both proteins were present primarily in the cytoplasm, but 3 to 11% of Tnp and 3 to 5% of Inh were found in association with the inner membrane. The fractions of total Tnp and Inh that became membrane bound were unaffected by the amount of Tnp and Inh synthesized in whole cells,
A, DeLong, M, Syvanen
openaire   +2 more sources

Reduced basal ganglia μ-opioid receptor availability in trigeminal neuropathic pain: A pilot study

Molecular Pain, 2012
Background Although neuroimaging techniques have provided insights into the function of brain regions involved in Trigeminal Neuropathic Pain (TNP) in humans, there is little understanding of the molecular mechanisms affected during the course of this ...
DosSantos Marcos, Martikainen Ilkka, Nascimento Thiago, Love Tiffany M, Deboer Misty, Maslowski Eric C, Monteiro André, Vincent Maurice, Zubieta Jon-Kar, DaSilva Alexandre F   +9 more
doaj   +1 more source

Regional Differences in U.S. Consumer Preferences for Native Woody Shrubs With Varying Aesthetic Characteristics

Agribusiness, EarlyView.
ABSTRACT Native plants offer a variety of aesthetic (e.g., fall colour, fruit, flowers) and functional benefits (e.g., pollinator friendly, wildlife friendly, water management). How these benefits influence consumer choice and perceived value of native versus introduced plants is not well understood.
Alicia Rihn, Ariana P. Torres, Sue Barton, Bridget K. Behe   +3 more
wiley   +1 more source

Shedding Light on the Drug–Target Prediction of the Anti-Inflammatory Peptide TnP with Bioinformatics Tools

, 2022
Peptide–protein interactions are involved in various fundamental cellular functions, and their identification is crucial for designing efficacious peptide therapeutics. Drug–target interactions can be inferred by in silico prediction using bioinformatics
Lima, Carla, Carla Lima, Lopes-Ferreira, Monica, Silas Fernandes Eto, Monica Lopes-Ferreira, Eto, Silas Fernandes   +5 more
core   +1 more source

Transparent and Multi‐Foldable Nanocellulose Paper Microsupercapacitors

Advanced Science, 2022
Despite the ever‐increasing demand for transparent power sources in wireless optoelectronics, most of them have still relied on synthetic chemicals, thus limiting their versatile applications.
Sang‐Woo Kim, Kwon‐Hyung Lee, Yong‐Hyeok Lee, Won‐Jae Youe, Jae‐Gyoung Gwon, Sang‐Young Lee   +5 more
doaj   +1 more source

Proinflammatory Epstein–Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens, Paula Terroba‐Navajas, Eline A.J. Willemse, Sabine Schädelin, Manuel Comabella, Christian Münz, Gordan Lauc, Yannic Bartsch, Jens Kuhle, Jan D. Lünemann   +9 more
wiley   +1 more source

Suppression of rhabdomyosarcoma growth by fumagillin analog TNP-470 [PDF]

International Journal of Cancer, 1996
The purpose of our study was to investigate a novel therapeutic approach for rhabdomyosarcoma (RMS) in an animal model. The pursuit of new therapeutic modalities for RMS is critically important since this type of tumor is the most common soft tissue sarcoma in children and because patients with metastatic disease may not be cured with current ...
T, Kalebic, M, Tsokos, L J, Helman
openaire   +2 more sources