Results 61 to 70 of about 3,533 (184)

TnP Peptide Suppresses Experimental Autoimmune Encephalomyelitis (EAE) in a Preclinical Mouse Model

Frontiers in Immunology, 2022
TnP is a family of patented synthetic peptides which is in a preclinical development stage with valuable potential therapeutic indication for multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system (CNS).
Carla Lima, Adolfo Luis Almeida Maleski, Jefferson Thiago Gonçalves Bernardo, Vitor Cataldi Zelli, Evilin Naname Komegae, Monica Lopes-Ferreira   +5 more
doaj   +1 more source

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

Anti‐NMDA receptor autoimmune encephalitis associated with ovarian teratoma: A case series and literature review

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 23-30, April 2025.
Abstract Autoimmune encephalitis is a group of disorders characterized by symptoms of dysfunction of the limbic and extra‐limbic systems that occur in association with antibodies against intracellular antigens, synapses, or proteins located on the surface of nerve cells. Anti‐NMDA (N‐methyl‐D‐aspartate) receptor encephalitis was first described in 2007
Pham Ba Nha, Nguyen Phuong Tu, Nguyen Viet Ha, Duong Thi Thu Hien, Nguyen Thi Thu Phuong, Nguyen Anh Son, Nguyen Tien Hoang   +6 more
wiley   +1 more source

Job satisfaction and perceived leadership behaviours among the Turkish national police department: A case study on Eskisehir police department [PDF]

, 2008
This research explores the management problems in the Turkish National Police Organisation (TNP) by assessing the perceived leadership behaviours and job satisfaction of police officers working at the Eskisehir Police Department in Turkey.
Yucel, Ali Bogachan
core  

Dual‐Functionality, Bio‐Friendly Artificial Muscles for Actuation and Motion Sensing in Smart Wearable Systems

Small, EarlyView.
This work presents a biofriendly carbon nanotube yarn artificial muscle operating either as an in‐air unipolar actuator or as a self‐powered ionotronic strain sensor. Using a non‐volatile eutectogel‐derived electrolyte, the system achieves up to 2.9% contraction and 0.5 mV/% strain sensing sensitivity.
Gabriela Ananieva, Cédric Vancaeyzeele, Giao T. M. Nguyen, Frédéric Vidal, Thuan Nguyen Pham Truong, Nils‐Krister Persson, Li Guo, Tommie Varekamp, Felix Dransfeld, Jasper Sikken, Bram Bicknese, Cédric Plesse   +11 more
wiley   +1 more source

Precisely Engineering Biomimetic Nanoparticles via Controlled Cell Membrane Coating

Small, EarlyView.
Precise engineering of cell membrane‐coated nanoparticles (CMNPs) requires coordinated control over particle size, coating integrity, and membrane leaflet orientation. This review integrates key synthesis parameters, assembly strategies, and analytical methods that govern these features, revealing how structural control underpins biomimetic function ...
Jie Lay Lim, Lingqing Zong, Wei Deng, Maria Kavallaris, Zi Gu   +4 more
wiley   +1 more source

Water-mediated protein-fluorophore interactions modulate the affinity of an ABC-ATPase/TNP-ADP complex [PDF]

, 2008
TNP-modified nucleotides have been used extensively to study protein-nucleotide interactions. In the case of ABC-ATPases, application of these powerful tools has been greatly restricted due to the significantly higher affinity of the TNP-nucleotide for ...
Smits, Sander H J, Schmitt, Lutz, Oswald, C., Holland, I. B., Jenewein, Stefan, Jenewein, S., Oswald, Christine, Schmitt, L., Smits, S. H., Holland, I Barry   +9 more
core   +1 more source

Fluorescence spectra of TNP-ATP bound to M. leprae HSP18. [PDF]

, 2015
(A) Fluorescence emission spectra of TNP-ATP alone (trace 1); TNP-ATP+HSP18 (trace 2); Addition of 0.25 mM ATP to the HSP18-TNP-ATP complex (trace 3). Protein concentration used was 2.5 μM and TNP-ATP concentration was 2.5 μM.
Sandip Kumar Nandi (713237), Ayon Chakraborty (713238), Anirban Bhunia (116360), Alok Kumar Panda (335270), Sougata Sinha Ray (713239), Rajiv Kumar Kar (473120), Ashis Biswas (335275)   +6 more
core   +1 more source

Polyglycolic Acid Polymer Versus Porcine Small Intestine Submucosa Graft After Plaque Incision in Peyronie's Disease: A Comparative Study

Andrology, EarlyView.
ABSTRACT Background Peyronie's disease (PD) with severe penile curvature often requires surgical correction through plaque incision and grafting (PIG). Objectives To compare surgical outcomes between polyglycolic acid polymer grafts and porcine small intestinal submucosa (SIS) grafts in patients undergoing PIG for PD.
Renan Trevisan Jost, Leonardo Seligra Lopes, Pedro Caetano Edler Zandoná, Jovânio Fernandes da Rosa, Pedro Fernandes Lessa, Felipe Placco Araujo Glina, Nívio Pascoal Teixeira, Sidney Glina   +7 more
wiley   +1 more source

Male Mice Heterozygous for Protamine 1 and Protamine 2 Are Infertile, Displaying Sperm Damage and Retention of Protamine 2 Precursors, Transition Proteins, and Histones

Andrology, EarlyView.
ABSTRACT Background During spermiogenesis, protamines (PRMs) replace histones to hypercondense and protect sperm DNA. Rodents and primates express two PRMs (PRM1 and PRM2). Alterations of species‐specific PRM ratios are associated with sub‐ or infertility in mice and humans.
Gina Esther Merges, Christoph Wiesejahn, Mar Domingo‐Lopez, Simon Schneider, Andjela Kovacevic, Lena Arévalo, Hubert Schorle   +6 more
wiley   +1 more source