Results 71 to 80 of about 22,212 (273)

Priming of peripheral lymph node B cells with TNP-Ficoll: Role of lymphokines in B cell differentiation

, 1992
We have previously shown that peripheral lymph node (PLN) B lymphocytes of adult DBA/ 25 mice failed to make an antibody responseto type 2 antigen TNP-Ficoll, but exhibited a good antibody response to type 1 antigen TNP-BruceNa abortus.
S.Niranjan Goud, Alan M. Kaplan, Kaplan, Alan M., Bondada, Subbarao, Bondada Subbarao, Goud, S. Niranjan   +5 more
core   +1 more source

TnP Peptide Suppresses Experimental Autoimmune Encephalomyelitis (EAE) in a Preclinical Mouse Model

Frontiers in Immunology, 2022
TnP is a family of patented synthetic peptides which is in a preclinical development stage with valuable potential therapeutic indication for multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system (CNS).
Carla Lima, Adolfo Luis Almeida Maleski, Jefferson Thiago Gonçalves Bernardo, Vitor Cataldi Zelli, Evilin Naname Komegae, Monica Lopes-Ferreira   +5 more
doaj   +1 more source

Crystallography of organic energetic materials: thermoelastic properties and equation of state

Acta Crystallographica Section B, EarlyView.
Thermoelastic properties and equation‐of‐state parameters of 16 organic energetic molecular crystals are systematically compiled and compared from temperature‐ and pressure‐dependent crystallographic data. The analysis highlights anisotropic thermal expansion and compressibility and identifies structural factors governing the mechanical response of ...
Mathieu Guerain
wiley   +1 more source

Water-mediated protein-fluorophore interactions modulate the affinity of an ABC-ATPase/TNP-ADP complex

, 2008
TNP-modified nucleotides have been used extensively to study protein-nucleotide interactions. In the case of ABC-ATPases, application of these powerful tools has been greatly restricted due to the significantly higher affinity of the TNP-nucleotide for ...
Smits, Sander H J, Schmitt, Lutz, Oswald, C., Holland, I. B., Jenewein, Stefan, Jenewein, S., Oswald, Christine, Schmitt, L., Smits, S. H., Holland, I Barry   +9 more
core   +1 more source

Polyurethane derivatives for highly sensitive and selective fluorescence detection of 2,4,6-trinitrophenol (TNP)

, 2018
A series of luminescent non-conjugated polyurethane derivatives (PUs) has been obtained in a facile way in high yields. The polymers show highly selective and sensitive detection of 2,4,6-trinitrophenol (TNP) (picric acid).
Nan Jiang, Guang-Fu Li, Weilong Che, Dong-Xia Zhu, Zhong-Min Su, M. Bryce   +5 more
semanticscholar   +1 more source

Male Mice Heterozygous for Protamine 1 and Protamine 2 Are Infertile, Displaying Sperm Damage and Retention of Protamine 2 Precursors, Transition Proteins, and Histones

Andrology, EarlyView.
ABSTRACT Background During spermiogenesis, protamines (PRMs) replace histones to hypercondense and protect sperm DNA. Rodents and primates express two PRMs (PRM1 and PRM2). Alterations of species‐specific PRM ratios are associated with sub‐ or infertility in mice and humans.
Gina Esther Merges, Christoph Wiesejahn, Mar Domingo‐Lopez, Simon Schneider, Andjela Kovacevic, Lena Arévalo, Hubert Schorle   +6 more
wiley   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

Cell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng, Yuxiu Lin, Yongyan Gao, Delan Huang, Yuanyuan Li, Honglei Ruan, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
wiley   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

The trimeric Shu complex in C. elegans is an ATPase that remodels RAD51 filaments in the homologous recombination‐associated DNA damage response

The FEBS Journal, EarlyView.
The C. elegans Shu complex (RFS‐1/RIP‐1/SWS‐1) is a DNA‐dependent ATPase that regulates RAD‐51 filaments during homologous recombination. The trimer preferentially binds 5′‐exposed DNA, remodels RAD‐51 filaments via ATP hydrolysis, and stabilizes filaments through ATP binding.
Sam Siu Hang Chu, Guangxin Xing, Kichang Paik, Anton Gartner, Hong Ling   +4 more
wiley   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source