Results 71 to 80 of about 60,670 (282)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Cancer pattern in Bhutan (2014–2022): Findings from population‐based cancer registry—A pathway to monitor cancer control activities

International Journal of Cancer, EarlyView.
What's New? The establishment in 2014 of the population‐based cancer registry (PBCR) of Bhutan created new opportunities for understanding national cancer trends, which previously were anticipated from data in neighbouring countries. This study presents the first nine‐year summary of cancer patterns in Bhutan, derived from PBCR data. From 2014 to 2022,
Phub Tshering, Ugyen Tshomo, Meera Chetri, Sumitra Suberi, Yangdon Yangdon, Laigden Dzed, Tshewang Lhadon, Sonali Bagal, Sharyu Mhamane, Atul Budukh   +9 more
wiley   +1 more source

Perceptions about the harm of secondhand smoke exposure among U.S. middle and high school students: findings from the 2012 National Youth Tobacco Survey

Tobacco Induced Diseases, 2013
Background Increased knowledge of the harmful effects of SHS is an evidence-based key indicator for eliminating nonsmokers’ exposure to SHS. This study assessed the prevalence and predictors of perceptions about the harm of secondhand smoke (SHS ...
Brian A. King, Shanta R Dube, Stephen D. Babb   +2 more
doaj   +1 more source

Predicting smokers' non-compliance with smoking restrictions in public places [PDF]

, 2009
Objective: The present study aimed to identify the predictors of non-compliance with smoking restrictions among Greek college student smokers. Differences in attitudes to smoking bans and tobacco control policies between current smokers and non-smokers ...
Eiser, J.R., Lazuras, L., Rodafinos, A.
core   +1 more source

Ambient Particulate Air Pollution, Environmental Tobacco Smoking, and Childhood Asthma: Interactions and Biological Mechanisms [PDF]

American Journal of Respiratory and Critical Care Medicine, 2011
The World Health Organization (WHO) estimates that 24% of the global burden of disease is caused by environmental factors that can be averted (1). Understanding the role of the environment in asthma is a natural ambition in the overall search to understand environmental burdens: In an individual expressing the asthmatic phenotype, worsening of asthma ...
A. Baccarelli, J. D. Kaufman
openaire   +2 more sources

Move beyond free radical theory of aging

iMetaOmics, EarlyView.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

PDCD5 Contributes to Airway Epithelial Cell Damage via Mitochondrial Pathway and Participates in COPD Pathogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Airway epithelial injury plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction is implicated in this injury, while the underlying mechanism remains incompletely understood. RNA sequencing was conducted to identify key genes involved in mitochondrial dysfunction in airway epithelial
Hu Shan, Rui Zhang, Yu‐er Li, Rui Li, Shao‐bo Ge, Jin Liu, Shi‐yuan Yao, Xia Yang, Tao Zhang, Ming Zhang   +9 more
wiley   +1 more source

Siekgebou-indroom - 'n krietiese oorsig

Clean Air Journal, 1991
Worldwide, indoor air pollution is causing great concern. Because is often the only visible air pollutant, tobacco smoke is invariably singled out as the culprit. However, detailed research has found that it plays an insignificant role and that the blame
C Leijeaar
doaj   +1 more source

Passive smoking and type 2 diabetes among never‐smoking women: The Japan Public Health Center‐based Prospective Study

Journal of Diabetes Investigation, 2020
Aims/Introduction The aim of the current study was to prospectively evaluate the association between passive smoking from a spouse and the risk of diabetes among never‐smoking Japanese women.
Shino Oba, Atsushi Goto, Tetsuya Mizoue, Manami Inoue, Norie Sawada, Mitsuhiko Noda, Shoichiro Tsugane   +6 more
doaj   +1 more source

Spirometry in fuel station attendants : a comparative study [PDF]

, 2015
Exposure to volatile fuel compounds and roadway motor vehicle exhaust leads to increased risk of chronic lung disease and carcinogenesis. Tobacco smoking further accelerates this process. Spirometry is an objective way of assessing lung function. The aim
Borg, Manwel, Vella, Jacob
core