Results 91 to 100 of about 86,485 (257)

Tocilizumab, a humanized anti-interleukin-6 receptor antibody, for treatment of rheumatoid arthritis

, 2011
Masahiko Mihara1, Yoshiyuki Ohsugi2, Tadamitsu Kishimoto31Product Research Department, Chugai Pharmaceutical Co Ltd, Fuji-Gotemba Research Laboratories, Shizuoka, Japan; 2Chugai Pharmaceutical Co Ltd, Tokyo, Japan; 3Laboratory of Immunoregulation ...
Masahiko Mihara, Yoshiyuki Ohsugi, Tadamitsu Kishimoto   +2 more
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Tocilizumab(TCZ)使用前後の末梢血トランスクリプトームの変化とTCZ使用中に多彩な皮膚病変をきたした一例 [PDF]

, 2018
Tocilizumab(TCZ)(IL-6阻害薬)による皮疹の副作用については、あまり注目されてこなかった。今回我々はTCZ使用と、重篤な皮膚病変の出現との関連を強く疑わせる症例を経験した。症例は59歳男性、関節リウマチ(RA)に対し、TCZを開始した。その後皮疹が出現し始め、白血球破砕性血管炎の診断に至った。中等量PSL併用後も新たに好中球性皮膚症を発症し、ジアフェニルスルホン(DDS)を追加し寛解していたが、これら薬剤の減量中に再燃し重症化した。ステロイドパルス+高用量PSLを開始したが ...
妹尾, 明美, 樋口, 俊恵, 山口, 麻里, 深松, 伸明, 高木, 徹, 小山, 芳伸, 田村, 麻衣子, 佐藤, 慶治, 別所, 昭宏, 大槻, 花穂   +9 more
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Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Biologic and Targeted Synthetic Disease‐Modifying Antirheumatic Drugs Do Not Arrest Bone Loss in Patients With Rheumatoid Arthritis: A Long‐Term Multicenter Observational Study

Arthritis &Rheumatology, EarlyView.
Objective Osteoporosis causes fractures that further increase the disease burden of rheumatoid arthritis (RA); however, osteoporosis treatment rates remain low. Although several studies have reported that biologic or targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) can prevent or improve osteoporosis in RA, our large‐scale, real ...
Takafumi Aritomi, Koshiro Sonomoto, Shingo Nakayamada, Hiroaki Tanaka, Atsushi Nagayasu, Satoshi Kubo, Ippei Miyagawa, Ayako Yamaguchi, Naoaki Ohkubo, Yasuyuki Todoroki, Yurie Satoh‐Kanda, Masanobu Ueno, Ryuichiro Kanda, Yuya Fujita, Masashi Funada, Hidenori Sakai, Satsuki Matsunaga, Hiroaki Tanaka, Masayuki Shinojima, Hiroki Kawamura, Kazuki Takahashi, Miyabi Ando, Kazuki Haru, Yusuke Miyazaki, Kentaro Hanami, Masao Nawata, Shunsuke Fukuyo, Keisuke Nakatsuka, Mikiko Tokunaga, Kazuyoshi Saito, Yoshiya Tanaka   +30 more
wiley   +1 more source

Tocilizumab in Giant Cell Arteritis

, 2018
Giant cell arteritis is a granulomatous immune-mediated vasculitis of medium and large vessels. It most commonly affects Caucasian females over the age of 50 and is the most common primary vasculitis in the United States.
William H. Frishman, Mariano, Vincent, Vincent J. Mariano, Frishman, William H.   +3 more
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Coverage Generosity of Novel Antirheumatic Drugs in Medicare Advantage and Stand‐Alone Part D Plans

Arthritis &Rheumatology, EarlyView.
Objective We examine coverage of self‐administered disease‐modifying antirheumatic drugs (DMARDs) in Medicare Part D. Methods Using 2022–2026 Part D formulary data, we assessed coverage of the following DMARD classes that treat relapsed rheumatoid arthritis (RA): tumor necrosis factor (TNF) inhibitors, T cell costimulatory modulator, interleukin‐6 (IL ...
Youngmin Kwon, Robert W. Corty, Stacie B. Dusetzina   +2 more
wiley   +1 more source

Histological Assessment of Respiratory Tract and Liver of BALB/c Mice Nebulized with Tocilizumab

Pulmonary drug delivery offers a minimally invasive and efficient method for treating lung conditions, leveraging the lungs’ extensive surface area and blood flow for rapid drug absorption.
Henriquez-Camacho, César, García, Almudena, Ferreiro, Sergio, Andrés Gamazo, Paloma Jimena de, Flores, Ángela   +4 more
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Tocilizumab-associated multifocal cerebral thrombotic microangiopathy [PDF]

, 2016
Tocilizumab is a humanized monoclonal antibody that targets the interleukin-6 receptor (IL-6-R). It is approved for use in moderate to severe refractory rheumatoid arthritis and more recently has been found to be effective in treating neuromyelitis ...
Jewell, Paul, Irani, Sarosh R., ZAMBONI, Giovanna, Jewell, P, Kuker, Wilhelm, Irani, S, Irani, Sarosh, Ansorge, Olaf, Ansorge, O, Kuker, W, Zamboni, G   +10 more
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Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, CH of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA) and whether ...
Kun Zhao, Yash Pershad, J. Brett Heimlich, Michelle Ormseth, C. Michael Stein, Brian Sharber, Caitlyn Vlasschaert, Alexander G. Bick, Robert W. Corty   +8 more
wiley   +1 more source

Tocilizumab Reduces Depression Risk in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis [PDF]

Leena R Baghdadi Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Leena R Baghdadi, Email baghdadi@ksu.edu.saAbstract: Depression is a possible cause of the increased mental ...
Baghdadi LR
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