Results 101 to 110 of about 100,944 (279)

Brief Summary of Potential SARS-CoV-2 Prophylactic and Treatment Drugs in the Emergency Department [PDF]

, 2020
As of March 30th, 2020 there were 161,807 total cases and 2,953 total deaths of SARS-CoV-2 in the United States, with the number of cases expected to rise.
Brown, Cortlyn, Coralic, Zlatan, Noble, Jeanne   +2 more
core  

Severe sepsis caused by Aeromonas hydrophila in a patient using tocilizumab: a case report [PDF]

, 2011
Introduction Aeromonas species do not commonly cause disease in humans. However, when disease is seen, it often occurs in patients with underlying immunosuppression or malignancy and has a high fatality rate.
Kenji Okumura, Fumihiro Shoji, Masaki Yoshida, Atsushi Mizuta, Ichiro Makino, Hidefumi Higashi   +5 more
core   +2 more sources

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Cost-effectiveness analysis of tocilizumab in combination with methotrexate for rheumatoid arthritis: A Markov model based on data from Serbia, country in socioeconomic transition [PDF]

, 2014
Background/Aim. Recent studies have shown that biological treatments for rheumatoid arthritis can change the course of rheumatoid arthritis and improve functional ability of patients with rheumatoid arthritis.
Janković Slobodan M., Jovanović Snežana, Kostić Marina, Popović-Milenković Marija, Tomović Marina   +4 more
core   +1 more source

The Clinical Value of Inflammatory Indicators at the Time of Secondary Infection After Treatment With Tocilizumab: A Cross‐Sectional Study

Health Science Reports
Background and Aims Tocilizumab, an anti‐inflammatory agent used in severe COVID‐19 infection, is known to inhibit the Interleukin 6 receptor and reduce C‐reactive protein (CRP) resulting in an increased risk of secondary infections.
Dena Firouzabadi, Amirreza Dehghanian, Sahar DehghanKhalili, Saeed DehghanKhalili, Seyed Mohammad Hosseini Saadi   +4 more
doaj   +1 more source

Defining the optimal biological monotherapy in rheumatoid arthritis: a systematic review and meta-analysis of randomised trials [PDF]

, 2016
Objectives To summarize and compare the benefits and harms of biological agents used as monotherapy for rheumatoid arthritis (RA) in order to inform decisions for patients who are intolerant to conventional DMARD therapy.
Bliddal, Henning, Boers, Maarten, Choy, Ernest Ho Sing, Christensen, Robin, Dossing, Anna, Furst, Daniel E., Hansen, Michael S., Kristensen, Lars E., Lorenzen, Tove, Singh, Jasvinder A., Suarez-Almazor, Maria E., Tarp, Simon, Østergaard, Mikkel   +12 more
core   +2 more sources

Interleukin‐18 Levels Are Associated With Disease Course in Patients With Still Disease Treated With Interleukin‐1 Inhibitors

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the prognostic utility of circulating interleukin‐18 (IL‐18) levels in predicting disease activity, macrophage activation syndrome (MAS), and disease course in patients with Still disease (SD) receiving first‐line IL‐1 inhibitors (IL‐1i).
Matteo Trevisan, Manuela Pardeo, Ivan Caiello, Claudia Bracaglia, Arianna De Matteis, Valentina Matteo, Elena Loricchio, Fabrizio De Benedetti, Giusi Prencipe   +8 more
wiley   +1 more source

Rheumatoid arthritis and spondyloarthropathy [PDF]

, 2013
Part 2 of the article can be found through this link: https://www.um.edu.mt/library/oar//handle/123456789/13280Rheumatoid arthritis (RA) and spondyloarthropathy are two groups of inflammatory joint disease.
Vassallo, Pierre
core  

Long‐Term Outcomes of Reduced‐Intensity Conditioning Hematopoietic Stem Cell Transplantation for Patients With Systemic Sclerosis With Impaired Cardiac Function

Arthritis &Rheumatology, EarlyView.
Objective High‐intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced systemic sclerosis (SSc). The role of reduced‐intensity conditioning (RIC) before AHSCT in this population remains unclear.
Yonatan Lean, Carrie Richardson, Anthony J. Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

An exploratory analysis of associations of genetic variation with the efficacy of tocilizumab in severe COVID-19 patients. A pharmacogenetic study based on next-generation sequencing

Frontiers in Pharmacology
BackgroundIn the context of the cytokine storm the takes place in severe COVID-19 patients, the Interleukin 6 (IL6) pathway emerges as one of the key pathways involved in the pathogenesis of this hyperinflammatory state.
Alejandro Durán-Sotuela, Jorge Vázquez-García, Sara Relaño-Fernández, Vanesa Balboa-Barreiro, Juan Fernández-Tajes, Francisco J. Blanco, Francisco J. Blanco, Ignacio Rego-Pérez   +7 more
doaj   +1 more source