Results 121 to 130 of about 100,944 (279)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Adherence in Rheumatoid Arthritis patients assessed with a validated Italian version of the 5-item compliance questionnaire for rheumatology [PDF]

, 2019
OBJECTIVES: The 5-item Compliance Questionnaire for Rheumatology (CQR5) proved reliability and validity in respect of identification of patients likely to be high adherers (HAs) to anti-rheumatic treatment, or low adherers (LAs), i.e ...
Astorri, D., Azzolina , D., Botsios, C., Done, John, Doria, A, Favero, M, Friso, L, Gregori, D, Ometto, Francesca, Raffeiner, B.   +9 more
core  

Financial Toxicity Associated with Biological Medicines: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Financial toxicity, defined as the economic burden experienced by patients due to medication and other healthcare costs and their consequences, such as material, psychosocial and behavioral effects, represents a significant concern for individuals receiving biological medicines.
Laura Sara Maria Saarukka, Kamilla Yamileva, Kari Linden, Anniina Simonen, Anna‐Riia Holmström   +4 more
wiley   +1 more source

Carbon Footprint of Antibody‐Based Drugs and Biologics Using Hybrid Life Cycle Assessment

Clinical Pharmacology &Therapeutics, EarlyView.
Life cycle assessment of monoclonal antibodies. Biological engineering has emerged since the 1980s as one of the most efficient technologies to develop new medicines. The monoclonal antibody platform is the most widely used, representing about 15–20% of drug sales.
Sébastien Taillemite, Martin Fenelon, Marc Scherlinger, Max Piffoux   +3 more
wiley   +1 more source

High Mortality Rate in Severe COVID-19 Despite Tocilizumab Administration: A Case Series

JKS (Jurnal Kedokteran Syiah Kuala)
Introduction: Tocilizumab is a potential therapeutic agent for modulating cytokine storms, a known cause of multiorgan failure and mortality in severe COVID-19.
Cokorda Agung Wahyu Purnamasidhi, Ida Bagus Yorky Brahmantya, Saktivi Harkitasari, I Gusti Ngurah Mahaalit Aribawa, I Ketut Agus Somia   +4 more
doaj   +1 more source

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

The clinical effectiveness and cost-effectiveness of abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis: a systematic review and economic evaluation

, 2016
Background: Juvenile idiopathic arthritis (JIA) is characterised by joint pain, swelling and limitation of movement caused by inflammation. Subsequent joint damage can lead to disability and growth restriction.
Abbvie, Albarouni, All Wales Medicines Strategy Group, All Wales Medicines Strategy Group, All Wales Medicines Strategy Group, All Wales Medicines Strategy Group, Angeles-Han, Arthritis Care, Arthritis Care, Arthritis Care, Arthritis Care, Arthritis Research UK, Baildam, Baildam, Barton, Baszis, Bechtold, Berard, Bertilsson, Briggs, Briggs, Bristol-Myers Squibb, British Society for Paediatric and Adolescent Rheumatology, British Society for Paediatric and Adolescent Rheumatology, Brodszky, Brunner, Brunner, Brunner, Brunner, Brunner, Bruns, Bucher, Burgos-Vargas, Burgos-Vargas, Burgos-Vargas, Burgos-Vargas, Burgos-Vargas, Burgos-Vargas, Canadian Agency for Drugs and Technologies in Health, Chang, Chen, Connock, Consolaro, Consolaro, Consolaro, Consolaro, Cordero-Coma, Costa, Cummins, Cummins, Curtis, Dakin, De Benedetti, De Benedetti, Department of Health, Dias, Diaz-Llopis, Donegan, Drummond, Duffy, European Medicines Agency, European Medicines Agency, European Medicines Agency, European Medicines Agency, Feeny, Foeldvari, Gani, Garcia-De-Vicuna, Geikowski, Giannini, Glenny, Haapasaari, Heiligenhaus, Hendry, Higgins, Higgins, Horizon Scanning Centre, Horneff, Horneff, Imagawa, Joint Formulary Committee, Kearsley-Fleet, Kearsley-Fleet, Kemper, Khan, Kingsbury, Klein, Kuhlthau, Lloyd Jones, Lovell, Lovell, Lovell, Lovell, Lovell, Lovell, Lovell, Lovell, Luca, Luca, Lundkvist, Magli, Malottki, Martin, McErlane, McErlane, Mills, Minden, Minden, Monthly Index of Medical Specialties, Moorthy, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Rheumatoid Arthritis Society, National Rheumatoid Arthritis Society (NRAS), NHS England Clinical Reference Group for Paediatric Medicine, NHS England Specialised Services Clinical Reference Group for Specialised Ophthalmology, Nikolakopoulou, Office for National Statistics, Otten, Otten, Packham, Paediatric Formulary Committee, Parsons, Pennington, Petty, Pfizer Ltd, Philips, Prakken, Prince, Prince, Prince, Prince, Ramanan, Ravelli, Ravelli, Reeves, Riemsma, Rigante, Roche, Ruperto, Ruperto, Ruperto, Ruperto, Ruperto, Ruperto, Ruperto, Simonini, Simonini, Simpson, Simpson, Simpson, Smith, Sonnenberg, Stagi, Stevenson, Thierry, Thomson, Thornton, Tong, Tse, Tynjala, Ungar, Ungar, Vidqvist, Wallace, Wallace, Wallace, Yagudina, Zannin, Zeng   +171 more
core   +1 more source

Long‐term outcomes of children with ulcerative colitis after acute severe colitis: A GETAID pédiatrique multicenter study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Acute severe colitis (ASC) is a frequent and severe complication of ulcerative colitis (UC) with a high risk of colectomy. Effects of immunosuppressants and anti–tumor necrosis factor (anti‐TNF) agents on the risk of colectomy remain debated. We wished to study the evolution of French pediatric‐onset UC patients after ASC.
Manon Cochet, Agathe Beauvais, Frank Ruemmele, Raphael Enaud, Thierry Lamireau, Rémi Duclaux‐Loras, Claire Dupont, Stéphanie Willot, Laure Bridoux‐Henno, Georges Dimitrov, Julie Lemale, Vincent Guinard‐Samuel, Valérie Bertrand, Anne Breton, Christine Martinez Vinson, Stéphanie Coopman, Delphine Ley, Bénédicte Pigneur, and the Groupe d'Etudes Thérapeutiques des Affections Inflammatoires du tube Digestif (GETAID) pédiatrique   +18 more
wiley   +1 more source

Successfully performed video capsule endoscopy in an 8‐month‐old infant weighing 7.5 kg

JPGN Reports, EarlyView.
Abstract Video capsule endoscopy (VCE) is a well‐established diagnostic tool for examining the small bowel. Limited data exist on its use in infants. To our knowledge, we present the first detailed case of a successful PillCam®SB3‐VCE performed in an 8‐month‐old infant weighing 7.5 kg with suspected small bowel bleeding following allogeneic ...
Paul‐Christoph Zeisler, Robert Thimme, Ulrike Teufel‐Schaefer, Michael Schultheiß   +3 more
wiley   +1 more source