Results 141 to 150 of about 99,677 (264)
NEMO‐NDAS: Case Report and Review of the Literature
Pediatric Dermatology, EarlyView.ABSTRACT NEMO‐deleted exon 5 autoinflammatory syndrome (NEMO‐NDAS) is the result of a gain‐of‐function IKBKG pathogenic variant leading to dysregulated NF‐κB signaling and systemic inflammation. We present a case of NEMO‐NDAS in a 2‐year‐old female presenting with recurrent fevers, subcutaneous nodules, lymphadenopathy, and splenomegaly.
Angela Yang +5 more
wiley +1 more source
HHV‐8/KSHV in Solid Organ Transplantation: Current Gaps of Knowledge and Future Directions
Transplant Infectious Disease, EarlyView.Risk mitigation strategies, including donors/recipients screening, DNAemia monitoring in recipients at risk, CNI‐to‐mTOR inhibitors switch, antivirals, and rituximab for KICS, may mitigate the impact of HHV‐8/KSHV infection in SOT. This review provides an update on KICS, identifies research gaps, and summarizes advances in screening and management ...
Alessandra Mularoni +9 more
wiley +1 more source
American Journal of Hematology, Volume 101, Issue 4, Page 718-727, April 2026.ABSTRACT Sickle cell disease (SCD) is a chronic inflammatory state, characterized by increased plasma values of inflammatory and angiogenic proteins. Although red blood cell (RBC) transfusion is known to have immunomodulatory effects in other conditions, its potential effects on the inflammatory state in SCD remain largely unknown.
Lydian A. de Ligt +9 more
wiley +1 more source
Cancer Innovation, Volume 5, Issue 2, April 2026.Chimeric antigen receptor (CAR) T‐cell therapy, although revolutionary for haematological malignancies, faces significant challenges, including T‐cell exhaustion, limited persistence, and treatment‐related toxicity. The integration of small‐molecule compounds offers a promising strategy to overcome these limitations.
Rangzi Yi +3 more
wiley +1 more source
Phase 1 results of ZUMA-1: A multicenter study of KTE-C19 anti-CD19 CAR T cell therapy in refractory aggressive lymphoma [PDF]
, 2017 Bartlett, Nancy L +2 more
core +2 more sources
Basophil Activation Test for the In Vitro Diagnosis of Tocilizumab Hypersensitivity
Clinical &Experimental Allergy, EarlyView.
Ana Koren +3 more
wiley +1 more source
The role of T cells in sepsis of distinct infectious aetiologies
Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.Pathogen‐specific sepsis induces mitochondrial dysfunction in T cells, leading to functional alterations. Single‐cell transcriptomics reveals subtype‐specific impairments involving reactive oxygen species accumulation, mtDNA damage, calcium dysregulation, and metabolic reprogramming.
Xuanqi Liu +5 more
wiley +1 more source
eJHaem, Volume 7, Issue 2, April 2026.ABSTRACT We report a case of delayed hypersensitivity dermatitis and an unusual lymphocyte expansion peaking at 45,000 cells/µL by Day +14 after ciltacabtagene autoleucel, a BCMA‐targeted CAR T therapy for multiple myeloma (MM). This marked post‐infusion lymphocytosis was initially mistaken for plasmacytosis but was confirmed by flow cytometry to be ...
Jack Shapiro +9 more
wiley +1 more source
MedComm, Volume 7, Issue 4, April 2026.CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley +1 more source
Distinct Pattern of Atypical Megakaryocytes in VEXAS Syndrome
International Journal of Laboratory Hematology, EarlyView.
Andrew Y. Sung +4 more
wiley +1 more source