Results 41 to 50 of about 86,485 (257)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Takayasu arteritis in childhood: retrospective experience from a tertiary referral centre in the United Kingdom. [PDF]

, 2015
Takayasu arteritis (TA) is an idiopathic large-vessel vasculitis affecting the aorta and its major branches. Although the disease rarely affects children, it does occur, even in infants.
McMahon, AM, Paul A Brogan, Pavla Dolezalova, Giulia Varnier, Despina Eleftheriou, Eleftheriou, D, Varnier, G, Muthana Al-Obaidi, Al-Obaidi, M, Dolezalova, P, Brogan, PA, Anne-Marie McMahon   +11 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Impact of three consecutive intravenous doses of tocilizumab in severe COVID-19 pneumonia: a retrospective cohort study

Microbes, Infection and Chemotherapy, 2021
Background. Acute respiratory distress syndrome (ARDS) in severe COVID-19 pneumonia is mostly responsible for high mortality rate. Tocilizumab, an interleukin-6 (IL-6) inhibitors, down-regulates the progression of cytokine storm leading to ARDS ...
Raihan Rabbani, Md Jahidul Hasan, Ahmad Mursel Anam, Shihan Mahmud Redwanul Huq   +3 more
doaj   +1 more source

Successful Tocilizumab Treatment for Scleritis [PDF]

, 2019
Purpose: To present a rare case of scleritis associated with a prior diagnosis of giant cell arteritis (GCA) that was unresponsive to glucocorticoids, nonsteroidal anti-inflammatory drugs (NSAIDs), methotrexate, and azathioprine, but reached and ...
van Daele, Paul, Rothova, Aniki, Daele, P.L.A. (Paul) van, Poelman, H.J. (Huub J.), van Daele, Paul; id_orcid, Rothová, A. (Aniki), Poelman, Huub   +6 more
core   +2 more sources

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

A Pilot Study on Tocilizumab in Very-Late-Onset Myasthenia Gravis

, 2023
Ting-Ting Yang,1,* Ze-Yi Wang,1,* Ze-Xin Fan,1 Bo-Yi Yuan,1 Lin Ma,1 Jian-Feng Lu,1 Pen-Ju Liu,1 Yang He,2 Guang-Zhi Liu1 1Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, People’s Republic of China ...
Yang TT, Ma L, He Y, Yuan BY, Liu GZ, Fan ZX, Lu JF, Wang ZY, Liu PJ   +8 more
core  

Trial of Tocilizumab in Giant-Cell Arteritis [PDF]

, 2017
BACKGROUND: Giant-cell arteritis commonly relapses when glucocorticoids are tapered, and the prolonged use of glucocorticoids is associated with side effects.
Tuckwell, Katie, Cid, Maria C, Schett, Georg, Katie Tuckwell, Brouwer, Elisabeth, Carlo Salvarani, Stone, John H, Robert Spiera, Daniel Blockmans, Schulze Koops, Hendrik, Georg Schett, Sebastian H. Unizony, Dimonaco, Sophie, Unizony, Sebastian H., Sophie Dimonaco, Collinson, Neil, Blockmans, Daniel Engelbert, Aringer, Martin, Blockmans, Daniel, Hendrik Schulze-Koops, Unizony, Sebastian H, John H. Stone, Martin Aringer, Neil Collinson, Schulze-Koops, Hendrik, Micki Klearman, Bhaskar Dasgupta, Klearman, Micki, Elisabeth Brouwer, Maria C. Cid, Spiera, Robert, Cid, Maria C., Rech, Juergen, Stone, John H., Salvarani, Carlo, Dasgupta, Bhaskar, Juergen Rech   +36 more
core   +2 more sources

Associations of Rheumatoid Arthritis Disease Activity With Frailty Over Five Years of Follow‐up

Arthritis Care &Research, EarlyView.
Objective To evaluate whether rheumatoid arthritis (RA) disease activity is associated with frailty both in cross‐section and longitudinally. Methods Participants within the Veterans Affairs Rheumatoid Arthritis (VARA) registry enrolled from 2003 to 2022 were included.
Courtney N. Loecker, Yangyuna Yang, Punyasha Roul, Aaron Baraff, Myra S. Schmaderer, Lani Zimmerman, Kaleb Michaud, Namrata Singh, Grant W. Cannon, Gary Kunkel, Ted R. Mikuls, Ariela R. Orkaby, Joshua F. Baker, Bryant R. England, Katherine D. Wysham   +14 more
wiley   +1 more source