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The Safety and Efficacy of Tocolytic Agents for the Treatment of Preterm Labor
Obstetrical & Gynecological Survey, 1990Pharmacologic inhibition of uterine contractions remains the mainstay of treatment for preterm labor despite the ongoing controversy regarding its effectiveness. A diverse variety of tocolytic medications have been proposed for clinical use, with betamimetics and magnesium sulfate being the common therapeutic agents of choice in the United States today.
R E, Besinger, J R, Niebyl
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Progesterone as a tocolytic agent for preterm labor: a systematic review
Current Opinion in Obstetrics & Gynecology, 2016Purpose of review Tocolytic agents have been used for over 60 years in the fight against preterm labor, which ultimately can lead to preterm birth. Currently, clinicians can choose from a variety of drug classes to achieve the primary goal of delaying delivery by 48 h, thereby allowing time for administration of corticosteroids
Reshama, Navathe, Vincenzo, Berghella
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Long-Term Use of Magnesium Sulfate as a Tocolytic Agent
Obstetrics & Gynecology, 1986Two patients in premature labor were treated continuously for six and 13 weeks with intravenous magnesium sulfate (MgSO4) for tocolysis. In each case, conventional therapy with intravenous and oral ritodrine failed to abate uterine contractions, and attempts to taper the MgSO4 were unsuccessful.
I A, Wilkins +5 more
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Prevention and Tocolytic Agents 2
2019Preterm birth is the single most important determinant of adverse infant outcomes, in terms of survival and quality of life. Preterm infants are particularly vulnerable to complications with the increasing contribution of neonatal deaths to overall child mortality.
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Efficacy and side effects of magnesium sulfate and ritodrine as tocolytic agents
American Journal of Obstetrics and Gynecology, 1988Ritodrine as the first-line drug in the treatment of established preterm labor has been supplanted in some centers by magnesium sulfate. To assess the relative efficacy and rates of side effects of these two agents, 120 patients were randomly assigned to receive one of these two drugs.
I A, Wilkins +4 more
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Ritodrine and nifedipine as tocolytic agents: a preliminary comparison.
Journal of perinatal medicine, 1996The effectiveness of the tocolytic agent and other betamimetic drugs in the treatment of preterm labor remains controversial. Effectiveness or efficancy of ritodrine has not yet convincingly been proven. A major concern are the marked side effects of beta-mimetics.
K G, van Dijk +2 more
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[Calcium antagonists in pregnancy as an antihypertensive and tocolytic agent].
Wiener medizinische Wochenschrift (1946), 1994In pregnancy calcium antagonism is of great importance. The uterus-relaxing properties of verapamil are well known, diltiazem shows an excellent tokolytic efficacy and is also effective as hypotensive in pregnancy-induced hypotension. In contrast to verapamil and diltiazem the dihydropyridines were not clinically successful as tokolytic or hypotensive ...
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Interval to delivery in high-risk patients: do tocolytic agents really work?
International Journal of Gynecology and Obstetrics, 1992J C Morrison
exaly