Tocolytic agents and the failure to improve neonatal outcomes
PregnancyPremature delivery has long been a major problem in obstetrics. Increased perinatal morbidity and mortality as well as substantial health care costs, both short and long term, have driven the efforts to combat this complication.
Jack FitzSimmons, Emily Oliver
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Effects of sympathomimetic tocolytic agents on the fetus [PDF]
Journal of Perinatal Medicine, 1974 The variety of factors controlling the onset of parturition, as well as the very complex mechanisms which physiologically maintain pregnancy by inhibiting uterine contractions are only partially understood today. As long as the triggering mechanisms, and the conditions favoring timely and early labor are incompletely known, symptomatic therapeutic ...
V. Unbehaun
openaire +3 more sources
Preventing Preterm Birth: The Search for Tocolytic Synergism. [PDF]
Reprod SciPreterm birth is a common cause of neonatal mortality and morbidity, which are increasingly prevalent today. Preterm birth affects millions of babies worldwide and is the subject of intense study in its pathophysiology and therapy.
Hossain MR +4 more
europepmc +2 more sources
Assessing Tocolytic Potency: Variability and Accuracy of AUC Versus Amplitude-Based Assessment of Pregnant Human Myometrial Contractions Ex Vivo. [PDF]
Reprod SciThe methodological approaches used to evaluate the inhibitory effects (potency determination) of tocolytic agents on human uterine contractions in ex vivo systems vary, and none of the methodologies has been subjected to scrutiny in terms of objectivity,
Hossain MR +4 more
europepmc +2 more sources
Evaluation of the effects of indomethacin tocolytic treatment on fetal heart using modified myocardial performance index (Mod-MPI) [PDF]
BMC Pregnancy and ChildbirthBackground Indomethacin is one of the most effective and widely used tocolytic agents for treating threatened preterm labor and prolonging pregnancy. Nonetheless, data on its fetal effects, particularly regarding cardiac functions, remain limited.
Barış Boza, Fırat Ersan, Verda Alpay
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Muller Journal of Medical Sciences and ResearchBackground: Preterm labor is the primary challenge in prenatal health care, leading to a high rate of mortality. As a result, in pregnant women with preterm labor, we use nitroglycerine transdermally as a tocolytic agent. The main objective of this study
Anand Tambat +2 more
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A historical narrative review through the field of tocolysis in threatened preterm birth [PDF]
European Journal of Obstetrics & Gynecology and Reproductive Biology: XPreterm birth presents a significant challenge in clinical obstetrics, requiring effective strategies to reduce associated mortality and morbidity risks.
Tijn van Winden +4 more
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Comparative effectiveness and safety of nifedipine and magnesium sulfate as treatment options for preterm birth: a systematic review and meta-analysis [PDF]
BMJ OpenObjectives Preterm birth (PTB) is a major cause of neonatal morbidity and mortality worldwide. Effective use of tocolytic agents may improve perinatal outcomes.
Jie Chen +7 more
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Synergistic effects of nifedipine and indomethacin in tocolysis: A translational study. [PDF]
Int J Gynaecol ObstetInternational Journal of Gynecology &Obstetrics, Volume 171, Issue 3, Page 1418-1420, December 2025.
Yart L, Cohen M, Martinez de Tejada B.
europepmc +2 more sources
School Performance After Maintenance Tocolysis With Nifedipine for Threatened Preterm Birth: 12-Year Follow-Up of the APOSTEL 2 Trial. [PDF]
BJOGABSTRACT Objective To evaluate school performance at 12 years of age in children prenatally exposed to maintenance tocolysis with nifedipine versus placebo. Design 12‐year follow‐up of the multicentre APOSTEL 2 trial, in which participants with threatened preterm birth between 26+0 and 32+2 weeks of gestation, who remained pregnant after initial 48‐h ...
van der Windt LI +8 more
europepmc +2 more sources