Results 151 to 160 of about 62,912 (312)

Role of COL1A1 and CD44 in Modulating JAK1/STAT3‐Mediated Autophagy for Spinal Cord Injury Recovery

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Spinal cord injury (SCI) is a severe trauma to the central nervous system that often leads to motor and sensory dysfunction in patients, severely affecting their quality of life. Autophagy plays a role in the pathological process of SCI, but the specific mechanism of autophagy in this case is unknown.
Chun‐Lei Li, Qian Zhang, Li Fang, Ling‐Yun Zhou   +3 more
wiley   +1 more source

Structure-guided selection of specificity determining positions in the human kinome [PDF]

, 2016
Background: The human kinome contains many important drug targets. It is well-known that inhibitors of protein kinases bind with very different selectivity profiles. This is also the case for inhibitors of many other protein families.
A Rausell, BY Chen, C Schalon, D Huang, D Kuhn, DH Bryant, F Milletti, F Pazos, GE Crooks, I Halperin, I Steinwart, IT Jolliffe, J Blanc, J Mok, JA Bikker, JA Capra, L Xie, L Xing, Lydia E. Kavraki, M Menke, M Moll, Mark Moll, MC Heinrich, MW Karaman, O Weigert, OC Redfern, OV Kalinina, Paul W. Finn, PW Finn, RC de Melo-Minardi, RD Finn, RK Kancha, S Chakrabarti, S Redaelli, SB Hari, SL Kinnings, T Liu, T Trowe, Y Liu   +38 more
core   +1 more source

Efficacy and safety of biologic agents and tofacitinib in moderate‐to‐severe ulcerative colitis: A systematic overview of meta‐analyses [PDF]

, 2019
Katerina Pantavou, Anneza Yiallourou, Daniele Piovani, Despo Evripidou, Silvio Danese, Laurent Peyrin‐Biroulet, Stefanos Bonovas, Georgios K. Nikolopoulos   +7 more
openalex   +1 more source

Animal Models of Bone Loss in Inflammatory Arthritis: from Cytokines in the Bench to Novel Treatments for Bone Loss in the Bedside—a Comprehensive Review [PDF]

, 2016
Throughout life, bone is continuously remodelled. Bone is formed by osteoblasts, from mesenchymal origin, while osteoclasts induce bone resorption. This process is tightly regulated. During inflammation, several growth factors and cytokines are increased
Alves, C.H. (Celso Henrique), Colin, E.M. (Edgar), Farrell, E. (Eric), Lubberts, E.W. (Erik), Vis, M. (Marijn)   +4 more
core   +1 more source

Evaluating the effects of 5‐aminosalicylic acid on tofacitinib treatment in ulcerative colitis

Journal of Gastroenterology and Hepatology
Tofacitinib and aminosalicylic acid (5‐ASA) are commonly used to treat ulcerative colitis (UC). However, evidence on the effect of concomitant 5‐ASA use in patients receiving tofacitinib is limited.
Y. Nishida, S. Hosomi, Koji Fujimoto, Yumie Kobayashi, Rieko Nakata, Hirotsugu Maruyama, Masaki Ominami, Yuji Nadatani, S. Fukunaga, K. Otani, F. Tanaka, Y. Fujiwara   +11 more
semanticscholar   +1 more source

COVID-19 Vaccine-Induced Antibody Responses are Impaired in IBD Patients Treated with Infliximab or Tofacitinib, but not Thiopurines, Ustekinumab or Vedolizumab

, 2021
James L. Alexander, Nicholas A. Kennedy, Hajir Ibraheim, Sulak Anandabaskaran, Aamir Saifuddin, Rocio Castro Seoane, Zhigang Liu, Rachel Nice, Claire Bewshea, Andrea D’Mello, Laura Constable, Gareth Jones, Sharmili Balarajah, Francesca Fiorentino, Shaji Sebastian, Peter M. Irving, Lucy Hicks, Horace R. Williams, Alexandra Kent, Rachel Linger, Rebecca King, Miles Parkes, Klaartje Kok, Kamal Patel, Julian Teare, Daniel M. Altmann, Rosemary J. Boyton, James Goodhand, Ailsa Hart, Charlie W. Lees, Tariq Ahmad, Nick Powell, The VIP Study Investigators   +32 more
openalex   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Letter: thromboembolic and cardiovascular events with tofacitinib in ulcerative colitis—two cases in real world clinical practice [PDF]

, 2020
Paulo Gustavo Kotze, Fábio Vieira Teixeira, Adérson Omar Mourão Cintra Damião   +2 more
openalex   +1 more source

AB0383 COMPARISON OF EFFICACY AND SAFETY IN JAK INHIBITOR DUE TO A DIFFERENCE OF SELECTIVITY – TOFACITINIB vs. BARICITINIB – [PDF]

, 2022
Ichiro Yoshii, Naoya Sawada, Tatsumi Chijiwa   +2 more
openalex   +1 more source

Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases

Rare Metals, EarlyView.
ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan, Shengjie Xue, Junyi Yin, Shaolei Wang, Yunlei Zhou, Jieyue Liao   +5 more
wiley   +1 more source