Results 1 to 10 of about 4,930 (173)

Tofo gotoso de pie como simulador de neuroma de Morton. [Feet gouty tophus as a Morton’s].

Revista de la Asociación Argentina de Ortopedia y Traumatología, 2016
Presentamos este caso para resaltar la importancia de la identificación de los tofos gotosos en localizaciones menos clásicas, incluso en pacientes sin crisis de artritis previas, uso de terapia hipouricemiante o factores de riesgo, ya que los tofos gotosos auriculares pueden ser la primera manifestación de la gota, a pesar de que se ha considerado que
Maximiliano Seletti, Gaston Slullitel, Juan Pablo Calvi, Gustavo Pinton, Carla Bartolucci, Valeria Lopez   +5 more
doaj   +12 more sources

Sarcoma pleomórfico indiferenciado de alto grado/ fibrohistiocitoma maligno asociado a tofo gotoso. presentación de un caso

Revista de la Facultad de Ciencias Médicas de Córdoba, 2012
Antecedentes: La gota es una enfermedad metabólica por depósito de cristales de ácido úrico, que compromete articulaciones y tejidos blandos tanto en sus etapas agudas como crónicas.
Susana Szlabi, Jorge O. Flores, Ana L. de Diller, Marta B. Cabrera   +3 more
doaj   +4 more sources

Tofogliflozin ameliorates cardiotoxin induced skeletal muscle injury and fibrosis in obesity [PDF]

Scientific Reports
Obesity impairs muscle function through effects on lipid metabolism, systemic inflammation, and insulin resistance, leading to muscle loss and reduced regeneration.
Muhammad Bilal, Nguyen Quynh Phuong, Tomonobu Kado, Jianhui Liu, Le Duc Anh, Sana Khalid, Muhammad Rahil Aslam, Memoona, Ayumi Nishimura, Yoshiko Igarashi, Yoshiyuki Watanabe, Waseem Abbas, Maki Yokoyama, Yasuhiro Onogi, Kenichi Hirabayashi, Seiji Yamamoto, Kunimasa Yagi, Marsel Lino, Isao Usui, Masaru Kato, Shiho Fujisaka, Allah Nawaz, Kazuyuki Tobe   +22 more
doaj   +3 more sources

Effects of Progranulin Deficiency on Inflammation and Fibrosis in the Kidneys and Liver of Diabetic Mice Fed a High-Fat Diet [PDF]

Endocrinology and Metabolism
Background Progranulin (PGRN) is an important regulator of inflammation, insulin resistance, and autophagy. However, the effects of PGRN deficiency on these processes in the kidneys and liver in diabetes remain unclear.
Hiroko Sakuma, Maki Murakoshi, Shinji Hagiwara, Terumi Shibata, Yusuke Suzuki, Tomohito Gohda   +5 more
doaj   +3 more sources

Paraplegia aguda por compressão da medula espinhal torácica causada por tofo gotoso Acute paraplegia resulting from spinal cord compression by tophaceous gout [PDF]

Revista Brasileira de Reumatologia, 2007
O acometimento axial pela gota é um evento raro, e o envolvimento da coluna torácica foi descrito em apenas 17 casos na literatura. Apresentamos um caso de paciente do sexo masculino de 48 anos com história de gota, sob tratamento irregular com ...
Eduardo Massato Hasegawa, Claudia Goldeinstein-Schainberg, Ricardo Fuller   +2 more
doaj   +6 more sources

Tofo gotoso en dorso nasal: reporte de caso

Revista Científica, 2022
La gota es el trastorno del metabolismo de las purinas que se caracteriza por acumulación de ácido úrico por aumento de su producción o por disminución de su excreción. Con el paso del tiempo, el exceso de urato monosódico permite que se deposite en diferentes tejidos del organismo; siendo particularmente infrecuente la presentación de tofos a nivel ...
Karen Flores Mena, Ricardo García Santamaría   +1 more
openaire   +2 more sources

Effects of Tofogliflozin and Anagliptin Alone or in Combination on Glucose Metabolism and Atherosclerosis-Related Markers in Patients with Type 2 Diabetes Mellitus [PDF]

Clinical Pharmacology: Advances and Applications, 2023
Shosaku Nomura,1 Akira Shouzu,2 Takehito Taniura,3 Yoshinori Okuda,4 Seitaro Omoto,5 Masahiko Suzuki,6 Tomoki Ito,7 Nagaoki Toyoda8 1Center of Thrombosis and Hemostasis, Kansai Medical University Medical Center, Moriguchi, Japan; 2Division of Diabetes ...
Nomura S, Shouzu A, Taniura T, Okuda Y, Omoto S, Suzuki M, Ito T, Toyoda N   +7 more
doaj   +2 more sources

Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis [PDF]

Cells, 2022
Ballooning degeneration of hepatocytes is a major distinguishing histological feature of non-alcoholic steatosis (NASH) progression that can lead to cirrhosis and hepatocellular carcinoma (HCC).
Kentaro Murakami, Yusuke Sasaki, Masato Asahiyama, Wataru Yano, Toshiaki Takizawa, Wakana Kamiya, Yoshihiro Matsumura, Motonobu Anai, Tsuyoshi Osawa, Jean-Charles Fruchart, Jamila Fruchart-Najib, Hiroyuki Aburatani, Juro Sakai, Tatsuhiko Kodama, Toshiya Tanaka   +14 more
doaj   +2 more sources

Tofogliflozin attenuates liver steatosis and fibrosis in non-diabetic non-alcoholic steatohepatitis mice [PDF]

BMC Gastroenterology
Background Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease with increasing global prevalence. Although diabetes is a major factor in NAFLD progression, up to 75% of the patients with NAFLD do not have diabetes ...
Yoshinori Ozono, Hiroshi Kawakami, Hiroshi Hatada, Naomi Uchiyama, Souichiro Ogawa, Keisuke Uchida, Hotaka Tamura, Yuri Komaki, Kenichi Nakamura, Hisayoshi Iwakiri, Satoru Hasuike, Kenji Nagata   +11 more
doaj   +2 more sources

A Mozambican marine protected area provides important habitat for vulnerable pelagic sharks [PDF]

Scientific Reports, 2023
Pelagic sharks play key roles in marine ecosystems, but are increasingly threatened by human extraction, habitat degradation and mismanagement. We investigated the use of protected and unprotected coastal habitats by bull (Carcharhinus leucas) and ...
Calum J. G. Murie, Mario Lebrato, Andrew Lawrence, James Brown, Livia Gavard, Karen R. Bowles, Mauro G. Jije, Matt Dicken, Simon P. Oliver   +8 more
doaj   +2 more sources