Results 151 to 160 of about 16,123 (208)
Cytochrome P 450 2C9 phenotyping using low-dose tolbutamide
European Journal of Clinical Pharmacology, 2004 Objectives. The hypoglycaemic drug tolbutamide is used for assessment of CYP2C9 activity in vivo. However, therapeutically active doses of 500 mg bear the risk of hypoglycaemia, and a tolbutamide-derived parameter based on a single plasma or urine ...
Uwe Fuhr +2 more
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Cytosolic ADP enhances the sensitivity to tolbutamide of ATP-dependent K+ channels from pancreatic B-cells [PDF]
FEBS Letters, 1988 The effects of intracellular purine nucleotides on tolbutamide-induced block of ATP-dependent K+ channels from mouse pancreatic B-cells were studied using the patch-clamp technique.
G Trube, B J Zünkler, U Panten
exaly +2 more sources
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Annals of Internal Medicine, 1971
Excerpt To the editor: Dr. Schwartz's article on the tolbutamide controversy (ANNALS75:303-306, 1971) is revealing in its presentation of the moral dilemmas that face the physician-researcher.
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Excerpt To the editor: Dr. Schwartz's article on the tolbutamide controversy (ANNALS75:303-306, 1971) is revealing in its presentation of the moral dilemmas that face the physician-researcher.
openaire +2 more sources
Protracted tolbutamide hypoglycemia
The American Journal of Medicine, 1963Abstract Three cases of prolonged tolbutamide-induced hypoglycemia are reported. Four additional cases, with hypoglycemia greater than twenty-four hours duration, are collected from the literature. The high mortality rate may result, in part, from clinical unfamiliarity with this complication of tolbutamide administration.
P, CUSHMAN +3 more
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Tolbutamide in the Treatment of Parkinsonism
JAMA, 1961A RECENT preliminary report on the use of tolbutamide in paralysis agitans stated that 11 of 15 patients with this disorder showed considerable decrease in rigidity, tremor, or both, after the administration of this hypoglycemic agent. 1 Improvement of mask-like facies and speech was also noted in several patients. The authors found that the effect was
G L, HELLER, R N, DEJONG, K R, MAGEE
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Hepatotoxicity of Tolbutamide in Dogs
Journal of the American Veterinary Medical Association, 1970SUMMARY Three normal dogs were given sodium tolbutamide in daily oral doses of 30, 65, or 130 mg./kg.; a fourth served as the control. By day 37, the 2 that were given the larger doses became debilitated and had to be killed. They had developed hypoglycemia, degranulation of pancreatic beta cells, reduction in extractable pancreatic insulin, and ...
R B, Wilson, W D, Wilson
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Potentiation of Tolbutamide by Dicumarol
Annals of Internal Medicine, 1967Excerpt The "Drug Explosion" has bred a litter of dilemmas. Simpler was life for the patient of yesteryear who was given a sugarcoated pill.
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