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Effect of Cytochrome P450 2C9 genetic polymorphism on agomelatine metabolism <i>in vitro</i>. [PDF]
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Pharmacogenetics of Tolbutamide Metabolism in Humans
Diabetes, 1978This study was designed to focus on the genetic control of tolbutamide disposition in humans and to provide insight into the potential for high accrued blood levels in individuals receiving fixed dosage regimens. Tolbutamide was administered intravenously to 42 nondiabetic subjects, eight of their relatives, and to five sets of twins.
P L Poffenbarger
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Annals of Internal Medicine, 1971
Excerpt To the editor: Dr. Schwartz's article on the tolbutamide controversy (ANNALS75:303-306, 1971) is revealing in its presentation of the moral dilemmas that face the physician-researcher.
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Excerpt To the editor: Dr. Schwartz's article on the tolbutamide controversy (ANNALS75:303-306, 1971) is revealing in its presentation of the moral dilemmas that face the physician-researcher.
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Hepatotoxicity of Tolbutamide in Dogs
Journal of the American Veterinary Medical Association, 1970SUMMARY Three normal dogs were given sodium tolbutamide in daily oral doses of 30, 65, or 130 mg./kg.; a fourth served as the control. By day 37, the 2 that were given the larger doses became debilitated and had to be killed. They had developed hypoglycemia, degranulation of pancreatic beta cells, reduction in extractable pancreatic insulin, and ...
R B, Wilson, W D, Wilson
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Tolbutamide in the Treatment of Parkinsonism
JAMA, 1961A RECENT preliminary report on the use of tolbutamide in paralysis agitans stated that 11 of 15 patients with this disorder showed considerable decrease in rigidity, tremor, or both, after the administration of this hypoglycemic agent. 1 Improvement of mask-like facies and speech was also noted in several patients. The authors found that the effect was
G L, HELLER, R N, DEJONG, K R, MAGEE
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Protracted tolbutamide hypoglycemia
The American Journal of Medicine, 1963Abstract Three cases of prolonged tolbutamide-induced hypoglycemia are reported. Four additional cases, with hypoglycemia greater than twenty-four hours duration, are collected from the literature. The high mortality rate may result, in part, from clinical unfamiliarity with this complication of tolbutamide administration.
P, CUSHMAN +3 more
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