Results 81 to 90 of about 7,251 (175)
mSystemsArtemisinin (ARS) displayed bactericidal activity against Vibrio cholerae. To assess the mechanistic details of its antibacterial action, we have isolated V.
In-Young Chung +3 more
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Frontiers in Microbiology, 2018 The MacB ABC transporter forms a tripartite efflux pump with the MacA adaptor protein and TolC outer membrane exit duct to expel antibiotics and export virulence factors from Gram-negative bacteria.
Nicholas P. Greene +3 more
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Virulence genes in Moraxella spp. isolates from infectious bovine keratoconjunctivitis cases
Journal of Infection in Developing Countries, 2015 Introduction: Infectious bovine keratoconjunctivitis (IBK) is an important ocular disease which affects cattle worldwide. To advance towards IBK effective prevention and treatment strategies, it is important to define the distribution and genetic ...
Vanessa Sosa +3 more
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Sequential Mechanism of Assembly of Multidrug Efflux Pump AcrAB-TolC
Chemistry & Biology, 2011 Multidrug efflux pumps adversely affect both the clinical effectiveness of existing antibiotics and the discovery process to find new ones. In this study, we reconstituted and characterized by surface plasmon resonance the assembly of AcrAB-TolC, the archetypal multidrug efflux pump from Escherichia coli.
Tikhonova, Elena B. +2 more
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Microbiology SpectrumWhole-genome sequencing of a clinical tigecycline non-susceptible Klebsiella pneumoniae strain reveals a novel T188A mutation in AcrA, raising awareness on its role in tigecycline resistance.
Yingchao Xu +6 more
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Medical Journal of BabylonBackground: Opportunistic pathogen Proteus mirabilis is resistant to multiple antibiotic classes and frequently causes infections. A significant threat to global public health exists in the emergence and spread of novel antimicrobial resistance genes ...
Hawraa Wahab Al-Kaim +1 more
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Zhongguo shiyan zhenduanxue, 2014 目的研究临床分离的阴沟肠杆菌AcrAB-TolC外排系统基因的携带情况及其与抗菌药物耐药性的关系。方法对临床分离的141株阴沟肠杆菌用MicroScanWalkAway40全自动细菌分析仪进行鉴定和药敏试验;聚合酶链式反应（PCR）检测AcrAB-TolC外排系统acrA,acrB,tolC和acrR 4种基因在阴沟肠杆菌中的分布,并对PCR产物进行纯化、克隆、测序。结果 acrA,acrB,tolC和acrR 4种基因在141株阴沟肠杆菌中的检出率分别为98.5%、51.06%、82.27%、78 ...
温见翔, 陈娟, 杨虹
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PLoS ONE, 2014 Escherichia coli produces the iron-chelating compound enterobactin to enable growth under iron-limiting conditions. After biosynthesis, enterobactin is released from the cell. However, the enterobactin export system is not fully understood.
Tsukasa Horiyama, Kunihiko Nishino
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npj Antimicrobials and ResistanceSince its discovery nearly 60 years ago, TolC has been associated with various cellular functions in Escherichia coli, including the efflux of environmental stressors and virulence factors.
Mallory Wright +3 more
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Scientific ReportsWhile antibiotic resistance poses a threat from both Gram-positive bacteria (GPB) and Gram-negative bacteria (GNB), GNB pose a more imminent public health hazard globally. GNB are a threat to growing antibiotic resistance because of the complex makeup of
Brooke L. Smith +2 more
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