Results 71 to 80 of about 7,251 (175)
Frontiers in Cellular and Infection Microbiology, 2018 Our previous study showed that the inactivation of the efflux pump TolC could abolish biofilm formation and curli production of extraintestinal pathogenic Escherichia coli (ExPEC) strain PPECC42 under hyper-osmotic conditions.
Binyou Li +8 more
doaj +1 more source
Controlled Delivery and Light‐Induced Release of Magic Spot Nucleotides in Escherichia coli
Angewandte Chemie International Edition, Volume 65, Issue 15, 6 April 2026.We synthesized photocaged, clickable and isotope‐labeled “magic spot” Nucleotides and delivered them into Escherichia coli comparing different approaches. Light‐controlled release inside living cells enabled tracking of their conversion from pppGpp to ppGpp by capillary electrophoresis mass spectrometry and revealed their impact on the growth rate of a
Christoph Popp +12 more
wiley +1 more source
MicrobiologyOpen, Volume 15, Issue 2, April 2026.Retail meat–derived E. coli frequently harbored multidrug‑resistance phenotypes, diverse virulence determinants, and plasmid‑encoded resistance genes with high conjugative potential. Results indicate meat and poultry as underrecognized reservoirs facilitating dissemination of antimicrobial resistance and pathogenic lineages, with imported products ...
Saehah Yi +7 more
wiley +1 more source
Gating at Both Ends and Breathing in the Middle: Conformational Dynamics of TolC [PDF]
Biophysical Journal, 2008 Drug extrusion via efflux through a tripartite complex (an inner membrane pump, an outer membrane protein, and a periplasmic protein) is a widely used mechanism in Gram-negative bacteria. The outer membrane protein (TolC in Escherichia coli; OprM in Pseudomonas aeruginosa) forms a tunnel-like pore through the periplasmic space and the outer membrane ...
Vaccaro, L, Scott, K, Sansom, MS
openaire +2 more sources
MedComm, Volume 7, Issue 4, April 2026.This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva +3 more
wiley +1 more source
Pimozide Inhibits the AcrAB-TolC Efflux Pump in Escherichia coli [PDF]
The Open Microbiology Journal, 2013 Efflux pump inhibitors (EPIs) are attractive compounds to reverse multidrug-resistance in clinically relevant bacterial pathogens. In this study we tested the ability of the neuroleptic drug pimozide to inhibit the Escherichia coli AcrAB-TolC efflux pump, whose overproduction confers resistance to various antimicrobial agents.
Bohnert, Jürgen A +2 more
openaire +3 more sources
ChemMedChem, Volume 21, Issue 5, 13 March 2026.Within this review we provide an overview of the social relevance of quaternary ammonium surfactants, different classes of these agents, their interaction mechanism with cellular membranes, structure activity relation, bacterial resistance toward these systems and new approaches to guarantee their long‐term efficiency.
Natalie Hanheiser +3 more
wiley +1 more source
Ecology and Evolution, Volume 16, Issue 3, March 2026.Emerging infectious diseases increasingly threaten giant pandas and cohabiting species. This review analyzes pathogen transmission risks from domestic animals, wildlife, and vectors and proposes an integrated genomic surveillance framework for early warning and biodiversity conservation.
Xiaoli Sun +10 more
wiley +1 more source
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 2, March 2026.ABSTRACT Essential oils (EOs) exhibit antimicrobial activity against foodborne pathogens due to their chemical composition. This review investigates the mechanisms of action of EOs at subinhibitory concentrations against Salmonella strains. Even at subinhibitory concentrations, EOs induce cellular stress and modulate bacterial metabolism. EOs interfere
Carolina Ramos +5 more
wiley +1 more source
Reviews in Aquaculture, Volume 18, Issue 2, March 2026.This scoping review with textual analysis maps antimicrobial resistance in Salmonella across aquaculture, seafood, and related aquatic environments. Across 93 studies, recurrent MDR patterns suggest sentinel serotypes (S. Typhimurium, S. Newport) and a minimal antimicrobial susceptibility testing (AST) panel to guide matrix‐stratified One Health ...
Cristiane Coimbra de Paula +8 more
wiley +1 more source