Results 51 to 60 of about 7,251 (175)

Drug Efflux Pump Inhibitors: A Promising Approach to Counter Multidrug Resistance in Gram-Negative Pathogens by Targeting AcrB Protein from AcrAB-TolC Multidrug Efflux Pump from Escherichia coli

Biology, 2022
Infections caused by multidrug resistance (MDR) of Gram-negative bacteria have become one of the most severe public health problems worldwide. The main mechanism that confers MDR to bacteria is drug efflux pumps, as they expel a wide range of compounds ...
Rawaf Alenazy
doaj   +1 more source

Crucial Role of Legionella pneumophila TolC in the Inhibition of Cellular Trafficking in the Protistan Host Paramecium tetraurelia

Frontiers in Microbiology, 2018
Legionella pneumophila is a facultative intracellular Gram-negative bacterium, which is a major causative agent of Legionnaires’ disease. In the environment, this bacterium survives in free-living protists such as amoebae and Tetrahymena. The association
Takashi Nishida, Naho Hara, Kenta Watanabe, Takashi Shimizu, Masahiro Fujishima, Masahiro Fujishima, Masahisa Watarai   +6 more
doaj   +1 more source

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson, Cerissa C. van Walstijn, Vladyslav Lysenko, Marta A. Wilbrink, David Alencar Araripe, Jeroen M. Punt, Mario van der Stelt, Willem Jespers, Paolo Innocenti, Nathaniel I. Martin   +9 more
wiley   +1 more source

Escherichia coli Exports Cyclic AMP via TolC [PDF]

Journal of Bacteriology, 2011
ABSTRACT In Escherichia coli more than 180 genes are regulated by the cyclic AMP (cAMP)-cAMP receptor protein (CRP) complex. However, more than 90% of cAMP that is made by intracellular adenylyl cyclases is found in the culture medium. How is cAMP exported from E. coli ? In a
Klaus, Hantke, Karin, Winkler, Joachim E, Schultz   +2 more
openaire   +2 more sources

VP3 Phage Combined with High Salt Promotes the Lysis of Biofilm-Associated Vibrio cholerae

Viruses, 2023
Cholera, caused by pathogenic Vibrio cholerae, poses a significant public health risk through water and food transmission. Biofilm-associated V. cholerae plays a crucial role in seasonal cholera outbreaks as both a reservoir in aquatic environments and a
Xu Li, Xiaorui Li, Huayao Zhang, Biao Kan, Fenxia Fan   +4 more
doaj   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Production of Chicken Egg Yolk Immuno-globulin (IgY) against Recombinant TolC Pro-tein From Shigella flexneri Bacteria [PDF]

Iranian South Medical Journal
Background: Growing antibiotic resistance is a global concern for the treatment of shigellosis. The development of efflux pumps such as the AcrAB-TolC pump has increased antibiotic resistance in Shigella flexneri strains.
Hossein Samiei-Abianeh, Shahram Nazarian, Amir Resaei, Nahal Hadi, Kosar Kayvan shokooh   +4 more
doaj  

Francisella tularensis disrupts TLR2-MYD88-p38 signaling early during infection to delay apoptosis of macrophages and promote virulence in the host

mBio, 2023
Francisella tularensis is a zoonotic pathogen and the causative agent of tularemia. F. tularensis replicates to high levels within the cytosol of macrophages and other host cells while subverting the host response to infection. Critical to the success of
P. Todd Benziger, Erik J. Kopping, Patrick A. McLaughlin, David G. Thanassi   +3 more
doaj   +1 more source

Assessment of Antimicrobial Activity, Membrane Integrity, and Oxidative Stress of Green Synthesized Silver Nanoparticles: In Vitro and Molecular Docking Studies

ChemistryOpen, Volume 15, Issue 6, June 2026.
Green Synthesized Silver Nanoparticles: In Vitro and Molecular Docking Studies. Silver nanoparticles were synthesized using Acacia karroo aqueous leaves extract for the first time, as evidenced by a characteristic UV–Vis absorption peak at 424 nm. Spherical morphologies were observed using transmission electron microscopy (TEM) and scanning electron ...
Sarra Sebti, Badra Barhouchi, Samir Meskaldji, Haroun Houicha, Eyup Bagci, Hamdi Bendif, Walid Elfalleh, Stefania Garzoli   +7 more
wiley   +1 more source

The Biofilm Inhibitor Carolacton Enters Gram-Negative Cells: Studies Using a TolC-Deficient Strain of Escherichia coli

mSphere, 2017
The myxobacterial secondary metabolite carolacton inhibits growth of Streptococcus pneumoniae and kills biofilm cells of the caries- and endocarditis-associated pathogen Streptococcus mutans at nanomolar concentrations.
Jannik Donner, Michael Reck, Boyke Bunk, Michael Jarek, Constantin Benjamin App, Jan P. Meier-Kolthoff, Jörg Overmann, Rolf Müller, Andreas Kirschning, Irene Wagner-Döbler   +9 more
doaj   +1 more source