Results 41 to 50 of about 7,251 (175)

TOLC-DERIVED PAN-RICKETTSIAL PEPTIDE VACCINES ELICIT B- AND T- CELL IMMUNE RESPONSES

International Journal of Infectious Diseases, 2023
Intro: The putative TolC-derived antigenic epitope may trigger an effective immune response and prove to be a novel vaccine that protects against all rickettsial infections.
S. Sankar
doaj   +1 more source

Pseudoatomic Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Reveals the Intermeshing Cogwheel-like Interaction between AcrA and TolC [PDF]

Structure, 2016
The resistance-nodulation-division type tripartite pump AcrAB-TolC and its homologs are responsible for multidrug resistance in Gram-negative bacteria by expelling a wide variety of toxic substrates. The three essential components, AcrA, AcrB, and TolC, must function in concert with each respective binding partner within the complex.
Jeong, Hyeongseop, Kim, Jin-Sik, Song, Saemee, Shigematsu, Hideki, Yokoyama, Takeshi, Hyun, Jaekyung, Ha, Nam-Chul   +6 more
openaire   +2 more sources

TolC facilitates the intracellular survival and immunomodulation of Salmonella Typhi in human host cells

Virulence
Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a systemic infection that affects millions of people worldwide. S. Typhi can invade and survive within host cells, such as intestinal epithelial cells and macrophages, by modulating their
Ashraf Hussain, Eugene Boon Beng Ong, Prabha Balaram, Asma Ismail, Phua Kia Kien   +4 more
doaj   +1 more source

Scaffold size-dependent effect on the enhanced uptake of antibiotics and other compounds by Escherichia coli and Pseudomonas aeruginosa

Scientific Reports, 2022
The outer membrane of Gram-negative bacteria functions as an impermeable barrier to foreign compounds. Thus, modulating membrane transport can contribute to improving susceptibility to antibiotics and efficiency of bioproduction reactions. In this study,
Kyosuke Yamamoto, Nao Yamamoto, Shotaro Ayukawa, Yoshiaki Yasutake, Koji Ishiya, Nobutaka Nakashima   +5 more
doaj   +1 more source

TolC is Required for Pathogenicity of Xylella fastidiosa in Vitis vinifera Grapevines

Molecular Plant-Microbe Interactions, 2007
Xylella fastidiosa infects a wide range of hosts and causes serious diseases on some of them. The complete genomic sequences of both a citrus variegated chlorosis (CVC) and a Pierce's disease (PD) strain revealed two type I protein secretion plus two ...
Joseph D. Reddy, Stephanie L. Reddy, Don L. Hopkins, Dean W. Gabriel   +3 more
doaj   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Protoporphyrin (PPIX) efflux by the MacAB‐TolC pump in Escherichia coli [PDF]

MicrobiologyOpen, 2014
In most organisms, heme biosynthesis is strictly controlled so as to avoid heme and heme precursor accumulation, which is toxic. Escherichia coli regulates heme biosynthesis by a feedback loop involving heme-induced proteolytic cleavage of HemA, glutamyl-tRNA reductase, which is the first enzyme in the heme biosynthetic pathway.
Turlin, Evelyne, Heuck, Gesine, Simões Brandão, Maria Inês, Szili, Noémie, Mellin, J. R., Lange, Norbert, Wandersman, Cécile   +6 more
openaire   +3 more sources

Reducing the Periplasmic Glutathione Content Makes Escherichia coli Resistant to Trimethoprim and Other Antimicrobial Drugs

Microbiology Spectrum, 2021
Although glutathione (GSH) has been shown to influence the antimicrobial effects of many kinds of antibiotics, little is known about its role in relation to trimethoprim (TMP), a widely used antifolate. In this study, several genes related to glutathione
Yajing Song, Zhen Zhou, Jing Gu, Junmei Yang, Jiaoyu Deng   +4 more
doaj   +1 more source

Seasonal Restructuring of Microbial Communities and Resistomes in the Shitalakshya River, Bangladesh Revealed by Shotgun Metagenomics

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Dry‐season pollutant concentration drives microbial restructuring in Bangladesh's Shitalakshya River, shifting communities from Myroides to stress‐tolerant genera while enriching metal resistance genes and efflux pumps, revealing non‐antibiotic co‐selection as a key driver of antimicrobial resistance in urban waters.
Muhammad Ehteshamul Haque, Md. Shaminur Rahman, Munawar Sultana, Anowara Begum   +3 more
wiley   +1 more source

Accumulation of Histidine Reduce the Susceptibility of Vibrio splendidus Persister Cells to Tetracycline

Environmental Microbiology Reports, Volume 18, Issue 4, August 2026.
Histidine accumulation promotes tetracycline‐induced persister formation in V. splendidus. It enhances membrane potential and upregulating the efflux pump gene, thereby reducing antibiotic susceptibility. ABSTRACT Vibrio splendidus is an opportunistic pathogen widely distributed in marine environments, animal tissues and seabed sediments. It can infect
Yanan Li, Xinnan Pan, Jiayao Chen, Hong Ding, Yina Shao   +4 more
wiley   +1 more source