Results 101 to 110 of about 3,006,416 (351)

Lower Bounds for Tolerant Junta and Unateness Testing via Rejection Sampling of Graphs [PDF]

arXiv, 2018
We introduce a new model for testing graph properties which we call the \emph{rejection sampling model}. We show that testing bipartiteness of $n$-nodes graphs using rejection sampling queries requires complexity $\widetilde{\Omega}(n^2)$. Via reductions from the rejection sampling model, we give three new lower bounds for tolerant testing of Boolean ...
arxiv  

The Immune Tolerance Network: tolerance at the crossroads [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001
Immune tolerance therapies are designed to reprogramme immune cells in a highly specific fashion in order to eliminate pathogenic responses but preserve normal immune function. A concept that has tantalized immunologists for decades, tolerogenic therapies would replace current lifelong immunosuppressive regimens and their often debilitating side ...
Jeffrey Matthe, Jeffrey A. Bluestone
openaire   +3 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Co-evolutionnary network approach to cultural dynamics controlled by intolerance

, 2011
Starting from Axelrod's model of cultural dissemination, we introduce a rewiring probability, enabling agents to cut the links with their unfriendly neighbors if their cultural similarity is below a tolerance parameter.
Carlos Gracia-Lázaro, Fernando Quijandría, J. C. González-Avella, J. M. Epstein, J. Marro, Laura Hernández, Luis Mario Floría, R. Axelrod, T. C. Schelling, Yamir Moreno   +9 more
core   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Pyrosequencing Approach for SNP Genotyping in Plants Using a M13 Biotinylated Primer

Bio-Protocol, 2015
Single Nucleotide Polymorphisms (SNPs), which constitute single base-pair variations in the DNA sequence, are the most abundant molecular markers in plant and animal genomes.
Cristina Silvar, Dragan Perovic, Anna Casas, Ernesto Igartua, Frank Ordon   +4 more
doaj   +1 more source

Error-Tolerating Bell Inequalities via Graph States [PDF]

arXiv, 2009
We investigate the Bell inequalities derived from the graph states with violations detectable even with the presence of noises, which generalizes the idea of error-correcting Bell inequalities [Phys. Rev. Lett. 101, 080501 (2008)]. Firstly we construct a family of valid Bell inequalities tolerating arbitrary $t$-qubit errors involving $3(t+1)$ qubits ...
arxiv  

Relating threshold tolerance graphs to other graph classes [PDF]

, 2014
A graph G=(V, E) is a threshold tolerance if it is possible to associate weights and tolerances with each node of G so that two nodes are adjacent exactly when the sum of their weights exceeds either one of their tolerances.
CALAMONERI, Tiziana, SINAIMERI, BLERINA
core   +1 more source