Results 121 to 130 of about 3,006,416 (351)
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Application-layer Fault-Tolerance Protocols [PDF]
arXiv, 2016 The central topic of this book is application-level fault-tolerance, that is the methods, architectures, and tools that allow to express a fault-tolerant system in the application software of our computers. Application-level fault-tolerance is a sub-class of software fault-tolerance that focuses on the problems of expressing the problems and solutions ...
arxiv
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Every Action in Every Code is Fault Tolerant: Fault Tolerance Quantum Computation in Quotient Algebra Partition [PDF]
arXiv, 2019 In the framework quotient algebra partition, a general methodology is introduced to construct fault tolerant encodes for an arbitrary action in an error-correcting code.
arxiv
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
On the Conceptual Insufficiency of Toleration and the Quest for a Superseding Concept [PDF]
, 2019 The concept of toleration occupies an important position in contemporary societal debates. I will analyse the concept by considering the apparent inconsistency between what I regard as the genuine meaning of the concept of toleration ...
Klix, Nikolai
core +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
THE EFFECT OF INTRAVENOUS INFUSION OF THROMBOPLASTIN ON “HEPARIN TOLERANCE” 1 [PDF]
, 1951 Robert C. Hartmann +4 more
openalex +1 more source
Fault-Tolerant Postselected Quantum Computation: Threshold Analysis [PDF]
arXiv, 2004 The schemes for fault-tolerant postselected quantum computation given in [Knill, Fault-Tolerant Postselected Quantum Computation: Schemes, http://arxiv.org/abs/quant-ph/0402171] are analyzed to determine their error-tolerance. The analysis is based on computer-assisted heuristics.
arxiv
CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability
Molecular Oncology, EarlyView.Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki +2 more
wiley +1 more source