Results 131 to 140 of about 1,715,473 (311)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Combined Time and Information Redundancy for SEU-Tolerance in Energy-Efficient Real-Time Systems

, 2006
Recently the trade-off between energy consumption and fault-tolerance in real-time systems has been highlighted. These works have focused on dynamic voltage scaling (DVS) to reduce dynamic energy dissipation and on time redundancy to achieve transient ...
Rosinger, Paul, Ejlali, Ali, Schmitz, Marcus, Miremadi, Seyed G., Al-Hashimi, Bashir M.   +4 more
core   +1 more source

PEG treatment is unsuitable to study root related traits as it alters root anatomy in barley (Hordeum vulgare L.)

BMC Plant Biology
Background The frequency and severity of abiotic stress events, especially drought, are increasing due to climate change. The plant root is the most important organ for water uptake and the first to be affected by water limitation.
Veronic Töpfer, Michael Melzer, Rod J. Snowdon, Andreas Stahl, Andrea Matros, Gwendolin Wehner   +5 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Techniques to minimize circuitry and improve efficiency for defect tolerance [PDF]

, 2013
textAs technology continues to scale to smaller geometries and newer dimensions (3-D), with increasingly complex manufacturing processes, the ability to reliably manufacture 100% defect-free circuitry becomes a significant challenge.
Rab, Muhammad Tauseef
core  

Organic fertilizer and microbial agents increase soil quality and maize yield on coastal saline-alkali land

Soil and Water Research
To evaluate the effects of organic fertilizer and microbial agents on soil water and salt distribution, microorganisms, and crop yield on coastal saline-alkaline land, eight treatments were established, i.e., two maize varieties (Dajing Jiu 26 (J) and ...
Zengjiao Wang, Yin Zhang, Deheng Zhang, Shenghao Zhang, Hongxiang Zhao, Zhen Liu, Geng Li, Tangyuan Ning   +7 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Immune tolerance in hemophilia with factor VIII inhibitors: predictors of success

Haematologica, 2001
BACKGROUND AND OBJECTIVES: Long term administration of high doses of factor VIII (FVIII) was shown to eliminate alloantibodies to FVIII (FVIII inhibitors). This procedure is widely referred to as immune tolerance (IT).
G Mariani, B Kroner, Immune Tolerance Study Group (ITSG)   +2 more
doaj  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source