The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
Islam and tolerance: an overview of some discourses on tolerance and intolerance of Islam
, 2008 It should be pointed out that on the issue of Islam and Tolerance, there are countless works, papers and articles that have been written on it. However, what this paper intends to do is to simply highlight the trends of thought on the issue as may be ...
Muhamad Shukri, Abdul Salam
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IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
DeepLabCut-based automated system reveals diverse temperature tolerance among medaka strains and related Oryzias species. [PDF]
Sci RepMatsuo Y +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
No evidence of higher peak heat tolerance in the afternoon or with opportunity for thermal behaviour during low-intensity work in uncompensable heat. [PDF]
Exp PhysiolStothers T +5 more
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
DEPREDATION CLAIM BEHAVIOR AND TOLERANCE OF WILDLIFE IN WYOMING [PDF]
Wyoming Game and Fish Department depredation payments were established to increase landowner tolerance toward, and this the supply of, certain types of wildlife.
Van Tassell, Larry W. +2 more
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Quantifying Waterlogging Tolerance and Recovery Capacity of Jute Genotypes During Early Growth Stage Through Agronomic Trait-Based Comprehensive Evaluation Value. [PDF]
Scientifica (Cairo)Nizam R +6 more
europepmc +1 more source