Results 321 to 330 of about 3,006,416 (351)
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Rapid tolerance and cross-tolerance as predictors of chronic tolerance and cross-tolerance
Pharmacology Biochemistry and Behavior, 1992Hypothermia and motor impairment (tilt-plane) tests were used to assess the phenomenon of rapid tolerance to ethanol and cross-tolerance to various alcohols, benzodiazepines, and barbiturates that differ in lipid:water partition coefficients. The hypothermic and motor impairment responses to ethanol were significantly reduced on day 2 in rats receiving
Harold Kalant +3 more
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Drugs, 2003
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported after therapeutic doses, but critical analysis indicates that most patients with alleged toxicity ...
Kieran F. Scott +2 more
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The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported after therapeutic doses, but critical analysis indicates that most patients with alleged toxicity ...
Kieran F. Scott +2 more
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2020
Centuries of political and religious struggle and social advances regarding the ethical-political definition of toleration will be required before civil society can achieve Thomas More's (1478-1535) utopia: namely, a society where no citizen is judged according to religion.
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Centuries of political and religious struggle and social advances regarding the ethical-political definition of toleration will be required before civil society can achieve Thomas More's (1478-1535) utopia: namely, a society where no citizen is judged according to religion.
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On Tolerance and the Limits of Toleration
Diogenes, 1996Two main but discrepant tendencies characterize the intellectual climate of our world at the turn of the century. We promote, on the one hand, “respect for human rights,” i.e. for certain universal norms, but on the other hand, equally promote “respect to all cultures,”which are differentiated among themselves by their different world-views and their ...
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The Tolerance Dose or Tolerance Intensity
Radiology, 1946Radiological Research Laboratory, Columbia University, New York City In view of the serious damage which may result from too much exposure to radiation, it becomes extremely important to determine the amount which can be tolerated without producing any undesirable effects.
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Current Opinion in Organ Transplantation, 2013
As the induction and maintenance of donor-specific tolerance is a central aim in solid organ transplantation, it is essential that clinicians are able to identify and monitor tolerance accurately and reliably. This review highlights recent advances in defining sets of biomarkers in noninvasive samples that may guide minimization and withdrawal of ...
Gökmen, Refik, Hernandez Fuentes, Maria
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As the induction and maintenance of donor-specific tolerance is a central aim in solid organ transplantation, it is essential that clinicians are able to identify and monitor tolerance accurately and reliably. This review highlights recent advances in defining sets of biomarkers in noninvasive samples that may guide minimization and withdrawal of ...
Gökmen, Refik, Hernandez Fuentes, Maria
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Cocaine tolerance and cross-tolerance.
The Journal of Pharmacology and Experimental Therapeutics, 1993Pharmacological mechanisms by which tolerance develops to the behavioral effects of cocaine were assessed by examining cross-tolerance to specific drugs. Daily experimental sessions were conducted in which rats were trained to press a key under a fixed-ratio 30-response schedule of food reinforcement (each 30th response produced food).
J L, Katz +4 more
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The American Journal of Cardiology, 1985
These studies have shown the following: Tolerance to the hemodynamic and antianginal effects of isosorbide dinitrate. Tolerance develops quickly and can be demonstrated within 24 hours. Tolerance is rapidly reversed and the return of normal responsiveness is seen within 21 hours withdrawal of isosorbide dinitrate.
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These studies have shown the following: Tolerance to the hemodynamic and antianginal effects of isosorbide dinitrate. Tolerance develops quickly and can be demonstrated within 24 hours. Tolerance is rapidly reversed and the return of normal responsiveness is seen within 21 hours withdrawal of isosorbide dinitrate.
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