Results 71 to 80 of about 1,715,473 (311)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Tolerance of Radial-Basis Functions Against Stuck-At-Faults [PDF]
, 2005 Eickhoff R, Rückert U. Tolerance of Radial-Basis Functions Against Stuck-At-Faults. In: Proceedings of the International Conference on Artificial Neural Networks (ICANN). Warsaw, Poland; 2005: 1003-1008.Neural networks are intended to be used in future
Eickhoff, Ralf, Rückert, Ulrich
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Paths to a Culture of Tolerance and Peace
, 2021 International audienceWe are living today in a multicultural world, surrounded by people from different backgrounds, cultures and religions. Establishing tolerance and peace has become crucial.
Zein, Basma El, Jarwan, Ahmed Al
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BMC Plant BiologyCRISPR/Cas technologies have revolutionized plant genome editing, yet their inherent bias toward small insertions or deletions (indels) limits their utility for dissecting regulatory elements and generating impactful allelic variants. Here, we report the
Vikas Devkar +3 more
doaj +1 more source
Evaluation of a new method for quantification of heat tolerance in different wheat cultivars
Journal of Integrative Agriculture, 2018 Heat stress seriously affects wheat production in many regions of the world. At present, heat tolerance research remains one of the least understood fields in wheat genetics and breeding and there is a lack of effective methods to quantify heat stress ...
Qiang LI +10 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Towards Immune Inspired Fault Tolerance in Embedded Systems [PDF]
, 2002 The immune system is a remarkable natural system that is proving to be of great inspiration to computer scientists and engineers alike. This paper discusses the role that the immune system can play in the development of fault tolerant embedded systems ...
Timmis, Jon +3 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
tolerance: An R Package for Estimating Tolerance Intervals [PDF]
The tolerance package for R provides a set of functions for estimating and plotting tolerance limits. This package provides a wide-range of functions for estimating discrete and continuous tolerance intervals as well as for estimating regression ...
Derek S. Young
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