Results 61 to 70 of about 10,867,351 (301)
Precision Die Design by The Die Expansion Method
The Proceedings of the Nigerian Academy of Science, 2013 A new method for the design of precision dies used in cold forging, extrusion and drawing processes is presented. It is based on die expansion. It attempts to provide a clear-cut theoretical basis for the selection of critical die dimensions for this ...
Akii O. Ibhadode FAS
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Defect and fault tolerance techniques for nano-electronics
, 2011 Nanotechnology-based devices are believed to be the future possible alternative to CMOS-based devices. It is predicted that the high integration density offered by emerging nanotechnologies will be accompanied by high manufacturing defect rates and high ...
Melouki, Aissa
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Tolerance Type Screening Method Based on Similarity Evaluation
Applied SciencesIn the context of automatic generation methods for tolerance specifications, the current approach entails designers subjectively selecting geometric tolerances suitable for annotation from the tolerance types generated through automatic reasoning.
Guanghao Liu, Meifa Huang, Zhemin Tang
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Advances in Mechanical Engineering, 2017 The auto-body is usually composed of compliant sheet metals. The assembly variation is inevitable in the process of auto-body assembly. A reasonable tolerance allocation method for compliant sheet metal body parts is an important means to control ...
Sha Xu, Yanfeng Xing, Weifeng Chen
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Optimal F-Number of Ritchey–Chrétien Telescope Based on Tolerance Analysis of Mirror Components
Applied Sciences, 2020 The Ritchey–Chrétien telescope has been the key optical module for remote sensing instruments (RSI), in which the root mean square (RMS) random surface wavefront error and the alignment error of the primary and the secondary mirror takes the highest ...
Sheng-Feng Lin +2 more
doaj +1 more source
RS method vs Iterative Tolerance Analysis method to optimal tolerance design by using CAT systems
, 2007 The paper deals with the optimal tolerance design by using CAT systems. It focuses on aspects that characterize the deliverability of assembly functional requirements to tolerance features and design.
PATALANO S, GERBINO S, LANZOTTI A
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