Results 71 to 80 of about 10,867,351 (301)
Perspective: the gist of public tender for service design [PDF]
, 2018 Governments around the world are increasingly formalising design as an innovative approach to renew public services. In this development, the capabilities of external service design consultancies often play an important part, which calls for new insights
Person, Oscar +3 more
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Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Combined Time and Information Redundancy for SEU-Tolerance in Energy-Efficient Real-Time Systems
, 2006 Recently the trade-off between energy consumption and fault-tolerance in real-time systems has been highlighted. These works have focused on dynamic voltage scaling (DVS) to reduce dynamic energy dissipation and on time redundancy to achieve transient ...
Rosinger, Paul +4 more
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
A standby-Sparing Technique with Low Energy-Overhead for Fault-Tolerant Hard Real-Time Systems [PDF]
, 2009 Time redundancy (rollback-recovery) and hardware redundancy are commonly used in real-time systems to achieve fault tolerance. From an energy consumption point of view, time redundancy is generally more preferable than hardware redundancy.
Eles, Petru +8 more
core +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
, 2002 In this work the authors deal with the problem regarding tolerance design of the journal – bearing kinematic joint, in which hydrodynamic lubrication conditions are realised.
PATALANO, STANISLAO +4 more
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Optimal design for tolerance and manufacturing allocation
, 2018 : "We introduce a methodology for concurrent design that considers the allocation of tolerances and manufacturing processes for minimum cost. Cost is approximated as a hyperbolic function over tolerance, and worst-case stack-up tolerance is assumed.
Thomas R. Kurfess (5357900) +2 more
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
A New Fuzzy Set Approach to the Tolerance Analysis and Parameter Design Problems
, 2002 Tolerance is believed to be unavoidable and necessary in engineering design and manufacturing due to universal randomness. The Tolerance Analysis and Parameter Design problems are therefore critical to quality control in the modern engineering context ...
Ding, Yi
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