Results 91 to 100 of about 16,611,336 (253)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Evaluating the Effects of Cytomegalovirus Glycoprotein B on the Maturation and Function of Monocyte-derived dendritic cells [PDF]

Journal of Advanced Biomedical Sciences, 2015
Background & Objectives: Interaction of cytomegalovirus glycoprotein B with toll-like receptors of dendritic cells leads to early signaling and innate immune responses. The aim of this study is to evaluate the effects of cytomegalovirus glycoprotein B on
Afsson shariat, Ramin Yaghobi, Talat Mokhtariazad, Mohammad Hossein Karimi, Seyed Mohamad Moazeni   +4 more
doaj   +2 more sources

Gene Expression Profiling of Toll-Like Receptor 4 and 5 in Peripheral Blood Mononuclear Cells in Rheumatic Disorders: Ankylosing Spondylitis and Rheumatoid Arthritis

Iranian Journal of Allergy, Asthma and Immunology, 2016
No Abstract###
Simin Almasi, Saeed Aslani, Hadi Poormoghim, Ahmad Reza Jamshidi, Shiva Poursani, Mehdi Mahmoudi   +5 more
doaj  

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review

Revista da Sociedade Brasileira de Medicina Tropical
Invasive aspergillosis is a common fungal infection in immunocompromised individuals. Some studies have shown that toll-like receptor and dectin-1 genetic polymorphisms may alter signaling pathways, thus increasing an individual’s susceptibility to ...
Daiane de Oliveira Cunha, Jacqueline Andréia Bernardes Leão-Cordeiro, Hellen da Silva Cintra de Paula, Fábio Silvestre Ataides, Vera Aparecida Saddi, Cesar Augusto Sam Tiago Vilanova-Costa, Antonio Márcio Teodoro Cordeiro Silva   +6 more
doaj   +1 more source

Kolaviron shows anti-proliferative effect and down regulation of vascular endothelial growth factor-C and toll like receptor-2 in Wuchereria bancrofti infected blood lymphocytes

Journal of Infection and Public Health, 2017
The anti-proliferative effect and down regulation of vascular endothelial growth factor C and toll like receptor-2 by kolaviron on Wuchereria bancrofti infected peripheral blood lymphocytes were investigated.
Aliyu Muhammad, Audu Funmilola, Idowu A. Aimola, Iliya S. Ndams, Mairo H. Inuwa, Andrew J. Nok   +5 more
doaj   +1 more source

Sustained Toll-like receptor 9 activation promotes systemic and cardiac inflammation, and aggravates diastolic heart failure in SERCA2a KO mice [PDF]

, 2015
Aim Cardiac inflammation is important in the pathogenesis of heart failure. However, the consequence of systemic inflammation on concomitant established heart failure, and in particular diastolic heart failure, is less explored.
Sigve Dhondup Holmen (812740), Ahmed, Muhammad Shakil, Aronsen, Jan Magnus, Lili Zhang, Muhammad Shakil Ahmed (812741), Leif Erik Vinge (329788), Pål Aukrust (151370), Zhang, Lili, Øystein Sandanger (329789), Håvard Attramadal (224421), Helge Scott, Håvard Attramadal, Attramadal, Håvard, Arne Yndestad (224387), Sigve Dhondup Holmen, Holmen, Sigve, Sandanger, Øystein, Ivar Sjaastad, Lars Gullestad (224437), Pål Aukrust, Christensen, Geir Arve, Ivar Sjaastad (162165), Lili Zhang (120447), Muhammad Shakil Ahmed, Geir Christensen (162197), Haugstad, Solveig Bjærum, Dhondup, Yangchen, Yangchen Dhondup, Scott, Helge, Lars Gullestad, Yndestad, Arne, Gullestad, Lars, Sjaastad, Ivar, Yangchen Dhondup (812738), Helge Scott (4898), Trine Ranheim, Arne Yndestad, Solveig Bjærum Haugstad, Katrine Alfsnes (616207), Alfsnes, Katrine, Solveig Bjærum Haugstad (812739), Trine Ranheim (151364), Geir Christensen, Jan Magnus Aronsen, Katrine Alfsnes, Leif Erik Vinge, Vinge, Leif Erik, Jan Magnus Aronsen (347485), Ranheim, Trine, Aukrust, Pål, Øystein Sandanger   +50 more
core   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Toward a porcine in vivo model to analyze the pathogenesis of TLR5-dependent enteropathies

Gut Microbes, 2020
Non-communicable diseases, such as the metabolic syndrome and inflammatory bowel disease, constitute serious public health threats in developed countries.
Robert Pieper, Niels van Best, Kira van Vorst, Friederike Ebner, Monika Reissmann, Mathias W. Hornef, Marcus Fulde   +6 more
doaj   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source